Profiling of RUVBL2-Induced Transcriptome Alterations Highlights a Critical Role for Chromatin Remodeling in Ovarian Cancer [0.03%]
RUVBL2诱导的转录组变化谱型揭示了染色质重塑在卵巢癌中的关键作用
Renhao Xue,Yingjie Wang,Xiaomei Luo et al.
Renhao Xue et al.
Cancerous transcriptome alterations in carcinoma cells could be originated from either genetic copy number changes or epigenetic reprogramming. Ovarian cancer (OV) is the most malignant gynecologic tumor, known for high aneuploidy with robu...
Effect of High Hydrostatic Pressure (HHP) on the Enzymatic Hydrolysis of Fish Gelatin [0.03%]
高压对鱼明胶酶解的影响
Ilhami Okur,Mecit Halil Oztop,Hami Alpas
Ilhami Okur
Fish gelatin offers an alternative source for gelatin production; however, it possesses weaker functional properties, such as a low melting temperature and gel strength. Protein hydrolysates, produced through the hydrolysis of food proteins...
Curcumin Induces Transgenerational and Sex-Specific Effects on Lifespan, Gene Expression, and Metabolism in the Fruit Fly Drosophila melanogaster [0.03%]
姜黄素诱导果蝇Drosophila melanogaster的跨世代和性别特异性的寿命、基因表达及代谢效应
Silvana Hof-Michel,Belén Olga Ferrando Hernandez,Andreas Vilcinskas et al.
Silvana Hof-Michel et al.
Curcumin is a bioactive compound found in turmeric (Curcuma longa) and is widely recognized for its health-promoting effects, including anti-inflammatory, antioxidant, and anti-carcinogenic properties. It can also mediate epigenetic effects...
Gut Microbial Metabolite Crosstalk in Crohn's Disease: Network Pharmacology Unveils Dual-Axis Pathogenesis and Therapeutic Targets [0.03%]
网络药理学揭示克罗恩病肠道微生物代谢物交叉对话的双轴发病机制和治疗靶点
Shiting Chen,Yang Li,Jiaxin Liu et al.
Shiting Chen et al.
Crohn's disease (CD), a chronic inflammatory bowel disorder, is driven by dysregulated interactions between gut microbiota and host metabolism. Here, we developed a computational framework integrating multiomics profiling, network pharmacol...
Targeting Cellular Energetics via Ferroptosis Mediated Cell Death in Resistant Colorectal Cancer Stem Cells [0.03%]
靶向细胞能量代谢介导的耐药性结直肠癌干细胞铁死亡清除疗法研究进展
Tanika Biswas,Sumit Mallick,Utsav Sen et al.
Tanika Biswas et al.
Ferroptosis, a newly discovered non-apoptotic form of cell death triggered by iron-dependent toxic membrane lipid peroxidation, establishes a link between redox biology, metabolism, and human health. By inducing ferroptosis, it is possible ...
Giovanna De Simone,Alessandra di Masi,Grazia R Tundo et al.
Giovanna De Simone et al.
Nitrosative stress plays a key role in the etiology of several human diseases, such as atherosclerosis, inflammation, cancer, and neurological diseases. Peroxynitrite is one of the most potent biological nitrosative agents, being produced a...
Fucosterol Promotes Browning in Mouse 3T3-L1 Adipocytes Through HO-1/Nrf2 and AMPK Pathways [0.03%]
茯苓sterol通过HO-1/Nrf2和AMPK途径促进小鼠3T3-L1脂肪细胞棕色化
Indyaswan T Suryaningtyas,Won-Kyo Jung,Jae-Young Je
Indyaswan T Suryaningtyas
Browning of white adipose tissue offers a promising strategy to manage obesity by enhancing thermogenesis and lipid oxidation. Although fucosterol, a phytosterol found in brown seaweeds, has been recognized for its antioxidant and metabolic...
Long-Term Intake of Oleic Acid-Rich Palm Oil Induces Obesity Without Impairing Hypothalamic Insulin Sensitivity and Redox Activity in Male Wistar Rats [0.03%]
富含油酸的棕榈油长期摄入可诱导大鼠肥胖而不影响其下丘脑胰岛素敏感性和氧化还原活性
Aleksandra Ruzicic,Tamara Dakic,Tijana Srdic et al.
Aleksandra Ruzicic et al.
The debate over the impact of extensive palm oil consumption on human health, driven by its economic affordability, persists due to its high saturated fat content and potential health risks. Conversely, its diverse bioactive compounds offer...