Neuro-protection of swertisin against impairment induced by Aβ25-35 by acting on COX-2 to up-regulate 2-AG and suppressing neuroinflammation [0.03%]
通过作用于COX-2上调2-AG和抑制神经炎症来保护Aβ25-35诱导的神经损伤的sweritin机制研究
Jiang Wu,Lijin Zhou,Chao Lang
Jiang Wu
Ziziphi Spinosae Semen (Suan Zao Ren) is a traditional Chinese medicine with the functions of nourishing the heart and liver, calming the mind, and stopping sweating. Swertisin, one of the main active ingredients in Ziziphi Spinosae Semen, ...
Acute exposure to vaporized cannabidiol remodels coding and noncoding transcriptomes in the mouse striatum [0.03%]
急性吸入大麻二酚蒸汽会重塑小鼠纹状体的蛋白质和非编码转录组
Mi Ran Choi,Chaeeun Park,Jihun Kim et al.
Mi Ran Choi et al.
Cannabidiol (CBD) is increasingly consumed via vaping, but its acute molecular impact on the striatum, a critical hub for motor control and reward processing that is highly sensitive to cannabinoid modulation, remains poorly understood. Thi...
Site-Specific Regulation of Tau phosphorylation by MAPK pathways during HFS-Induced synaptic plasticity in the Rat hippocampus [0.03%]
海马高频刺激诱导的突触可塑性中MAPK通路对Tau磷酸化的位点特异性调节
Cem Süer,Burak Tan,Nurcan Dursun et al.
Cem Süer et al.
This study examined the role of MAPKs in Tau phosphorylation and synaptic plasticity at perforant pathway-dentate gyrus (PP-DG) synapses following high-frequency stimulation (HFS). In vivo experiments were conducted on adult male Wistar rat...
From stress to Alzheimer's: A circuit-based framework for prefrontal cognitive dysfunction [0.03%]
从压力到阿尔茨海默病：前额皮质认知功能障碍的电路框架理论
Jee Hyun Yi
Jee Hyun Yi
Impairments in working memory and cognitive flexibility are early and consistent features of both Alzheimer's disease (AD) and stress. These functions depend critically on prefrontal cortical (PFC) circuits, which are particularly vulnerabl...
Mini-review: "Hippocalcin: Molecular mechanisms and therapeutic potential in neuronal function" [0.03%]
简评： hippocalcin：分子机制及在神经元功能中的治疗潜力
Shin-Young Park
Shin-Young Park
Hippocalcin (HPCA), a neuronal Ca2+ sensor protein in the EF-hand superfamily, plays a key role in calcium signaling and neurological function in the central nervous system. This review highlights HPCA's structure-function relationships and...
Limitations of antibody-mediated neutrophil depletion in understanding the role of neutrophils following spinal cord injury in mice [0.03%]
抗体介导的中性粒细胞耗竭在理解小鼠脊髓损伤后中性粒细胞的作用方面的局限性
Rubing Zhou,Dawei Song,Miao Li et al.
Rubing Zhou et al.
The role of neutrophils in spinal cord injury (SCI) remains incompletely understood due to the absence of effective intervention strategies. Some studies employing antibody-mediated neutrophil depletion (ND) in vivo have yielded various con...
Ferulic acid possesses anxiolytic activity: evidence for the involvement of serotonergic and noradrenergic systems [0.03%]
丁香酸具有抗焦虑活性：涉及血清素和去甲肾上腺素系统的证据
Özlem P Çetiner,Hazal Eken,Feyza Alyu Altinok et al.
Özlem P Çetiner et al.
The current study aims to evaluate any potential anxiolytic effects and the action mechanisms of ferulic acid, a phenolic phytochemical compound, in mice. The anxiolytic activity of ferulic acid at the doses of 0.1, 1, 10, and 100 mg/kg, p....
Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures [0.03%]
胰岛素调节的氨基肽酶抑制剂C9可修复美沙酮破坏的原代细胞文化中的细胞活性
Frida Stam,Sara Bjurling,Erik Nylander et al.
Frida Stam et al.
Insulin-regulated aminopeptidase (IRAP) is emerging as a pharmaceutical target for treatment of neurotoxic- and neurodegenerative symptoms commonly seen in cognitive impairments. Ligands of IRAP, such as Angiotensin IV and similar analogues...
Differential expression of TRPV1 and TRPM8 in the mouse trigeminal ganglion and spinal dorsal root ganglion [0.03%]
小鼠三叉神经节和脊髓后根神经节中TRPV1和TRPM8的差异表达
Caifeng Shao,Jichao Wei,Hong-Yi Jia et al.
Caifeng Shao et al.
Transient receptor potential (TRP) ion channels, including the thermoreceptor TRP vanilloid 1 (TRPV1) and innocuous warm detector TRP melastatin 8 (TRPM8), are widely expressed on the primary sensory neurons of the trigeminal ganglion (TG) ...
Stable Traits, Adaptive Brains: links between Visual Homeostatic Plasticity and Personality [0.03%]
稳定的特征，适应性的大脑：视觉稳态可塑性和人格之间的联系
Marina Baroni,Valentina Cesari,Angelo Gemignani et al.
Marina Baroni et al.
This study explores the relationship between personality traits and visual homeostatic plasticity, a neural mechanism maintaining stable the brain activity. Actually, personality may influence neuroplasticity, the general brain ability to a...