Time-course effects and mechanisms of hypobaric hypoxia on nervous system in mice [0.03%]
低气压缺氧对小鼠神经系统的时间效应及机制研究
Huiting Zhang,Xianxie Zhang,Zuoxu Liu et al.
Huiting Zhang et al.
Objective: The aim of this study was to investigate the effect of time course on neurological impairment after acute hypobaric hypoxia exposure in mice and clarify the mechanism of acclimatization, so as to provide a suit...
Sevoflurane preconditioning improves neuroinflammation in cerebral ischemia/reperfusion induced rats through ROS-NLRP3 pathway [0.03%]
异氟烷预处理通过ROS-NLRP3信号途径改善脑缺血再灌注损伤大鼠神经炎症反应
Shujun Shang,Fengqiang Sun,Yulin Zhu et al.
Shujun Shang et al.
Aim: We aimed to study the influence of sevoflurane on the nucleotide-binding domain and Leucine-rich repeat protein 3 (NLRP3) pathways in rats with cerebral ischemia/reperfusion (I/R) injury. ...
A meta-analysis of exercise intervention and the effect on Parkinson's Disease symptoms [0.03%]
运动干预对帕金森病症状影响的meta分析研究
Syed Omar Ahmad,Jason Longhurst,Dana Stiles et al.
Syed Omar Ahmad et al.
Parkinson's disease (PD) is a progressive neurodegenerative disease that is distinguished by tremors at rest, bradykinesia, hypokinesia, and postural instability, resulting in a progressive decline in performance of everyday activities. The...
BMP9 ameliorates amyloid pathology by promoting low-density lipoprotein receptor-related protein 1 expression in APP/PS1 transgenic mice [0.03%]
BMP9通过促进APP/PS1转基因小鼠低密度脂蛋白受体相关蛋白1的表达来改善淀粉样病理损害
Lu Xiong,Zigao Wang
Lu Xiong
Alzheimer's disease (AD) is the most common cause of dementia worldwide. Our previous study revealed that bone morphogenetic protein 9 (BMP9) could ameliorate the amyloid pathology and cognitive impairments in a transgenic model of AD. Howe...
Primary somatosensory cortex sensitivity may increase upon completion of a motor task [0.03%]
完成一个运动任务可能会增加初级体感皮层的敏感性
Hideo Ohba,Kei Nakagawa,Koji Iida et al.
Hideo Ohba et al.
Objectives: The electroencephalogram and magnetic field primary somatosensory cortex (S1)-derived components are attenuated before and during motor tasks compared to the resting state, a phenomenon called gating; however,...
Association of plasma phosphor-tau181 with Aβ levels may vary by APOE ε4 status and sex among non-demented old adults [0.03%]
非痴呆老年人中tau蛋白磷酸化位点181与Aβ水平的关联可能因APOE ε4状态和性别而异
Yan Cai,Pan Fu,Xin Zhang;Alzheimer&#x;s Disease Neuroimaging Initiative
Yan Cai
Background: To evaluate the relationship between blood tau phosphorylated at threonine 181 (p-tau181) levels and β-amyloid (Aβ) levels, this study took the potential role of sex differences and apolipoprotein E (APOE)-...
Age-related changes in basal forebrain afferent activation in response to food paired stimuli [0.03%]
与年龄有关的基底前脑配对食物刺激的afferent激活的变化
Brandy Somera,Marla Frick,Jim R Fadel
Brandy Somera
The basal forebrain contains a phenotypically-diverse assembly of neurons, including those using acetylcholine as their neurotransmitter. This basal forebrain cholinergic system projects to the entire neocortical mantle as well as subcortic...
Associations between variants in levodopa metabolic pathway genes and levodopa-induced dyskinesia in Parkinson's disease [0.03%]
帕金森病左旋多巴诱导的异动症与左旋多巴代谢途径基因变异的关系
Jia-Hui Yan,Yi-Lun Ge,Pu-Zhi Wang et al.
Jia-Hui Yan et al.
Introduction: Levodopa-induced dyskinesia (LID) is a common motor complication in Parkinson's disease (PD). Several genes in the levodopa metabolic pathway, such as COMT, DRDx and MAO-B, were reported associated with LID....
Exosomes rich in Wnt5 improved circadian rhythm dysfunction via enhanced PPARγ activity in the 6-hydroxydopamine model of Parkinson's disease [0.03%]
富Wnt5外泌体通过增强PPARγ活性改善6-羟基多巴胺帕金森病模型中的昼夜节律功能障碍
Zongshan Li,Yongang Li,Xiaomin Xu et al.
Zongshan Li et al.
Sleep disorder is one of the most common non-motor symptoms in Parkinson's disease (PD) and even appear as early symptoms. Here we investigated the therapeutic potential of mesenchymal stem cell-derived exosomes (MSC-EXOs) on sleep disorder...
Effect of sevoflurane anesthesia to neonatal rat hippocampus by RNA-seq [0.03%]
RNA测序分析七氟烷致新生大鼠海马损伤的基因表达谱变化
Jinhua Feng,Xuesong Zhang,Menglu Jiang et al.
Jinhua Feng et al.
Background: Sevoflurane is an inhalational anesthetic for the induction and maintenance of general anesthesia in pediatric surgery. However, few studies have paid attention to the multiple organ toxicity and the mechanism...