Cellular plasticity and myeloid inflammation in the adult brain are independent of the transcriptional modulator DREAM [0.03%]
成人脑中的细胞可塑性和髓样炎症与转录调节因子DREAM无关
Rebecca Katharina Masanetz,Wolfgang Baum,Georg Schett et al.
Rebecca Katharina Masanetz et al.
The downstream regulatory element antagonist modulator (DREAM) modulates ion channel function and gene transcription. Functionally, DREAM is implicated in physiological and pathological processes including cell proliferation, inflammation, ...
The murine ortholog of Kaufman oculocerebrofacial syndrome gene Ube3b is crucial for the maintenance of the excitatory synapses in the young adult stage [0.03%]
卡夫曼眼脑面综合征基因Ube3b的小鼠同源物对于年轻成年期兴奋性突触的维持至关重要
Saki Katsube,Noriko Koganezawa,Kenji Hanamura et al.
Saki Katsube et al.
Kaufman oculocerebrofacial syndrome (KOS) is an autosomal recessive developmental disorder. Inactivating mutations in UBE3B, an E3 ubiquitin ligase gene are causative for KOS. We have reported that towards postnatal week three, its murine o...
Tunicamycin induces depression-like behaviors in male rats, accompanied by initiated chaperon-mediated autophagy and decreased synaptic protein expression in the hippocampus [0.03%]
链霉素诱导雄性大鼠产生类似抑郁的行为，伴随分子伴侣介导的自噬启动及海马区突触蛋白表达降低
Guohao Yuan,Ling Xiao,Yinping Xie et al.
Guohao Yuan et al.
Background and aim: Endoplasmic reticulum (ER) stress participates in the occurrence and development of depression, but the underlying mechanism is not fully understood. This study aimed to investigate the behavioral perf...
Hend Omara-Reda,Omar Ouachikh,Dhouha Hamdi et al.
Hend Omara-Reda et al.
Tramadol is one of the most commonly prescribed analgesic opioids in various pharmacopeias. Tramadol has been linked to abuse in recent clinical investigations. However, the behavioral effects and neural substrates of the drug have not been...
Effects of acupuncture on regulating the hippocampal inflammatory response in rats exposed to post-traumatic stress disorder [0.03%]
针灸对创伤后应激障碍大鼠海马区炎性反应的调节作用
Huili Jiang,Lu Chen,Yufei Li et al.
Huili Jiang et al.
Data from clinical and experimental studies have verified the efficacy and safety of acupuncture in the treatment of post-traumatic stress disorder (PTSD). However, the concrete mechanism has not been well elucidated. The stress-induced act...
Neuroimaging mechanisms in short-term heroin- and methamphetamine-abstinent users: Similarities and differences [0.03%]
短期海洛因和冰毒戒断使用者的神经影像机制：相似与差异
Mingqiang Gong,Wenbin Liang,Chunxue He et al.
Mingqiang Gong et al.
Heroin and methamphetamine cause great damage to individuals and society. However, numerous withdrawal mechanisms remain unidentified. In this study, 19 heroin short-term abstinent (HSTA) patients, 20 methamphetamine short-term abstinent (M...
Effects of intra-nasal melanocortin-4 receptor antagonist on trigeminal neuropathic pain in male and female rats [0.03%]
鼻内黑素皮质激素4受体拮抗剂对雄性和雌性大鼠三叉神经病理性疼痛的影响
Olga Anna Korczeniewska,Kalyani Tatineni,Shanzae Faheem et al.
Olga Anna Korczeniewska et al.
Treatment of chronic orofacial pain remains a major therapeutic challenge despite available medications. Melanocortins have been implicated in pathologic pain. Intrathecal administration of MC4R antagonists has been shown to alleviate neuro...
Effect of sleep deprivation on postural control and dynamic stability in healthy young adults [0.03%]
睡眠剥夺对健康年轻成人姿势控制和动态稳定的影响
Camila G M Castor,Thiago R T Santos,Thales R Souza et al.
Camila G M Castor et al.
Background: Postural control results from non-linear interactions of multiple neuromusculoskeletal elements and contextual factors. The use of non-linear analyses that consider the temporal evolution of postural adjustmen...
APOE ε4 status and plasma p-tau181 interact to influence cognitive performance among non-demented older adults [0.03%]
APOE ε4状态和血浆p-tau181相互影响非痴呆老年人的认知表现
Shanshan Wang,Shaofa Ke,Suzhi Liu et al.
Shanshan Wang et al.
Objective: In this study, we aimed to investigate the relationships among plasma p-tau181, APOE ε4, and cognitive performance in non-demented elderly individuals. ...
Microglia participate in postoperative cognitive dysfunction by mediating the loss of inhibitory synapse through the complement pathway [0.03%]
小胶质细胞通过补体途径介导抑制性突触丢失参与术后认知功能障碍
Xiaoxiang Tan,Jiajia Wang,Juan Yao et al.
Xiaoxiang Tan et al.
Background: Elderly patients after surgery are prone to cognitive decline known as postoperative cognitive dysfunction (POCD). Several studies have shown that the microglial activation and the increase of complement prote...