Rapid in vivo loss of non-T-cell binding capacities of ATLG Grafalon® and ATG Thymoglobulin® explains selective effect on T-cell reconstitution after hematopoietic stem cell transplantation [0.03%]
ATLG Grafalon®和ATG Thymoglobulin®在体内的快速失活解释了其对造血干细胞移植后T细胞重建的特异性效应
Lisa V E Oostenbrink,Anja M Jansen-Hoogendijk,Monique M van Ostaijen-Ten Dam et al.
Lisa V E Oostenbrink et al.
Anti-thymocyte globulin (ATG Thymoglobulin®) and anti-T-lymphocyte globulin (ATLG Grafalon®) are commonly used in hematopoietic stem cell transplantation (HSCT) for in vivo T-cell depletion, aiming to reduce graft failure and graft-versus...
Dendrimer-based therapeutics in neurological disorders: Innovations and clinical prospects [0.03%]
基于树状分子的神经系统疾病治疗学：创新及临床前景
Karthikeya Lalitha Siddhartha Pallem,Anjali Jain,Anurag Aswal et al.
Karthikeya Lalitha Siddhartha Pallem et al.
The incidence of brain tumors and other neurodegenerative diseases has been increasing, whereas the treatment opportunities are limited. Brain delivery of the therapeutics has been restricted because of the presence of blood-brain barrier (...
Corrigendum to N-glycosylation of CD4+ T cell changes with the development in Graves' disease and is sensitive to methimazole treatment [Biochimica et Biophysica Acta General Subjects 1869 (2025) 130824] [0.03%]
甲状腺功能亢进症患者CD4+T细胞N-糖基化随病程改变并可被他巴唑治疗改善的修正意见（Biochim Biophys Acta General Subjects，2025(1869)：130824）
Sara Trzos,Marta Szewczyk,Paweł Link-Lenczowski et al.
Sara Trzos et al.
Targeting the IGF1/Twist1 axis: A novel mechanism for β-elemene-induced anoikis and EMT inhibition in breast cancer cells [0.03%]
targeting IGF1/Twist1轴：β-苍术素诱导的乳腺癌细胞anoikis和EMT抑制的新机制
Haibin Yan,Xinyuan Wang,Yifei Mo et al.
Haibin Yan et al.
Background: Anoikis resistance and epithelial-mesenchymal transformation (EMT) promote breast cancer spread. There is a positive correlation between twist family BHLH transcription factor 1 (Twist1) and anoikis resistance...
Trimethylamine N-oxide participates in human diseases by causing endoplasmic reticulum stress [0.03%]
三甲胺N-氧化物通过引起内质网应激参与人类疾病
Kritika Kumari,Anuja Arora,Nalini Natarajan et al.
Kritika Kumari et al.
The gut metabolite trimethylamine N-oxide (TMAO) is found to be elevated at high levels not only in the serum but also in the cerebrospinal fluid of humans. Elevated TMAO levels are associated with several human diseases, including cardiova...
Exploring the role of CCT7 in prognosis, cell cycle regulation, and immune microenvironment remodeling of lung adenocarcinoma based on multi-omics datasets and functional experiments [0.03%]
基于多组学数据集和功能实验探索CCT7在肺癌预后、细胞周期调控及免疫微环境重塑中的作用
Lie Deng,JinHui Ruan,YunYan Li
Lie Deng
Background: Lung adenocarcinoma (LUAD) represents one of the most prevalent and lethal malignancies, accounting for a significant proportion of cancer-associated deaths worldwide. The persistently unfavorable clinical out...
β-Sitosterol extends lifespan and healthspan in Caenorhabditis elegans via multi-omics analysis of longevity, neuronal, and immune pathways [0.03%]
基于多组学分析的植物甾醇β-谷甾醇延长线虫寿命并改善其健康状况研究
Thirumugam Gowripriya,Annadurai Hariharan,Radhakrishnan Yashwanth et al.
Thirumugam Gowripriya et al.
β-Sitosterol, a naturally occurring plant sterol, has attracted significant interest due to its potential health benefits. This study investigates the molecular mechanisms through which β-sitosterol influences lifespan and healthspan in C...
Spermidine deficiency induces BNIP3/LC3B-mediated mitophagy in the salivary glands of accelerated aging mice [0.03%]
精胺缺乏通过BNIP3/LC3B介导的线粒体自噬诱导加速衰老小鼠唾液腺功能减退
Nguyen Khanh Toan,Manh Dat Duong,Nguyen Duy Phu et al.
Nguyen Khanh Toan et al.
Aging is associated with mitochondrial dysfunction and altered autophagic processes, particularly in secretory organs such as the salivary glands. In this study, we investigated metabolic changes and their interactions with mitophagy in pri...
Non-equilibrium thermodynamics of cancer: Entropy dynamics and metastatic growth [0.03%]
癌症非平衡热力学：熵动力学和转移性增长
Krzysztof W Fornalski
Krzysztof W Fornalski
Cancer is a complex dissipative system operating far from equilibrium, characterized by increased entropy production compared to normal tissues. Traditional thermodynamic approaches often fail to capture its full dynamics. In this study, we...
NPR3 promotes colorectal cancer cell proliferation, migration, invasion, and chemotherapy resistance [0.03%]
NPR3促进结直肠癌细胞增殖、迁移、侵袭和化疗耐药性
Wensheng Chen,Qingshui Wang,Shuyuan Li
Wensheng Chen
Background: Lymph node metastasis is a critical prognostic factor in colorectal cancer (CRC). Identifying key genes associated with metastasis can improve risk stratification and treatment strategies. This study aimed to ...