The role of BDNF/PI3K/AKT/Nrf2 signaling in nicotine's protective effects against MPTP-induced Parkinson's disease [0.03%]
尼古丁通过BDNF/PI3K/AKT/Nrf2信号通路对MPTP诱导的帕金森病发挥保护作用及其机制研究
Nikoloz Zhgenti,Ekaterine Bakuradze,Otar Bibilashvili et al.
Nikoloz Zhgenti et al.
Parkinson's disease (PD) is characterized by progressive loss of dopaminergic neurons in the substantia nigra, where oxidative stress and apoptosis play central roles. Epidemiological evidence suggests that nicotine may exert neuroprotectiv...
Editorial: Laughing your… brain off. New insights on the adaptive meaning of humour [0.03%]
幽默的适应意义：捧腹大笑……裨益大脑？新的研究见解
Maria Elide Vanutelli,Mirella Manfredi
Maria Elide Vanutelli
Mitochondrial dysfunction and aging can be alleviated by modulating calcineurin and cardiolipin dynamics following stroke [0.03%]
线粒体功能障碍和衰老在中风后可通过调节钙调神经磷酸酶和脂质(cardiolipin)的动态变化得到缓解
Pallab Bhattacharya,Shailendra Saraf,Anirban Barik et al.
Pallab Bhattacharya et al.
The crucial influence of mitochondria in ischemic stroke pathophysiology presents many unexplored yet promising avenues for therapeutic strategies and clinical outcomes. Post-stroke mitochondrial dysfunction contributes to aggravated levels...
Regional differences in oxytocin and vasopressin 1a receptor functionality in mouse embryonic brain development [0.03%]
大鼠胚胎脑发育的区域差异及相关激素受体的功能研究
Elliot Sommer,Heather K Caldwell
Elliot Sommer
There is mounting evidence that the oxytocin (Oxt) and vasopressin (Avp) systems contribute to early brain development. Work from transgenic mouse models as well as pharmacological manipulation of the Oxt and Avp systems suggests that signa...
Increased reactive oxygen species in the spinal cord drive renal sympathetic vasomotor activity in Goldblatt hypertensive rats [0.03%]
金克高血压大鼠脊髓内活性氧增加驱动肾交感血管运动活动
Fernanda M Tagliapietra,Maycon I O Milanez,Edina da Luz Abreu et al.
Fernanda M Tagliapietra et al.
Increased production of reactive oxygen species (ROS) in brain regions contributes to the sympathetic vasomotor overactivity in Goldblatt hypertension (2K1C). Previously, studies reported that overexpression of spinal angiotensin II (Ang II...
Combined chronic oral methylphenidate and fluoxetine treatment increases CB1 receptor density in the somatosensory forelimb region [0.03%]
慢性口服哌甲酯和氟西汀联合治疗增加躯体感觉前肢区CB1受体密度
Abigail M Lantry,Huy Lu,Matt Marion et al.
Abigail M Lantry et al.
Methylphenidate (MP) is a psychostimulant commonly prescribed for attention deficit hyperactivity disorder (ADHD), and Fluoxetine (FLX) is a Serotonin Selective Reuptake Inhibitor (SSRI) commonly prescribed to treat depression and anxiety d...
Dexmedetomidine improves postoperative cognitive dysfunction via regulating Adrb2/Pkg: Dexmedetomidine against postoperative cognitive dysfunction [0.03%]
dexmedetomidine通过调节Adrb2/PKG治疗术后认知功能障碍
Cuirong Chen,Hong Han,Hongzhe Li et al.
Cuirong Chen et al.
Background: Postoperative cognitive dysfunction (POCD) refers to postoperative neurological complications in patients, thus affecting patients' normal daily life. ...
Hydrogen sulfide protects against hippocampal neuronal apoptosis in aged rats with postoperative cognitive dysfunction by promoting m6A methylation [0.03%]
氢硫化氢通过促进m6A甲基化对术后认知功能障碍年鼠海马神经元凋亡的保护作用
Bo Wang,YongPan Wen,Yonghong Tang et al.
Bo Wang et al.
Purpose: To explore the potential involvement of m6A methylation in the neuroprotective mechanism of H2S against hippocampus neuronal apoptosis in aged rats with POCD. ...
GABAergic disinhibition through the STING-dependent autophagic pathway in the dorsal horn underlies diabetic neuropathic pain pathogenesis [0.03%]
糖尿病性神经病理性疼痛发病机制背角γ-氨基丁酸(GABA)递质抑制功能失常的参与及作用路径研究
Ya-Jie Zhao,Hong-Zhen Bai,Yi-Na Wang et al.
Ya-Jie Zhao et al.
Our previous study demonstrated that STING/ATG5-mediated autophagy in the spinal dorsal horn contributes to diabetic neuropathic pain (DNP), although the underlying mechanisms remained unclear. In this study, we investigated how STING-drive...
Cannabidiol engages the peripheral endogenous opioid system to produce analgesia in neuropathic mice [0.03%]
大麻二酚通过作用于外周内源性阿片系统产生神经病理性疼痛镇痛作用
Douglas Lamounier de Almeida,Walace Cássio Pinto Barra,Renata Cristina Mendes Ferreira et al.
Douglas Lamounier de Almeida et al.
Cannabidiol (CBD) has been getting attention from the scientific community regarding its potential for the treatment of different conditions, such as epilepsy, anxiety, and pain. This potential can be useful in clinical practice as an alter...