Changing Landscape in Stage, Treatment and Survival of Gastric Cancer in China 1998-2022: Insights of 40,158 patients from the National Gastric Cancer Cohort [0.03%]
中国胃癌的发病、治疗和生存现状及预后（1998年-2022年）——全国胃癌队列40158例患者分析
Lulu Zhao,Zhihao Chen,Fan Zhang et al.
Lulu Zhao et al.
Introduction: Assessing progress in cancer control at the national level is crucial, as it offers key insights into the overall effectiveness of the health system. Here, we aimed to describe 20-year trends in stage distri...
Targeting the DDX3/PAF1 Axis Enhances Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma [0.03%]
靶向DDX3/PAF1轴可增强化疗在胰腺导管腺癌中的疗效
Palanisamy Nallasamy,Parthasarathy Seshacharyulu,Sanchita Rauth et al.
Palanisamy Nallasamy et al.
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that has a poor survival rate of ∼13% with limited options for effective therapies. DDX3 is a member of the DEAD-box RNA helicase enzyme family. It acts as an adapter protein t...
Dysregulation of the ALDH1A3/PML-RARα axis promotes the progression of acute promyelocytic leukemia [0.03%]
醛氢酶1家族成员A3-PML-RARα轴的失调促进急性早幼粒细胞白血病的发展
Jiao Cai,Cheng-Hui Liang,Li-Ping Han et al.
Jiao Cai et al.
Dysfunction of the retinoic acid (RA) signaling pathway, which is mediated by the formation of the PML-RARA fusion gene, plays a central role in the pathogenesis of acute promyelocytic leukemia (APL). The activation of this pathway depends ...
Copper ionophores drive divergent responses to immune checkpoint inhibition across colorectal tumor models [0.03%]
铜离子载体驱动不同结直肠肿瘤模型对免疫检查点抑制的不同反应
Devon Heroux,Xu Xin Sun,Sijie Zhang et al.
Devon Heroux et al.
Copper-binding agents can trigger immunogenic cell death (ICD) and modulate responses to immune checkpoint inhibitors (ICIs), but how tumor copper biology, agent chemistry, and tumor microenvironment shape these effects is unclear. We evalu...
NR4A2 induces perineural invasion in head and neck squamous cell carcinoma and pancreatic ductal adenocarcinoma via CXCL5/CXCR2 signaling axis [0.03%]
NR4A2通过CXCL5/CXCR2信号轴诱导头颈鳞状细胞癌和胰腺导管腺癌的癌周神经侵犯
Sanjib Chaudhary,Muthamil Iniyan Appadurai,Koelina Ganguly et al.
Sanjib Chaudhary et al.
Perineural invasion (PNI) is associated with worse prognosis in various malignancies. Targeting PNI may hinder the tumor metastasis in head and neck squamous cell carcinoma (HNSCC) and pancreatic ductal adenocarcinoma (PDAC). We investigate...
Exosomal circUBR5 drives metastasis and chemoresistance in gastric signet-ring cell carcinoma by reprogramming cholesterol metabolism through the hsa-miR-1208/CYP19A1 axis and ACAT1 upregulation [0.03%]
外泌体circUBR5通过hsa-miR-1208/CYP19A1轴和ACAT1上调重塑胆固醇代谢驱动胃印戒细胞癌转移和耐药性
Yujuan Jiang,Zitong Zhao,Liying Ma et al.
Yujuan Jiang et al.
Gastric signet-ring cell carcinoma (GSRCC) exhibits a poor prognosis because of its aggressive behavior and chemoresistance, which is strongly associated with dysregulated cholesterol metabolism. This study investigated the role of circUBR5...
Succinate dehydrogenase B palmitoylation promotes T cell exhaustion through the H3K27ac-PD1 axis in pancreatic cancer [0.03%]
丙酮酸脱氢酶B棕榈酰化通过H3K27ac-PD1轴促进胰腺癌T细胞衰竭
Fuxin Huang,Cheukfai Li,Yue Chen et al.
Fuxin Huang et al.
Palmitoyltransferase ZDHHC5 (DHHC5) is a palmitoylation regulator that adds palmitate to various protein substrates. Its role in pancreatic cancer (PC) remains unclear, thus posing significant challenges to the promotion of the "cold tumor"...
FIG4 Downregulation-Arrested Autophagy-lysosomal Degradation of IL-18 Drives Lipid-Associated Macrophage Polarization and Immunotherapy Resistance in Triple-Negative Breast Cancer [0.03%]
图4下调所致的自噬-溶酶体IL-18降解受阻驱动与脂质相关巨噬细胞极化和三阴性乳腺癌免疫疗法耐药性增强有关
Fada Xia,Xudong Zhu,Xiaoyan Li et al.
Fada Xia et al.
Factor-induced gene 4 (FIG4) has been recently identified as a lipid-modifying enzyme that plays an important role in controls autophagolysosomal activity. However, the regulatory mechanisms and biological functions of FIG4 in cancer therap...
Loss of TFAM Accelerates Pentose Phosphate Pathway by Unleashing G6PD Oligomerization to Drive Hepatocarcinogenesis [0.03%]
TFAM缺失通过释放G6PD寡聚化加速戊糖磷酸途径以促进肝细胞癌发生发展
Xiaoxiao Zhu,Wanli Ma,Xiaoying Ji et al.
Xiaoxiao Zhu et al.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, characterized by complex pathogenesis and limited early diagnostic markers. Multi-omics analyses of mice and patients with primary liver tumors reveal ...
Midkine (MDK) as a Central Regulator of the Tumor Microenvironment: From Developmental Cytokine to Therapeutic Target [0.03%]
.midkine（MDK）作为肿瘤微环境的中央调节因子：从发育细胞因子到治疗靶点
Hareesh B Nair,Ajay Nair,Ya-Guang Liu et al.
Hareesh B Nair et al.
Midkine (MDK) is an oncofetal, heparin-binding cytokine that is re-expressed across diverse cancers and correlates with aggressive disease and treatment resistance. This review synthesizes current evidence on MDK as a coordinator of tumor-i...