Modulation of glycosylation in the brain: A single-cell exploration of glycosidases using the Allen Brain Cell Atlas [0.03%]
利用艾伦人脑细胞图谱探索单细胞糖苷酶的糖基化调控
Sagar Dalal,Edward S X Moh,Nicolle H Packer
Sagar Dalal
The mammalian brain is enveloped in a dense, charge-rich glycocalyx that orchestrates cell signalling, migration, and synaptic stability. Transcriptomic explorations of this molecular interface have previously focussed on the complex enzyma...
A computationally optimized peptide (KI17) derived from Talisia esculenta with potent action against multidrug-resistant pathogens [0.03%]
一种来源于诃子具有抗多重耐药病原菌作用的优化多肽(KI17)
Ana Paula Ramos Pereira,Ana Cristina Jacobowski,Claudiane Vilharroel Almeida et al.
Ana Paula Ramos Pereira et al.
Antimicrobial peptides (AMPs) offer a promising solution against multidrug-resistant pathogens. However, their clinical application remains challenging due to limitations, including toxicity, proteolytic instability, and limited bioavailabi...
Introduction to the special issue on glycosyltransferases: Molecular targets and functions in health and disease [0.03%]
糖基转移酶专题介绍：健康与疾病中的分子靶点和功能
Naoyuki Taniguchi
Naoyuki Taniguchi
Selected calix[4]arene as an effective modulator of mitochondrial function and smooth muscle contractility [0.03%]
精选杯芳烃作为线粒体功能和平滑肌收缩的有效调节剂
Illia S Forys,Olga V Tsymbalyuk,Yurii V Danylovych et al.
Illia S Forys et al.
Macrocyclic nanocompounds, particularly calix[4]arenes, are attracting growing interest in biomedical and molecular biotechnology research. Calix[4]arene C-715, functionalized with trifluoroacetamide groups on the upper rim, does not affect...
ST6Gal1 influences the esophageal squamous cell carcinoma resistance to IFN-γ by regulating the expression of IFN-γ receptor 1 [0.03%]
ST6Gal1通过调节IFN-γ受体1的表达影响食管鳞癌细胞对IFN-γ的抗性
Kaixin Zhang,Nianzhu Zhang,Yingshu Zhang et al.
Kaixin Zhang et al.
ST6Gal1 (α2,6-sialyltransferase1), the primary glycosyltransferase catalyzing α2,6-sialylation of N-glycans, plays a pivotal role in the progression of various human cancers. However, the role of ST6Gal1-mediated α2,6-sialylation in huma...
Spatiotemporal regulation of N-glycosylation in the endoplasmic reticulum of mammalian cells [0.03%]
哺乳动物细胞内质网N-连接糖基化的时空调控
Yoichiro Harada
Yoichiro Harada
The translocation of nascent polypeptides across the endoplasmic reticulum membrane and their subsequent asparagine-linked glycosylation are fundamental processes in mammalian cells. Asparagine-linked glycosylation is catalyzed by the oligo...
Catalytic mechanism of a plant hydrolytic enzyme explained through its 50 crystal structures and counting - What have we learnt? [0.03%]
通过50种晶体结构阐明植物水解酶的催化机制——我们学到了什么？
Maria Hrmova
Maria Hrmova
Substrates and products bind and unbind in enzymes at prohibitive rates, which preclude investigations of reactant trajectories during catalytic cycles. To offset this lack of knowledge, we provide data based on 50 crystal structures of a p...
The unfolded protein response pathway mediates ovalbumin-induced innate immune response in Caenorhabditis elegans [0.03%]
未折叠蛋白反应途径介导了秀丽隐杆线虫 Ovalbumin 引发的先天免疫反应
Dong Liu,Kexin Yao,Haibing Pei et al.
Dong Liu et al.
Ovalbumin (OVA), the major allergen in egg white, is used as a model allergen in the studies of food allergy. Previous studies have confirmed that OVA can induce innate immune responses in Caenorhabditis elegans (C. elegans), and the expres...
Metabolite profiling identifies upregulation of specific glycerophospholipids and sphingolipids in imatinib-resistant cell lines [0.03%]
代谢轮廓鉴别出用伊马替尼治疗的耐药细胞系中特定甘油磷脂和鞘脂的上调
Divya Presingu,Sai Charitha Mullaguri,Vijayasarathy Ketavarapu et al.
Divya Presingu et al.
Chronic myeloid leukemia (CML) is effectively treated with imatinib, but a fraction of patients develop resistance. Although genetic alterations are known contributors, metabolic reprogramming has emerged as an additional driver. In this st...
Epoxyazadiradione, a neem-derived limonoid exhibits activities against pancreatic cancer through modulation of inflammatory molecules, lncRNAs, ROS, and EMT [0.03%]
从尼姆树中获得的环氧 Azadiradione 通过调节炎症分子、长链非编码 RNA、ROS 和上皮间质转化对胰腺癌具有活性
Vipin Rai,Ankit Srivastava,Anusmita Shekher et al.
Vipin Rai et al.
Pancreatic cancer is the seventh most prevalent cancer worldwide, with persistently low life expectancy that hasn't changed for many decades. Agents derived from Mother Nature has been emphasised for drug development due to their safety, af...