BMP9 Potentiates Immunotherapy in Triple-Negative Breast Cancer by Suppressing Tregs Infiltration via the PRKDC-CCL2 Axis [0.03%]
BMP9通过PRKDC-CCL2轴抑制Tregs浸润从而增强三阴性乳腺癌免疫治疗效果
Yiqing You,Lan Wei,Meng Dai et al.
Yiqing You et al.
Immunotherapy represents a pivotal strategy for triple-negative breast cancer (TNBC), yet its efficacy is constrained by the immunosuppressive tumor microenvironment (TME). In this study, we demonstrate that bone morphogenetic protein-9 (BM...
Hypoxia-Related CircARSB Modulates Lipid Metabolism and Innate Immune Crosstalk to Influence Immune Checkpoint Inhibitor Response in Hepatocellular Carcinoma [0.03%]
缺氧相关环状circar sb通过调节脂代谢和固有免疫互作影响肝癌免疫检查点抑制剂治疗响应
Lina Song,Jialiang Cai,Guiqi Zhu et al.
Lina Song et al.
Intratumoral heterogeneity (ITH) in hepatocellular carcinoma (HCC), driven by malignant cells plasticity, underlies differential responses to immune checkpoint inhibitors (ICIs). Single-nucleus sequencing revealed that hypoxic stress regula...
G6PD+CSV+ circulating tumor cells associated with portal vein tumor thrombus formation via EMT-ferroptosis crosstalk: a dual biomarker for therapeutic efficacy and prognosis prediction in hepatocellular carcinoma [0.03%]
G6PD和CSV通过上皮间质转化-铁死亡串扰与门静脉癌栓相关：肝细胞癌治疗效果和预后预测的双重生物标志物
Lujun Chen,Heming Li,Qiuhua Luo et al.
Lujun Chen et al.
Portal vein tumor thrombus (PVTT) is a major contributor to recurrence, metastasis, and poor prognosis in hepatocellular carcinoma (HCC). Effective early detection and therapeutic strategies for PVTT are lacking. In our ongoing investigatio...
Strategies to optimize duration of immunotherapy in advanced NSCLC: Current evidence and future directions [0.03%]
免疫治疗用于晚期NSCLC的疗程优化策略：现有证据与未来方向
Xue Dong,Ruyue Li,Xiujing Yao et al.
Xue Dong et al.
Immune checkpoint inhibitors have revolutionized the treatment of advanced non-small cell lung cancer, yet the optimal duration of therapy remains uncertain, raising concerns about cumulative toxicity, economic burden, and potential overtre...
Corrigendum to "Bimodal silencing of the acinar cell-specific mRNA translation repressor PAIP2B defines a poor prognostic subgroup within the classical pancreatic tumor type" [Cancer Lett. 632 (2025) 217971] [0.03%]
“胰腺肿瘤经典型中的不良预后亚组由小导管细胞特异性翻译抑制因子PAIP2B的双峰沉默定义”一文中关于PAIP2B的双峰沉默定义了经典型胰腺肿瘤中的不良预后亚组的勘误[Cancer Lett. 632 (2025) 217971]
Eulalie Corre,Amandine Alard,Catherine Marbœuf et al.
Eulalie Corre et al.
Published Erratum
Cancer letters. 2025 Dec 3:218202. DOI:10.1016/j.canlet.2025.218202 2025
SRC at the crossroads of KRAS inhibitor resistance: Mechanisms and therapeutic opportunities [0.03%]
SRC处于抗KRAS抑制剂药物耐药的十字路口：机制与治疗机会
Hui Tian,Dan Zhao,Zhuan Zhou et al.
Hui Tian et al.
Kirsten rat sarcoma (KRAS) mutations are among the most common oncogenic drivers in human cancers, particularly in non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and pancreatic ductal adenocarcinoma (PDAC). The development of ...
Cytoplasmic SIRT1 enhances the stemness of polyploid giant cancer cells by promoting β-catenin protein stability and nuclear accumulation in ovarian carcinoma upon neoadjuvant chemotherapy [0.03%]
化疗诱导的卵巢癌巨核肿瘤干细胞样亚群中SIRT1通过促进β-连环蛋白蛋白稳定性和核积累来增强多倍体巨细胞的干性属性
Hong Xu,Shujun Zeng,Minmin Wang et al.
Hong Xu et al.
Epithelial ovarian carcinoma, the deadliest gynecological malignancy, frequently develops treatment resistance through polyploid giant cancer cells (PGCCs) that typically emerge after carboplatin-paclitaxel chemotherapy. Accumulating eviden...
Copper orchestrates triple-negative breast cancer progression via the STEAP3-dependent CDK16-JAK1 activation [0.03%]
铜通过STEAP3依赖的CDK16-JAK1活化调控三阴性乳腺癌进展
Fangfang Duan,Chao Zhang,Zichao Wu et al.
Fangfang Duan et al.
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, characterized by high recurrence rates and limited treatments beyond chemotherapy. The interplay between tumor cells and the tumor microenvironment plays a c...
Updated Clinical practice guidelines for the management of adult diffuse gliomas [0.03%]
成人弥漫性胶质瘤管理临床实践指南更新
Tao Jiang,Do-Hyun Nam,Zvi Ram et al.
Tao Jiang et al.
It has been five years since the last version of the clinical practice guidelines for the management of adult diffuse gliomas was published by the Asian Glioma Genome Atlas (AGGA). Significant progress and revisions have occurred in the dia...
Overcoming Radioresistance in Prostate Cancer by Targeting DNA Damage Repair [0.03%]
靶向DNA损伤修复以克服前列腺癌的放疗抗性
Ana Catarina Matos,Maria Lima,Vera Miranda-Gonçalves et al.
Ana Catarina Matos et al.
Prostate cancer (PCa) remains one of the most prevalent malignancies among men, with radiotherapy (RT) serving as a cornerstone of treatment. However, radioresistance (RR) remains a major clinical challenge, contributing to treatment failur...