taVNS Alleviates Preeclampsia-Induced Placental Trophoblast Dysfunction by Attenuating Endoplasmic Reticulum Ca2+ Dysregulation via ACh-M3AChR-PERK/IP3R1 Signaling [0.03%]
电针通过胆碱能M3受体和内质网Ca²⁺传感器IP3R1及PERK通道缓解子痫前期诱发的胎盘滋养细胞功能障碍
Chengcheng Mu,Shouzhu Xu,Dongdong Wu et al.
Chengcheng Mu et al.
Preeclampsia (PE) is a major cause of maternal and perinatal morbidity, driven by placental dysfunction, oxidative stress, and trophoblast apoptosis. This study investigates the therapeutic potential of transcutaneous auricular vagus nerve ...
Regulation of the rainbow trout spleen corticotropin-releasing factor system in response to inflammatory challenges: roles of NF-κB and cortisol [0.03%]
NF-κB和皮质醇在调节虹彩 trout 脾脏促肾上腺皮质激素释放因子系统中的作用：对炎症刺激的响应
Brett M Culbert,Leah Grosman,Tania Rodríguez-Ramos et al.
Brett M Culbert et al.
The corticotropin-releasing factor (CRF) system bidirectionally interacts with cytokines and other immune-related components in mammals. However, the nature of these interactions remains poorly characterized in other vertebrates, including ...
Bergamot (Citrus bergamia) preserves cardiac structure and function and modulates myocardial redox and metabolic profiles in diet-induced obesity [0.03%]
芸香柑橘(Citrus bergamia)可保持心脏结构和功能并调节饮食诱导型肥胖所导致的心肌氧化还原及代谢状况
Matheus Antonio Filiol Belin,Jordanna Cruzeiro,Aline Nunes et al.
Matheus Antonio Filiol Belin et al.
Obesity promotes cardiac remodeling and dysfunction through oxidative stress, inflammation, and metabolic disturbances. Citrus bergamia (bergamot) has shown beneficial effects on obesity-related cardiometabolic risk factors, but its cardiac...
Fatty Acids and Breast Cancer: Epidemiology, Subtype-Specific Metabolism, Immune Regulation, and Clinical Translation [0.03%]
脂肪酸与乳腺癌：流行病学、亚型特异性代谢、免疫调节和临床转化
Camila Farias,Giulio Martinelli,Benjamín Walbaum et al.
Camila Farias et al.
Fatty acids (FAs) are bioactive dietary and metabolic molecules that participate in membrane architecture, energy homeostasis, inflammatory signaling, gene regulation and immune function, all of which intersect with breast cancer (BC) risk,...
Hepatic Neu1 Deficiency Drives Metabolic Dysregulation via GCGR Desialylation-dependent cAMP-PKA Signaling and Inflammatory Response in Old Mice [0.03%]
老年小鼠肝脏Neu1缺陷通过去岩藻糖基化GCGR依赖的cAMP-PKA信号和炎症反应驱动代谢紊乱
Shiran Mei,Huiqin Hu,Guoxue Zhu et al.
Shiran Mei et al.
Background: Neuraminidase 1 (Neu1) plays a crucial role in the removal of sialic acid from glycoproteins and glycolipids, significantly influencing hepatic glycolipid metabolism. However, its precise contributions to live...
IP3R drives cardiomyocyte injury by enhancing MAM-mediated Ca2+ transfer and mitochondrial dysfunction [0.03%]
IP3R通过增强MAM介导的Ca2+转移和线粒体功能障碍驱动心肌细胞损伤
Haihui Yang,Jinming Zhu,Guifang Li et al.
Haihui Yang et al.
Background: Heart failure (HF) is the terminal stage of various cardiovascular diseases. Mitochondrial Ca2+ overload and dysfunction mediated by mitochondria-associated ER membranes (MAMs) are recognized contributors to H...
Gut microbiome associations in male reproductive endocrine-skeletal physiology: a taxonomic-resolution Mendelian randomization study [0.03%]
基于孟德尔随机化的_taxonomy分辨率_男性生殖内分泌骨骼生理学的肠道微生物组相关性研究
Giap Duc Ha,Ying Li,Qi Liu et al.
Giap Duc Ha et al.
The gut microbiome is increasingly linked to endocrine physiology, but human evidence that individual microbial traits contribute to male reproductive and skeletal phenotypes remains largely observational. We integrated MiBioGen genus-level...
Identification of key biomarkers for ferroptosis in diabetic kidney disease using machine learning and WGCNA [0.03%]
基于机器学习和WGCNA的糖尿病肾病铁死亡关键生物标志物识别
Yuxi Liu,Yunfei Huang,Yanyu Su et al.
Yuxi Liu et al.
Objective: Early detection of diabetic kidney disease (DKD) remains challenging because currently available clinical markers mainly reflect established renal injury rather than early pathogenic changes. Ferroptosis has be...
Small molecule ligands for the melanocortin-4 receptor: pharmacology, biased signaling, and pharmacoperone potential [0.03%]
黑色素皮质激素受体4的小分子配体：药理学、偏向信号转导和药物伴侣潜能
Ya-Xiong Tao,Ren-Lei Ji
Ya-Xiong Tao
The melanocortin-4 receptor (MC4R) is a critical regulator of energy homeostasis, affecting both energy intake and expenditure. It is also involved in regulating reproduction. Recent clinical success with peptide agonists has validated MC4R...
Trim67 alleviates lipotoxicity-induced β-cell dysfunction by modulating Sirt1-mediated mitochondrial function [0.03%]
_trim67通过调节Sirt1介导的线粒体功能缓解脂毒性诱导的β细胞功能障碍
Liting Wu,Qin Xiong,Fang Zou et al.
Liting Wu et al.
Background: β-cell dysfunction is a key factor in the progression of diabetes. It was reported that lipotoxicity impaired β-cell mitochondrial function. However, the molecular mechanisms regulating lipotoxicity-induced ...