Nasal organoids as optimal models for studying structure and function of primary nasal epithelial cell cultures [0.03%]
鼻腔类器官作为研究原代鼻上皮细胞培养结构和功能的理想模型
Mahnaz Ramezanpour,George Bouras,Sholeh Feizi et al.
Mahnaz Ramezanpour et al.
Background: Primary cell cultures serve as representative model systems for studying the normal physiology and biochemistry of cells. However, various methods exist for culturing these cells, and it remains unclear how th...
Carbohydrate sulfotransferases in humans: Repertoire and regulation of glycan-lectin interactions [0.03%]
人类碳水化合物硫酸转移酶：糖链-凝集素相互作用的谱系及调控
Kim Wai Parn,Takashi Angata
Kim Wai Parn
Background: Sulfate in glycans often serves as a determinant of glycan-protein interactions underlying mammalian physiology. Sulfated glycoconjugates in mammals encompass proteoglycans, glycoproteins, and glycolipids, and...
Sascha N Woolcott,Isabelle Da Barp,Chantelle J Capicciotti et al.
Sascha N Woolcott et al.
Glycans that terminate in monosaccharides belonging to the sialic acid family of sugars regulate myriad biological processes and are increasingly being recognized as important immunoregulatory targets. These sialoglycans are biosynthesized ...
Core fucose: Molecular targets and functions in inflammatory signaling pathways [0.03%]
岩藻糖的核心作用：炎症信号通路中的分子靶点与功能研究
Yuki Ohkawa,Junpei Abe,Taiki Kuribara et al.
Yuki Ohkawa et al.
Glycosylation is a critical post-translational modification of proteins. The proper function and expression of cell-surface proteins-including receptors, transporters, and cell adhesion molecules-depends on glycosylation. Among the various ...
Exploring the role of sialidases in Galectin-1-associated resistance to cancer therapies [0.03%]
唾液酸酶在半乳糖凝集素-1相关抗癌治疗抵抗中的作用研究
Marco A Scheidegger,Joaquín P Merlo,Santiago N Villarreal et al.
Marco A Scheidegger et al.
The diverse repertoire of cell surface glycans, generated by the coordinated activity of glycosyltransferases and glycosidases, encodes critical biological information that is interpreted by glycan-binding proteins including galectins. Gale...
Unveiling the vitro toxic impact of nanosized copper on PC12 cells: A Ferroptosis-driven mechanism [0.03%]
纳米铜对PC12细胞体外毒性的揭秘：一种铁死亡驱动机制
Zezhou Zhang,Tao Li,Jing Gao et al.
Zezhou Zhang et al.
Latest findings indicate that minute copper particles, specifically nano-Cu with a diameter falling between 15 and 30 nm, may well be capable of triggering neurotoxic effects. In an effort to delve into the cytotoxic impacts of nano-Cu, we ...
Priyanka Mazire,Disha Chaudhary,Kevin Thomas et al.
Priyanka Mazire et al.
Cancer continues to represent one of the most alarming global public health challenges, with its burden rising across both developed and developing nations. Therefore, it is essential to address this increasing global prevalence of cancer f...
Iodinated contrast agents decrease the activity of multidrug resistance protein, cell migration, and induce cell death in different tumor cell lines and glioblastoma spheroids [0.03%]
碘化对比剂降低多药耐药蛋白活性、细胞迁移并诱导不同肿瘤细胞系和胶质母细胞瘤类器官凋亡
Jessica Sodré Silva de Abreu,Morgana Teixeira Lima Castelo-Branco,Janaina Fernandes
Jessica Sodré Silva de Abreu
Iodinated contrast agents are a class of compounds widely used in diagnostic medicine to enhance images of tissues subjected to X-ray techniques. Previous studies have shown that radiocontrast agents are capable of increasing the generation...
Protist oxygen-sensing and the role of prolyl hydroxylase-regulation of E3(SCF) ubiquitin ligases [0.03%]
顶体氧感知及脯氨酰羟化酶调节E3（SCF）泛素连接酶的作用
Donovan A Cantrell,Ira J Blader,Christopher M West
Donovan A Cantrell
A primary mechanism for sensing O2 in animals involves the O2-dependent prolyl hydroxylase PHD2, which generates a degron on the transcription co-factor HIF-α. In protists, its apparent evolutionary predecessor, PhyA, is dedicated to the m...
Surface modifications of Ti-6Al-4 V discs modulate macrophage inflammatory response [0.03%]
Ti-6Al-4V圆盘的表面改性可调节巨噬细胞的炎性反应
Bo Cao,Ronny Mohren,Darya Hadavi et al.
Bo Cao et al.
Background: Transcription factors (TFs) regulate gene expression and coordinate key cellular processes, including proliferation, differentiation, and immune responses. NFATc1 is a central regulator of immune signaling, wh...