Acquisition of stem associated-features on metastatic osteosarcoma cells and their functional effects on mesenchymal stem cells [0.03%]
恶性肿瘤干细胞相关特征的获得及其对间充质干细胞的功能影响
Matías Valenzuela Álvarez,Luciana M Gutiérrez,Jerónimo Auzmendi et al.
Matías Valenzuela Álvarez et al.
Background: Osteosarcoma (OS) is the most frequent malignant bone tumor, affecting predominantly children and young adults. Metastases are a major clinical challenge in OS. In this context, 20% of OS patients are diagnose...
Adaptation of striated muscles to Wolframin deficiency in mice: Alterations in cellular bioenergetics [0.03%]
Wolframin缺乏小鼠条纹肌的适应：细胞生物能量学的变化
Kersti Tepp,Marju Puurand,Natalja Timohhina et al.
Kersti Tepp et al.
Background: Wolfram syndrome (WS), caused by mutations in WFS1 gene, is a multi-targeting disease affecting multiple organ systems. Wolframin is localized in the membrane of the endoplasmic reticulum (ER), influencing Ca2...
Ezrin interacts with L-periaxin by the "head to head and tail to tail" mode and influences the location of L-periaxin in Schwann cell RSC96 [0.03%]
Ezrin通过“头对头和尾对尾”模式与L-periaxin相互作用并影响施万细胞RSC96中L-periaxin的位置
Tao Guo,Lei Zhang,Hong Xiao et al.
Tao Guo et al.
In the peripheral nervous system (PNS), Schwann cells (SCs) are required for the myelination of axons. Periaxin (PRX), one of the myelination proteins expressed in SCs, is critical for the normal development and maintenance of PNS. As a mem...
Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus [0.03%]
2017年巴西流行的黄病毒株的NS2B-NS3蛋白酶结构表征及多态性分析
Gabriela Dias Noske,Victor Oliveira Gawriljuk,Rafaela Sachetto Fernandes et al.
Gabriela Dias Noske et al.
Background: The Yellow Fever virus (YFV) is transmitted by mosquitos and causes an infection with symptoms including fever, headaches and nausea. In 20-50% of the cases, the disease may evolve to a visceral stage, reachin...
CLPB (caseinolytic peptidase B homolog), the first mitochondrial protein refoldase associated with human disease [0.03%]
CLPB（钙网蛋白裂解酶B同源物），第一个与人类疾病相关的线粒体蛋白质重折叠酶
Dagmara Mróz,Hubert Wyszkowski,Tomasz Szablewski et al.
Dagmara Mróz et al.
Identification and characterization of fragment binding sites for allosteric ligand design using the site identification by ligand competitive saturation hotspots approach (SILCS-Hotspots) [0.03%]
利用竞争饱和热点的位点鉴定和特征分析方法（SILCS-Hotspots）来鉴定别构配体设计的片段结合位点及其特性分析方法
Alexander D MacKerell Jr,Sunhwan Jo,Sirish Kaushik Lakkaraju et al.
Alexander D MacKerell Jr et al.
Background: Fragment-based ligand design is used for the development of novel ligands that target macromolecules, most notably proteins. Central to its success is the identification of fragment binding sites that are spat...
Characterization of Macrophage Galactose-type Lectin (MGL) ligands in colorectal cancer cell lines [0.03%]
结肠直肠癌细胞系中巨噬细胞半乳糖型凝集素（MGL）配体的表征
Martina Pirro,Yoann Rombouts,Alexandre Stella et al.
Martina Pirro et al.
Background: The Ca2+-dependent C-type lectin receptor Macrophage Galactose-type Lectin (MGL) is highly expressed by tolerogenic dendritic cells (DC) and macrophages. MGL exhibits a high binding specificity for terminal al...
Four countries for science [0.03%]
四国共推科学项目
Jeremy C Smith
Jeremy C Smith
A personal retrospect is given on four decades in science in four countries - the UK, France, Germany and the USA. Some historical observations are made together with a time transect through scientific systems and institutions in the four c...
A novel Xanthomonas citri subsp. citri NADPH quinone reductase involved in salt stress response and virulence [0.03%]
一种参与盐胁迫响应和致病性的柑橘黄单胞菌天冬酰胺合成酶NADPH辅酶Q还原酶的新蛋白
Maria Victoria Barcarolo,Betiana S Garavaglia,Natalia Gottig et al.
Maria Victoria Barcarolo et al.
Background: Xanthomonas citri subsp. citri (Xcc), the causal agent of citrus canker is maintained as an epiphyte on citrus leaves until entering the plant tissue. During epiphytic survival, bacteria may encounter low wate...