N-glycosylation remodeling in aging: Biomarkers and modulators of biological age across organ systems [0.03%]
衰老中的N-糖基化重塑：跨器官系统生物年龄的标志物和调节因子
Aswath Balakrishnan,Blake Krisko,Christofer Daniel Sánchez et al.
Aswath Balakrishnan et al.
Aging is characterized by progressive functional decline, increased disease susceptibility, and dysregulation of cellular homeostasis. Among post-translational modifications, N-glycosylation has emerged as a key regulator of protein stabili...
Targeting cancer cell sialylation with monosaccharide analogues modulates EGFR in colorectal cancer cells [0.03%]
单糖类似物靶向结直肠癌细胞岩藻糖基化以调控表皮生长因子受体
Jordan Gotti,Rosa do Vale,Henrique O Duarte et al.
Jordan Gotti et al.
Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide, mainly due to resistance to targeted therapies such as Cetuximab, a chimeric monoclonal antibody targeting epidermal growth factor receptor (EGFR) used ...
Balenine alleviates neurodegeneration and inflammation in a mouse model of Parkinson's disease [0.03%]
巴利奈肽减轻帕金森病小鼠模型的神经退行性病变和炎症反应
Yusaku Chukai,Konatsu Arisumi,Genta Yasunaga et al.
Yusaku Chukai et al.
Carnosine, an imidazole dipeptide, has potential for treating neurodegenerative diseases, including Parkinson's disease. However, carnosine-degrading enzymes limit its bioavailability. In this study, we established a mouse model of 1-methyl...
Limited involvement of MMP2, MMP9 and MMP14 in vasculogenic mimicry formation of human tumor cell lines [0.03%]
人类肿瘤细胞系血管生成模拟形成的MMP2、MMP9和MMP14的有限参与作用研究
Tomoki Yoshida,Emu Fukuoka,Ryota Kawahara et al.
Tomoki Yoshida et al.
Vasculogenic mimicry (VM) is a phenomenon in which tumor cells form capillary-like networks without endothelial cells and is associated with tumor progression and poor prognosis. Understanding mechanisms of VM and identifying its reliable b...
Impact of CSGALNACT1-mediated structural changes in chondroitin sulfate on tau seed uptake and pathological progression [0.03%]
CSGALNACT1介导的硫酸软骨素结构变化对tau蛋白病理核摄取及病程的影响
Satomi Nadanaka,Jun-Ichi Tamura,Hiroshi Kitagawa
Satomi Nadanaka
Chondroitin sulfate (CS) plays essential roles in neurodevelopment and brain aging. Alterations in glycosaminoglycan composition on the neuronal cell surface and within the extracellular matrix (ECM) contribute to the progression of tauopat...
Chitooligosaccharides enhance T-cell immunity via supporting the dominant growth of β-1,4-glycosidase-expressing Lactobacillus spp. in mice [0.03%]
鼠李糖低聚糖通过促进乳酸菌生长来增强T细胞免疫反应
Hui Fang,Muhammad Naveed,He Liu et al.
Hui Fang et al.
Chitooligosaccharides (COSs) are hydrolysates of chitosan polymers. COSs have many biological functions, especially in immune activation. Gut microbiota is closely related to the decomposition of natural glycans in the human intestine and p...
Exosome-derived mtDNA disrupts endothelial barrier integrity and accelerates sepsis progression by inducing mitochondrial dysfunction through the PKCδ gene [0.03%]
外泌体来源的线粒体DNA通过诱导PKCδ介导的线粒体功能障碍破坏内皮屏障完整性和加速脓毒症进展
Zhiyong Peng,Xiaojuan Cao,Hejun Gao et al.
Zhiyong Peng et al.
Sepsis, a severe inflammatory response to infection, is characterized by complex and rapidly evolving pathophysiology with high mortality. Mitochondrial DNA (mtDNA) in exosomes is a key damage-associated molecular pattern implicated in seps...
Selection and evaluation of new sites for splitting beta-lactamase to modulate auto-complementation enzyme activity [0.03%]
用于调节自动补全酶活性的β-内酰胺酶拆分新位点的选择与评价
Morgan C Marsh,Shawn C Owen
Morgan C Marsh
Split protein systems, including split fluorescent proteins and split enzymes, have predominantly been applied to monitor protein-protein interactions but have recently gained popularity as components in induced complementation diagnostic p...
Primase subunit 2 regulates the proliferation and apoptosis of gastric cancer cells via MCM7/CDK4 and Bax/Bcl-2 pathways [0.03%]
通过MCM7/CDK4和Bax/Bcl-2途径调控增殖和凋亡的胃癌细胞的原核DNA复制酶亚基2
Bingbing Liu,Xiansheng Wang,Yue Wang et al.
Bingbing Liu et al.
Background: PRIM2 (DNA primase subunit 2), a key regulator of DNA replication initiation, is aberrantly expressed in multiple cancer types and contributes to tumor progression. ...
POGLUT2 and POGLUT3: Two essential protein O-glucosyltransferases modifying EGF repeats in extracellular matrix proteins [0.03%]
POGLUT2和POGLUT3：两种对细胞外基质蛋白EGF重复结构域进行O-糖基化的必需的蛋白质O-糖基转移酶
Nicholas R Kegley,Bernadette C Holdener,Robert S Haltiwanger
Nicholas R Kegley
O-glycosylation of Notch epidermal growth factor-like (EGF) repeats has long been studied in the context of protein folding, secretion from cells, and protein function. Originally, the protein O-glucosyltransferase, POGLUT1, was thought to ...