Acute deep brain stimulation of the paraventricular nucleus of the hypothalamus increases brown adipose tissue thermogenesis in rats [0.03%]
丘脑室旁核急性深部刺激增加棕色脂肪组织产热作用
Clarissa M D Mota,Dominic A Siler,Kim J Burchiel et al.
Clarissa M D Mota et al.
Brown adipose tissue (BAT) activity is controlled by the sympathetic nervous system. Activation of BAT has shown significant promise in preclinical studies to elicit weight loss. Since the hypothalamic paraventricular nucleus (PVN) contribu...
TMT-based proteomics profile reveals changes of the entorhinal cortex in a kainic acid model of epilepsy in mice [0.03%]
基于TMT的蛋白质组学揭示癫痫小鼠内侧颞叶病理机制中的新蛋白标志物
Jie Liu,Fenglin Tang,Danmei Hu et al.
Jie Liu et al.
Experimental modeling and clinical neuroimaging of patients has shown that certain seizures are capable of causing neuronal death. Research into cell death after seizures has identified the induction of the molecular machinery of apoptosis....
The expression of p27 in the adult vestibular sensory organs and its possible roles [0.03%]
成人前庭感觉器官中p27的表达及其可能作用
Yikang Huang,Qin Zhou,Wenyan Li et al.
Yikang Huang et al.
Vestibular hair cells (HCs) located in the inner ear are the receptors of vestibular sensory, which facilitates the human sense of balance. The detailed differentiation pattern and maturation process of the vestibular HCs are unclear now. p...
Loss of SV2A promotes human neural stem cell apoptosis via p53 signaling [0.03%]
SV2A丢失通过p53信号促进人神经干细胞凋亡
Hongxiang Yu,Yingying Han,Can Cui et al.
Hongxiang Yu et al.
This study investigated the role of synaptic vesicle protein 2A (SV2A) in the regulation of human induced pluripotent stem cell-derived neural stem cells (NSCs). SV2A was highly expressed in NSCs. SV2A knockdown promotes apoptosis, which wa...
Effects of constitutively active K-Ras on axon regeneration after optic nerve injury [0.03%]
激活的K-Ras对视神经损伤后轴突再生的影响
Naoki Kiyota,Kazuhiko Namekata,Euido Nishijima et al.
Naoki Kiyota et al.
Visual disturbance after optic nerve injury is a serious problem. Attempts have been made to enhance the intrinsic ability of retinal ganglion cells (RGCs) to regenerate their axons, and the importance of PI3K/Akt and RAF/MEK/ERK signal act...
Altered large-scale internetwork functional connectivity in patients with vestibular migraine and migraine without aura [0.03%]
前庭性偏头痛和无先兆偏头痛患者的大范围功能连接异常
Bing Zhang,Dongpeng Wu,Yonghua Guo et al.
Bing Zhang et al.
Objective: To investigate large-scale internetwork functional connectivity in patients with vestibular migraine (VM) and migraine without aura (MwoA). Met...
Peripheral administration of neuropeptide W inhibits gastric emptying in rats: The role of small diameter afferent fibers and cholecystokinin receptors [0.03%]
周围给予神经肽W通过小直径传入纤维和胆囊收缩素受体抑制大鼠胃排空
Sevil Arabacı Tamer,Berrak Ç Yeğen
Sevil Arabacı Tamer
Neuropeptide W (NPW), a novel hypothalamic peptide, contributes to the central regulation of food intake and energy balance, and suppresses feeding behavior when administered centrally. The aim of our study was to investigate the role of pe...
FoxP2 protein decreases at a specific region in the chick midbrain after hatching [0.03%]
鸡出壳后鸟脑中特定区域的FoxP2蛋白降低
Chikafusa Bessho,Shunji Yamada,Takashi Tanida et al.
Chikafusa Bessho et al.
Forkhead-box subclass P member 2 (FOXP2/FoxP2) protein, a transcription factor, regulates the development of certain brain functions, including human speech and animal vocalization. Although rapid progress has been made in demonstrating a r...
Temporal dynamics of brain BDNF expression following a single bout of exercise: A bioluminescence imaging study [0.03%]
单次运动后脑源性神经营养因子动态变化：一种发光成像研究
Takahiro Inoue,Ryo Ikegami,Yasuyuki Takamatsu et al.
Takahiro Inoue et al.
Physical exercise increases brain-derived neurotrophic factor (BDNF) expression in the brain. However, the absence of non-invasive and repetitive monitoring of BDNF expression in the brains of living animals has limited the understanding of...
Reduced SUMOylation of Nrf2 signaling contributes to its inhibition induced by amyloid-β [0.03%]
由淀粉样蛋白-β诱导的Nrf2信号抑制与Nrf2泛素化修饰下调有关
Peng Wang,Xiaoxuan Wang,Ke Qiao et al.
Peng Wang et al.
Oxidative stress induced by amyloid-β (Aβ) has been considered as one of the important mechanisms in the development of Alzheimer disease (AD). The inhibition of endogenous antioxidant Nrf2 signaling in the brain of AD patients aggravates...