Involvement of metformin and aging in salivary expression of ACE2 and TMPRSS2 [0.03%]
二甲双胍和年龄在唾液中ACE2和TMPRSS2表达的关联研究
Yosuke Shikama,Kunihiro Otsuka,Yuka Shikama et al.
Yosuke Shikama et al.
SARS-CoV-2-related proteins, ACE2 and TMPRSS2, are determinants of SARS-CoV-2 infection. Although these proteins are expressed in oral-related tissues, their expression patterns and modulatory mechanisms in the salivary glands remain unknow...
Harnessing the ubiquitin proteasome system as a key player in stem cell biology [0.03%]
利用泛素-蛋白酶体系统在干细胞生物学中的核心作用
Hind Atta,Dina H Kassem,Mohamed M Kamal et al.
Hind Atta et al.
Intracellular proteins take part in almost every body function; thus, protein homeostasis is of utmost importance. The ubiquitin proteasome system (UPS) has a fundamental role in protein homeostasis. Its main role is to selectively eradicat...
Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway [0.03%]
姜黄素通过调节鞘氨醇激酶1/核因子кB信号通路缓解溃疡性结肠炎
Xiuli Zhang,Hao Zhang,Jingting Wang et al.
Xiuli Zhang et al.
Curcumin, a compound from Curcuma longa L., has significant anti-inflammatory properties. However, the mechanisms underlying its anti-inflammatory activity in dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) remain inadequately ...
Clock system disruption in male Fischer 344 rats fed cafeteria diet and administered sweet treats at different times: The zeitgeber role of grape seed flavanols [0.03%]
给予不同时间的高糖西式饮食和甜食干预对雄性Fischer 344大鼠时钟系统扰乱及葡萄籽原花青素调节作用的研究
Jorge R Soliz-Rueda,Raúl López-Fernández-Sobrino,Harriët Schellekens et al.
Jorge R Soliz-Rueda et al.
Current lifestyles include calorie-dense diets and late-night food intake, which can lead to circadian misalignment. Our group recently demonstrated that sweet treats before bedtime alter the clock system in healthy rats, increasing metabol...
Exploring vimentin's role in breast cancer via PICK1 alternative polyadenylation and the miR-615-3p-PICK1 interaction [0.03%]
通过PICK1的多聚腺苷化和miR-615-3P-PICK1的相互作用探讨波形蛋白在乳腺癌中的作用
Xinyan Jia,Lujing Shao,Hong Quan et al.
Xinyan Jia et al.
Breast cancer continues to be a major health issue for women worldwide, with vimentin (VIM) identified as a crucial factor in its progression due to its role in cell migration and the epithelial-to-mesenchymal transition (EMT). This study f...
FAM49B drives colorectal cancer progression by stabilizing c-Myc through NEK9 phosphorylation [0.03%]
FAM49B通过NEK9磷酸化稳定c-Myc驱动结直肠癌进展
Chen Lu,Tianyu Liu,E Yimin et al.
Chen Lu et al.
Colorectal cancer (CRC) ranks as the third most prevalent cancer globally and is the second leading cause of cancer mortality. FAM49B, a member of the FAM49 gene family, is a recently identified, evolutionarily conserved gene. Emerging stud...
Long non-coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR-4673/TPX2 axis and activating Wnt/β-catenin signaling pathway [0.03%]
长非编码RNA LINC01224通过miR-4673 / TPX2轴和激活Wnt / β-catenin信号通路在子宫内膜癌中起致癌作用
Shuqing Lv,Xinlu Zhang,Fangfang Lang et al.
Shuqing Lv et al.
Endometrial cancer (EC) is a prevalent gynecological malignancy with a rising incidence and poor prognosis in advanced cases. Long non-coding RNAs (lncRNAs) have been implicated in various cancers, including EC. This study explores the role...
Echinacoside promotes collagen synthesis and survival via activation of IGF-1 signaling to alleviate UVB-induced dermal fibroblast photoaging [0.03%]
刺五加皂诱导IGF-1信号转导促进胶原蛋白合成和细胞存活从而缓解UVB照射引起的成纤维细胞光老化损伤
Su-Ying Wen,Shang-Chuan Ng,Lloyd Noriega et al.
Su-Ying Wen et al.
Ultraviolet (UV) irradiation is a major factor contributing to skin photoaging, including the formation of reactive oxygen species (ROS), collagen breakdown, and overall skin damage. Insulin-like growth factor-I (IGF-1) is a polypeptide hor...
Comprehensive analysis of the value of angiogenesis and stemness-related genes in the prognosis and immunotherapy of ovarian cancer [0.03%]
血管生成和干细胞相关基因在卵巢癌预后和免疫治疗中的价值的全面分析
Linsen Zhou,Yu Min,Qiqi Cao et al.
Linsen Zhou et al.
Tumor angiogenesis and the presence of cancer stem cells (CSCs) are critical characteristics of tumors. Previous research has demonstrated that cancer stem cells promote tumor angiogenesis, while increased vascularity, in turn, fosters the ...
Cristina Mesas,Javier Moreno,Kevin Doello et al.
Cristina Mesas et al.
Stem cells play a critical role in human tissue regeneration and repair. In addition, cancer stem cells (CSCs), subpopulations of cancer cells sharing similar characteristics as normal stem cells, are responsible for tumor metastasis and re...