Interleukin-27 promotes oral squamous cell carcinoma pathogenesis via FSIP1-mediated activation of the PI3K-Akt signaling pathway [0.03%]
白细胞介素-27通过FSIP1介导的PI3K-Akt信号转导途径促进口腔鳞状细胞癌的发生发展
Qing-Mei Wang,Xue-Ying Wang,Fei Lin et al.
Qing-Mei Wang et al.
Objective: This study aimed to examine the mechanisms by which Interleukin-27 (IL-27) contributes to the pathogenesis of oral squamous cell carcinoma (OSCC) through focal adhesion-induced stemness protein 1 (FSIP1)-mediat...
Transcription factor FOSL2 enhances glycolytic metabolism and metastatic progression in lung adenocarcinoma via activation of BZW1 [0.03%]
转录因子FOSL2通过激活BZW1增强肺腺癌的糖酵解代谢和转移进展
Jiayan Fang,Yufeng Yang,Hongmin Cao et al.
Jiayan Fang et al.
As a pivotal mode of energy metabolism, glycolysis has been extensively validated for its role in facilitating diverse malignant phenotypes, most notably tumor proliferation and metastatic dissemination. This study aimed at exploring the ro...
Fluorescent protein probe detects parallel hetero G-quadruplex induced by G-rich ASO for gene silencing [0.03%]
一种由G-富集的ASO诱导的用于基因沉默的平行异质G-四链体的荧光蛋白探针检测方法
Thao Thu Thi Nguyen,Dung Thanh Dang
Thao Thu Thi Nguyen
Hetero G-quadruplex assembly by RNA and G-rich antisense oligonucleotide (G-ASO) has recently emerged as a potential approach for regulating gene expression. In investigating the assembly of a hetero G-quadruplex-inducing G-ASO1, we propose...
ST3GAL3-mediated selective α2,3-sialylation of LDLR promotes vesicular stomatitis virus entry [0.03%]
ST3GAL3介导的LDLR选择性α2,3-岩藻糖基化促进狂犬病毒样病毒入侵
Tomoya Isaji,Feng Qi,Yu-Chun Chien et al.
Tomoya Isaji et al.
Background: Vesicular stomatitis virus (VSV) is a model rhabdovirus whose infectivity is determined primarily by its envelope glycoprotein (VSV-G). The low-density lipoprotein receptor (LDLR), a cell-surface glycoprotein,...
Chronic hypoxia induces skeletal muscle atrophy in mice: Potential roles of antioxidant imbalance and FOXO1 [0.03%]
慢性缺氧可诱导小鼠骨骼肌萎缩：抗氧化不平衡和FOXO1的潜在作用
Xiangyun Luo,Si Tang,Xingdan Luo et al.
Xiangyun Luo et al.
Skeletal muscle atrophy, characterized by progressive loss of muscle mass and strength, severely impairs quality of life. Chronic hypoxia is a well-recognized inducer of this condition, but its potential pathophysiological mechanisms remain...
Protective effects of dihydroartemisinin against sterile inflammation and oxidative stress in alveolar macrophages [0.03%]
双氢青蒿素对抗肺泡巨噬细胞中无菌炎症和氧化应激的保护作用
Jia-Yu Lin,Jia-Hong Chen,Cheng-Fang Tsai et al.
Jia-Yu Lin et al.
Background: Pulmonary alveoli are highly vulnerable to oxidative stress due to high oxygen tension, with alveolar macrophages serving as the primary defense. Dihydroartemisinin (dha), an active derivative of Artemisia ann...
Impact of Golgi dynamics and Golgi morphology on the regulation of glycosylation [0.03%]
高尔基体动力学和结构对糖基化调控的影响
Paul A Gleeson
Paul A Gleeson
The Golgi apparatus is a highly dynamic organelle and central to the regulation of protein glycosylation, cargo sorting and additional cellular processes such as mitosis, stress responses, autophagy and inflammation. There have been major a...
Cardiac extracellular vesicles aggravate cardiomyocyte ferroptosis in myocardial ischemia-reperfusion injury via miR-155-5p-Nfe2l2 signaling [0.03%]
心肌缺血再灌注损伤中心脏来源的细胞外囊泡通过miR-155-5p-Nfe2l2信号加重心肌细胞铁死亡
Xinyu Ge,Qingshu Meng,Jing Liu et al.
Xinyu Ge et al.
Background: Ischemia-reperfusion (IR) injury represents a major cause of cell death post myocardial infarction. Ferroptosis is a newly discovered form of regulated cell death (RCD) dependent on iron and reactive oxygen sp...
Notch1 gene promoter methylation promotes phenotypic transformation and functional alteration of VSMCs to regulate acute type A aortic dissection [0.03%]
NOTCH1基因启动子甲基化促进血管平滑肌细胞表型转化及功能改变介导急性A型主动脉夹层发生发展
Hui Liu,Zhaoshun Yuan,Zhiyuan Zhang et al.
Hui Liu et al.
Acute type A aortic dissection (ATAAD) is a life-threatening cardiovascular emergency. A key driver of disease progression is dysfunction of vascular smooth muscle cells (VSMCs), whose loss of contractile phenotype and increased matrix degr...
Phytochemistry and pharmacology of Melaleuca alternifolia: Bridging aboriginal heritage with contemporary science [0.03%]
茶树（Melaleuca alternifolia）的植物化学与药理：连接原住民遗产与现代科学
Nader Ebrahimi,Hadiseh Shokouhi,Marzieh Omrani et al.
Nader Ebrahimi et al.
Melaleuca alternifolia (Australian tea tree) sits at a rare intersection of ethnomedicine and modern pharmacology. Rooted in Bundjalung Aboriginal practice for respiratory, dermatologic, and wound care, its essential oil (TTO) has since bee...