Pharmacologic Inhibition of SOX9-CDK4 by CYD-4-61 Impairs Gastric Adenocarcinoma Growth and Amplifies Anti-PD-1 Response [0.03%]
SOX9-CDK4的药理学抑制剂CYD-4-61可妨碍胃腺癌生长并增强抗PD-1反应
Gengyi Zou,Katsuhiro Yoshimura,Yibo Fan et al.
Gengyi Zou et al.
Gastric adenocarcinoma (GAC) remains a leading cause of cancer-related mortality, particularly in patients with peritoneal carcinomatosis, for whom effective therapies are limited. We investigated the therapeutic efficacy and molecular mech...
Tumor-derived CDHR2-enriched extracellular vesicles engage ANPEP on liver sinusoidal endothelial cells to facilitate transendothelial migration in PDAC [0.03%]
肿瘤衍生的CDHR2富集的细胞外囊泡与肝窦状内皮细胞上的ANPEP结合，以促进胰腺导管腺癌的穿膜迁移
Rui Wang,Yi Wang,Shuting Xiao et al.
Rui Wang et al.
Liver metastasis is the leading cause of death in pancreatic ductal adenocarcinoma (PDAC), yet its molecular drivers remain poorly defined. Through integrated transcriptomic and proteomic screening of clinical specimens, we identify the mem...
Tumoral AMER1 driven dopamine synthesis triggers cancer cell pyroptosis and licenses CD8+ T cell immunity in colorectal cancer [0.03%]
肿瘤性AMER1驱动的多巴胺合成触发结直肠癌细胞焦亡并激活CD8+T细胞免疫反应
Jun Long Dang,Qi Hu,Yang Lu et al.
Jun Long Dang et al.
While classical tumor suppressors in colorectal cancer (CRC) are predominantly recognized for restraining cell-autonomous proliferation, their extrinsic mandate in orchestrating the tumor immunometabolic niche remains poorly defined. Clinic...
Induction of cuproptosis via targeting mitochondrial metabolism using dPTBD with potent therapeutic activity against KRAS-driven cancer [0.03%]
利用dPTBD靶向线粒体代谢以诱导铜死亡并针对KRAS驱动的癌症进行治疗
Yichen Sun,Ming Song,Wenwen Ding et al.
Yichen Sun et al.
Cuproptosis is a type of recently reported cell death characterized by aberrant accumulation of copper ions within cells, leading to mitochondrial stress and protein aggregation. Recent studies suggest that certain cancer cells are particul...
Vitamin D deficiency alters prostate epithelial differentiation and increases prostate cancer aggressiveness in ex vivo and in vivo models [0.03%]
维生素D缺乏可改变前列腺上皮分化并增加前列腺癌的恶性度：体外和体内模型研究
Adriana Duraki,Kirsten D Krieger,Sasha Celada et al.
Adriana Duraki et al.
Here, we examined the consequences of biologically relevant vitamin D deficiency, a known risk factor for aggressive prostate cancer, using ex vivo and in vivo models. Phenotypic and single-cell RNA sequencing of mouse prostate organoids sh...
Therapy-Associated Lineage Plasticity in DIPG Following Combined CDK4/6 Inhibitor, Temozolomide, and Radiation [0.03%]
联合使用CDK4/6抑制剂、替莫唑胺和放疗后DIPG的治疗相关谱系可塑性
Zilu Huang,Tongchao Jiang,Milagros M Suarez Palacios et al.
Zilu Huang et al.
Diffuse intrinsic pontine glioma (DIPG) is a highly lethal and therapeutically refractory pediatric brain tumor, and the effects of distinct disease backgrounds on treatment response and residual cell-state plasticity remain poorly understo...
Ultrasound-targeted nanodroplets destruction activates CAF_Pi16-CCL7 signalling to enhance NKG2D expression and overcome ICB resistance in MSS CRC [0.03%]
超声靶向破坏纳米液滴激活CAF_Pi16-CCL7信号，增强NKG2D表达并克服微卫星稳定型结直肠癌ICB耐药性
Baojing Tuo,Na Li,Senbo Liu et al.
Baojing Tuo et al.
Immune-resistant colorectal cancer (irCRC), represented by microsatellite stable/proficient mismatch repair (MSS/pMMR) tumors, responds poorly to immune checkpoint blockade (ICB). Here, we developed an ultrasound-targeted nanodroplet destru...
Elevated FN14 expression promotes proliferation, chemoresistance, and impairment of differentiation in rhabdomyosarcoma [0.03%]
FN14高表达促进横纹肌肉瘤细胞增殖、耐药及分化障碍
Anh Tuan Vuong,Xiaoxiao Yang,Niraj K Sah et al.
Anh Tuan Vuong et al.
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in children and adolescents and is characterized by expression of myogenic regulatory factors without terminal differentiation. Treatment of RMS remains challenging, with near...
Prognostic and Predictive Values of Transcriptomic Signatures in Metastatic Pancreatic Cancer: A Biomarker Analysis of Three French Multicenter Prospective Randomized Controlled Phase 2 Trials (Prodige35, Prodige37 and AFUGEM) [0.03%]
法国三项多中心前瞻性随机对照Ⅱ期试验（PRODIGE35、PRODIGE37和AFUGEM）中转移性胰腺癌转录谱标志物的预后及预测价值的生物标志物分析
Shulin Zhao,Remy Nicolle,Julien Taieb et al.
Shulin Zhao et al.
To evaluate the clinical applicability of previously established transcriptomic signatures (molecular subtypes, components and GemPred status) in metastatic pancreatic cancer, we conducted a retrospective pooled analysis of 178 patients fro...
Deciphering CD8+ T cell exhaustion in human cancers through single-cell and spatial transcriptomics [0.03%]
通过单细胞和空间转录组学解码人类癌症中CD8+T细胞耗竭
Zi-Xuan Gou,Xiao-Jun Huang,Xiang-Yu Zhao
Zi-Xuan Gou
Exhausted CD8+ T cells (Tex) within the tumor microenvironment (TME) represents a critical barrier limiting anti-tumor immune responses. Tex cells are characterized by upregulated inhibitory immune checkpoint receptors, reduced cytotoxicity...