ASNS Regulates H2O2-Induced Senescence, Oxidative Stress, and Glucose Metabolism in ARPE-19 Cells by Modulating USP13 Expression [0.03%]
ASNS通过调节USP13表达调控H2O2诱导的衰老、氧化应激和糖代谢在ARPE-19细胞中的作用
Xiangyang Xin,Xin Zhao,Xiaobo Han et al.
Xiangyang Xin et al.
Age-related macular degeneration (AMD) is a common degenerative disease of the eye that ultimately leads to irreversible vision loss. Asparagine synthase (ASNS) is an aminotransferase, and its low expression is associated with retinal damag...
Andrographolide Promotes Ferroptosis in Pancreatic Cancer via Targeting and Activating HSP90/GPX4 Ubiquitination [0.03%]
安格斯亭醇通过靶向和激活HSP90/GPX4泛素化促进胰腺癌铁死亡
Asmat Ullah,Hongyan Xing,Xinxin Wang et al.
Asmat Ullah et al.
Pancreatic adenocarcinoma accounts for 90% of pancreatic cancer cases, the deadliest kind. PC patients' poor immunotherapy, chemotherapy, and other responses lead to a generally failed treatment strategy. Thus, understanding molecular proce...
Oleuropein Aglycone Modulates Oxidative Stress and Autophagy-Related Pathways in Human Skeletal Muscle Cells [0.03%]
羟基苦参碱调节氧化应激和自噬相关通路在人类骨骼肌细胞中的作用
Giulia Polacchini,Andrea Venerando,Anne Bigot et al.
Giulia Polacchini et al.
A gradual loss of muscle mass and strength increases the risk of falls, frailty and mortality. It is the result of a combination of intrinsic factors such as oxidative stress, mitochondrial dysfunction and extrinsic factors such as poor nut...
Trihydroxylated Anthocyanins Potentiate Effects of Docetaxel in Mesenchymal Triple Negative Breast Cancer Cells [0.03%]
三羟基化花青素增强三阴性乳腺癌间充质细胞的多西他赛效应
Mafalda Ribeiro,Miguel A Faria,Martin Vojtek et al.
Mafalda Ribeiro et al.
Triple negative breast cancer (TNBC) presents a significant therapeutic challenge due to its poor prognosis and limited treatment options. While anthocyanins, a group of flavonoids, exhibit promising anticancer potential, their structure-ac...
Fingernail Mineral Profiling as a Non-Invasive Tool to Assess Dietary and Lifestyle Factors: Results From the Cross-Sectional Fulda NutriNAIL Study [0.03%]
fingernail微量元素分析评估饮食和生活方式因素的无创工具：德国Fulda NutriNAIL横断面研究的结果
Nina Sonntag,Lina Müller,Katja Plendl et al.
Nina Sonntag et al.
In the past, fingernail and toenail analyses were mainly used for toxicological investigations on heavy metals and only a few studies used mineral content as a biomarker for assessing lifestyle or dietary habits. The Fulda NutriNAIL study e...
A Comprehensive Insight Into the Roles of Exosomal circRNAs in Metabolic Syndrome [0.03%]
外泌体环状circRNAs在代谢综合征中作用的研究进展
Azadeh Taherpour,Safieh Ebrahimi,Farshad Mirzavi
Azadeh Taherpour
Exosomes are nano-sized extracellular vesicles that contain specific proteins, nucleic acids, and lipids. These small vesicles are significant in a wide range of physiological and pathological conditions. Circular RNAs (circRNAs) are a subc...
The Function and Supramolecular Assembly of the Mitochondrial Respiratory Complexes Underlie Hypertension-Related Stroke Susceptibility in a Model of Complex Human Disease [0.03%]
线粒体呼吸链超级复合物的函数及其超分子聚合与复杂人类疾病模型中高血压相关性卒中的易感性有关
Antonia Cugliari,Cristina Algieri,Patrycja Anna Glogowski et al.
Antonia Cugliari et al.
The role of mitochondrial dysfunction underlying increased susceptibility to cerebrovascular disease in hypertension, previously detected in stroke-prone spontaneously hypertensive rats (SHR-SP) fed with a high-salt stroke-permissive Japane...
Bromelain Alleviates 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats Through the Interplay of SIRT1/PGC-1α and FOXO3a Pathways [0.03%]
菠萝蛋白酶通过SIRT1/PGC-1α和FOXO3a途径的相互作用缓解3-硝基丙酸诱导的大鼠亨廷顿病样症状
Omnia M Nady,Salma E Said,Sherehan M Ibrahim et al.
Omnia M Nady et al.
Bromelain, a combination of pineapple-derived enzymes, has demonstrated neuroprotective effects owing to its antioxidant and anti-inflammatory attributes. The current study intended to explore bromelain's neuroprotective impact against 3-ni...
TGFβ Participation in the Remyelination Process Through Microglial Modulation and Oligodendrocyte Maturation [0.03%]
转化生长因子通过调节小胶质细胞和少突胶质细胞成熟参与脱髓鞘疾病的修复过程
Laura Ivonne Gómez Pinto,Ana María Adamo,Patricia Andrea Mathieu
Laura Ivonne Gómez Pinto
Central nervous system (CNS) diseases occur in the context of inflammation and demyelination. Demyelination is a pathological process in which myelin sheaths are lost from around axons, while remyelination is the restoration of myelin sheat...
Piperlongumine Triggers Reactive Oxygen Species Driven Mitochondrial Dysfunction Leading to Apoptosis in Human Colon Cancer Cells [0.03%]
毕澄果素通过诱导活性氧介导的线粒体功能异常促进人类结肠癌细胞凋亡
Rajeev Kumar Sahoo,Surya Kant Tripathi,Krishnendu Barik et al.
Rajeev Kumar Sahoo et al.
Prolonged use of conventional chemotherapy has led to adverse side effects and drug resistance, leading to therapeutic failure in colon cancer patients. An alternative therapy involving natural products with least toxicity can show promisin...