SLC27A5 deficiency-induced reduction in long-chain fatty acid uptake is a pro-tumorigenic metabolic adaptation and confers sensitivity to glutaminase inhibition in hepatocellular carcinoma [0.03%]
SLC27A5缺陷导致的长链脂肪酸摄取减少是肝细胞癌中的促肿瘤代谢适应并使谷氨酰胺酶抑制敏感性增强
Xiaoyan He,Zhengwei Zhao,Teng Wei et al.
Xiaoyan He et al.
Hepatocellular carcinoma (HCC) exhibits diminished capacity for oxidative utilization of long-chain fatty acids (LCFAs). However, the strategic and mechanistic basis by which HCC cells enact metabolic reprogramming to adapt to impaired LCFA...
Cannabidiol alleviates chemotherapy-induced cognitive decline and neuropathology [0.03%]
大麻二酚可缓解化疗引起的认知功能下降和神经病理学损伤
Shreya Madan,Sanad M El-Khatib,Asrita Prathigudupu et al.
Shreya Madan et al.
Chemotherapy is frequently associated with long-term cognitive impairments in cancer survivors that negatively impact their quality of life. Effective mitigation strategies for cancer therapy-related cognitive impairments (CRCI) are still u...
LINC01186-mediated deubiquitination of ACSL4 reprograms lipid metabolism to increase autophagy-mediated angiogenesis in colorectal cancer [0.03%]
长非编码RNA LINC01186通过去泛素化ACSL4重新编程脂质代谢以增加结直肠癌中自噬介导的血管生成
Jie Li,Qian Luo,Caihong Xu et al.
Jie Li et al.
Angiogenesis supports colorectal cancer (CRC) proliferation and metastasis, yet how lipid metabolic reprogramming intersects with angiogenesis signaling remains unclear. Here, we found that LINC01186 is upregulated in CRC and correlates wit...
SLC30A7 phosphorylation by ERK1 promotes esophageal squamous cell carcinoma tumorigenesis via activating MMP2/3/9-β-catenin signaling [0.03%]
ERK1通过激活MMP2/3/9-β-catenin信号促进食管鳞状细胞癌发生发展的SLC30A7磷酸化研究
Lu Yang,Ning Yao,Liting Zhou et al.
Lu Yang et al.
Zinc ions (Zn2+) are crucial for cellular homeostasis, with their intracellular concentrations tightly regulated by multiple zinc transporters located at the plasma and organelle membranes. Zinc dysregulation has been implicated in esophage...
From linker stability to linker fitness: redefining ADC design for clinical translation [0.03%]
从连接物稳定性到连接物适应性：重新定义ADC设计以实现临床转化
Wenxue Ma,Emma Klacking,Catriona Jamieson
Wenxue Ma
Exosome mediated crosstalk in gastrointestinal cancers progression: special focus on Integrin β3 as a cargo [0.03%]
胃肠癌症进展中的外泌体介导的通讯：特别关注整合素β3作为载物
Ganji Purnachandra Nagaraju,Sujith Sarvesh,Bassel F El-Rayes
Ganji Purnachandra Nagaraju
Intercellular communication within the tumor microenvironment (TME) is highly active in gastrointestinal (GI) cancers, and exosomes have an important function in tumor development, progression, metastasis, angiogenesis, and drug resistance....
RAC1 signaling in polyploid giant cancer cells: Implications for tumorigenesis and therapy resistance [0.03%]
多倍体巨癌细胞中RAC1信号的传导：对肿瘤发生及治疗抗性的启示
Lakshmi Kavitha Sthanam,Paola Miranda Mendez,Elena McBeath et al.
Lakshmi Kavitha Sthanam et al.
Polyploid giant cancer cells (PGCCs) are a subpopulation of tumor cells known for driving tumor recurrence, metastasis, and therapeutic resistance. PGCCs arise mainly in response to cellular stress induced by cancer therapies and adverse mi...
Pharmacological induction of mitochondria-lysosome hyper-tethering elicits synthetic lethality in glioblastoma [0.03%]
药理学诱导线粒体溶酶体过度贴近以在胶质母细胞瘤中诱发合成致死效应
Dongyuan Su,Yanping Huang,Biao Hong et al.
Dongyuan Su et al.
The clinical translation of synthetic lethality between cytoplasmic phospholipase A2 (cPLA2) and dipeptidyl peptidase 4 (DPP4) in glioblastoma (GBM) has been hindered by the absence of clinically applicable cPLA2 inhibitors. In this study, ...
Yashwardhan Ghanwatkar,Raghu Ramanathan,Ram I Mahato
Yashwardhan Ghanwatkar
Pancreatic ductal adenocarcinoma (PDAC) remains among the most lethal solid malignancies, and its therapeutic failure reflects both aggressive tumor-cell biology and the highly restrictive tumor microenvironment (TME). A defining hallmark o...
Repurposing the Neurokinin-1 Receptor Antagonist Aprepitant to Eradicate Relapsed/Refractory Acute Lymphoblastic Leukemia via Mitochondria-Driven Necroptosis [0.03%]
将神经激肽-1受体拮抗剂阿普利玛尼重新定位为通过线粒体驱动的坏死性凋亡来根除复发/难治性急性淋巴细胞白血病
Gang Shao,Hanling Pan,Jiayi Zhu et al.
Gang Shao et al.
The prognosis for relapsed/refractory acute lymphoblastic leukemia (R/R ALL) remains dismal due to intrinsic and acquired chemoresistance, highlighting an urgent need for novel therapeutic strategies. The neurokinin-1 receptor (NK-1R) repre...