Yuki Donen,Yoko Ikoma,Ko Matsui
Yuki Donen
Neural signal processing in the cerebral cortex is often regarded as robust and stereotyped; however, the brain's internal environment undergoes dynamic fluctuations across the day. Whether these diurnal rhythms modulate cortical responsive...
Causal role of persistent neural activity in the mouse medial prefrontal cortex in promotion of wakefulness [0.03%]
持续的大脑皮层活动通过促进觉醒来维持清醒状态的机制研究
Sakiko Honjoh,Ayako Imamura,Saiko Akahira et al.
Sakiko Honjoh et al.
During wakefulness, cortical neurons fire tonically and asynchronously to constantly support ongoing cognitive functions, whereas they show synchronized cessation of firing, so called 'OFF periods', during NREM sleep. Previous studies repor...
Axonal Sprouting from Adjacent Dorsal Root Ganglia Following Cervical Dorsal Root Avulsion in mice [0.03%]
小鼠颈椎背根撕脱后相邻的脊神经节轴突芽生现象的研究
Gaku Kanemoto,Takahide Itokazu,Toru Nakanishi et al.
Gaku Kanemoto et al.
Brachial plexus injury is a neurological injury caused by trauma, and effective treatments remain limited. Understanding its pathology is necessary to develop new therapeutic strategies. In this study, we used a dorsal root avulsion mouse m...
Tomomi Takahashi,Takashi Nonaka,Reiko Ohtani et al.
Tomomi Takahashi et al.
Tau protein, a central player in Alzheimer's disease (AD), exhibits cytotoxicity upon fibril formation. Understanding the early stages of tau fibrillization is therefore critical for the development of effective thera- peutics. Previous work [Ras...
Modeling natural neural networks of decision making with artificial neural networks [0.03%]
用人工神经网络模拟决策的自然神经网络
Akihiro Funamizu,Ryo Karakida
Akihiro Funamizu
One main focus in neuroscience is to understand the relationship between decision making and various brain regions. Researchers use machine learning approaches to model the neural circuits of cerebral cortices, cerebellum, and basal ganglia...
A decade progress in the phenotyping of AppNL-G-F knock-in mouse model of Alzheimer's disease [0.03%]
APPNL-G-F敲入小鼠模型阿尔茨海默病表型研究十年进展
Tatsuya Manabe,Takashi Saito
Tatsuya Manabe
Numerous mouse models of Alzheimer's disease (AD) have developed since the discovery of mutations causing familial AD. These models successfully recapitulate the progressive amyloid pathology over time, thus serving as indispensable tools f...
Masami Masuda-Suzukake,Shotaro Shimonaka,Takashi Nonaka et al.
Masami Masuda-Suzukake et al.
Alzheimer's disease (AD) is characterized by extracellular amyloid plaques composed of amyloid-β and intracellular neurofibrillary tangles composed of aggregated tau protein. In sporadic AD, the distribution of pathological tau progresses ...
Abnormalities in the functional activity of neural networks in a human iPSC model of Dravet syndrome [0.03%]
基于人类iPSC的Dravet综合征神经网络模型的功能异常研究
Ropafadzo Mzezewa,Tanja Hyvärinen,Oskari Kulta et al.
Ropafadzo Mzezewa et al.
Dravet syndrome (DS) is a severe pediatric epilepsy primarily caused by de novo mutation in the SCN1A gene encoding the alpha subunit of the voltage-gated sodium channel. While early in vivo studies linked DS pathology to GABAergic disinhib...
Neurotransmitter receptor gene expression patterns associated with reward-related neural representations [0.03%]
与奖赏相关神经表征有关的神经递质受体基因表达模式
Kaosu Matsumori,Kana Matsuyanagi,Kenji Matsumoto
Kaosu Matsumori
The neural representation of reward is underpinned by neurotransmitter systems; however, current human neuroimaging techniques cannot assess the receptor-specific contributions to reward processing. We investigated the relationships between...
The modified spatial context memory test for assessing cognitive aging in middle-aged and older adults [0.03%]
适用于中老年人认知老化的空间情境记忆测验修改版
Hsuan-Min Wang,Yo-Ping Huang,Hsun-Yu Kuo et al.
Hsuan-Min Wang et al.
Deficits in spatial-context memory may be risk factors for Alzheimer disease (AD). This study aimed to investigate spatial-context memory and spatial navigation in middle-aged and older adults using a modified spatial-context memory test (S...