Abscisic acid ameliorates cognitive deficits in an amyloid-β-induced mouse model of Alzheimer's disease associated with alterations in markers of neuroplasticity and neuroinflammation [0.03%]
脱落酸通过改变神经可塑性和神经炎症标志物改善淀粉样蛋白诱导的阿尔茨海默病小鼠模型的认知缺陷
Fatemeh Shahsavari,Mohammad Amin Rajizadeh,Zeynab Pirmoradi et al.
Fatemeh Shahsavari et al.
Abscisic acid (ABA, C15H20O4), a mammalian hormone, exhibits neuroprotective and anti-inflammatory properties. This study aimed to investigate the effects of ABA on the hippocampal-dependent processes: anxiety-, depression-like behaviors an...
Prolonged β-adrenergic stimulation reduces β2-adrenergic receptor levels and limits astrocytic responsiveness during early amyloid pathology [0.03%]
延长β肾上腺素能刺激会降低β2肾上腺素能受体水平并限制早期淀粉样病理过程中星形胶质细胞的反应性
Rupsa Roy Choudhury,Srishti Kushwaha,Smitha Karunakaran
Rupsa Roy Choudhury
Early Alzheimer's disease (AD) is associated with declining noradrenergic tone and early alterations in astrocytic regulation. β-adrenergic signaling links norepinephrine activity to extracellular signal-regulated kinase (ERK) activation a...
Formalin-induced pain preferentially activates orexin neurons in male mice [0.03%]
福尔马林诱导的小鼠疼痛会优先激活雄性小鼠的下丘脑分泌素神经元
Sosuke Fukasawa,Shinsaku Mukae,Arisa Matsuo et al.
Sosuke Fukasawa et al.
Sex differences are well-documented across many functions of the orexin system; however, whether such differences extend to pain processing has been examined far less thoroughly. Therefore, we investigated whether males and females differ i...
Metformin attenuates neurodegeneration in ICV-STZ-induced Alzheimer's model via antioxidant and anti-inflammatory mechanisms: implications for disease-modifying therapy [0.03%]
二甲双胍通过抗氧化和抗炎机制减轻脑室内注射链脲佐菌素诱导的阿尔茨海默病模型中的神经退行性病变：对改变疾病进程的治疗的意义
Mohamadkazem Darzi,Ravieh Golchoobian,Hossein Najafzadeh Varzi et al.
Mohamadkazem Darzi et al.
Alzheimer's disease (AD) is the leading cause of dementia, accounting for over 60% of cases in older adults. Growing evidence suggests that metformin, a first-line antidiabetic drug, may have neuroprotective properties. This study evaluated...
Brain creatine, estradiol and neurocognitive complaints in perimenopausal women: an exploratory cross-sectional study [0.03%]
绝经期妇女大脑磷Creatine、雌二醇与神经认知主诉之间的关系：一项探索性横断面研究
Sergej M Ostojic,Jelena Ostojic
Sergej M Ostojic
Background: Menopause and the perimenopausal transition involve profound hormonal and metabolic changes that may impair brain function. Beyond structural alterations, reduced cerebral bioenergetics could underlie the cogn...
Effect of ADP on cumulative TRPV1 desensitization to capsaicin in rat DRG neurons [0.03%]
ADP对大鼠DRG神经元累积性TRPV1脱敏的作用研究
Olena Petrushenko,Mariya Petrushenko,Elena Lukyanetz
Olena Petrushenko
Transient receptor potential vanilloid 1 (TRPV1) channels play a key role in nociception and undergo Ca2+-dependent desensitization, which is closely linked to cellular metabolic state. In nociceptive dorsal root ganglion (DRG) neurons, TRP...
Pharmacological inhibition of calcium channel modulates NF-κB-NLRP3 inflammasome axis and alters post-stroke innate immunity [0.03%]
钙通道的药理学抑制调节NF-κB-NLRP3炎性小体轴并改变中风后的先天免疫反应
Pallab Bhattacharya,Shailendra Saraf,Gautam Karmarkar et al.
Pallab Bhattacharya et al.
Ischemic stroke triggers a series of pathological processes where calcium overload and mitochondrial dysfunction are key mediators of neuronal damage. Mitochondria not only fail energetically under calcium excitotoxicity but also play a cru...
MiR-372-3p alleviates isoflurane-induced cognitive dysfunction by targeting STAT3 to mitigate neuroinflammation and oxidative stress [0.03%]
miR-372-3p通过靶向STAT3减轻异氟醚诱导的认知功能障碍及相关神经炎症和氧化应激损伤
Mingpei Zhao,Taifeng Li,Qingni Zhang et al.
Mingpei Zhao et al.
Objective: Isoflurane (ISO), a common anesthetic, can impair learning and memory, especially in the elderly. This study aims to determine whether miR-372-3p modulates neurocognitive dysfunction resulting from isoflurane a...
Dysregulation of mRNAs and hub genes in Parkinson's disease within post mortem substantia Nigra: using three methods differential expression genes analysis [0.03%]
死后黑质中帕金森病mRNA和中枢基因的失调：使用三种方法分析差异表达基因
Tun Lin Aung,Ye Win Aung,Khin Sandi Myint et al.
Tun Lin Aung et al.
This study employed an integrative bioinformatics approach to identify key molecular signatures in Parkinson's disease (PD) by analyzing substantia nigra transcriptomes from 22 PD patients and 22 healthy controls (HCs) across three Gene Exp...
The exposure to the air pollutant fine particulate matter (PM2.5) slightly enhances high-fat diet-induced anxiety-like behavior and impairs brain redox balance in female rats [0.03%]
空气污染物细颗粒物(PM2.5)暴露可轻微加重高脂饮食诱导的雌性大鼠焦虑样行为并扰乱大脑氧化还原平衡
Lílian Corrêa Costa-Beber,Eloísa Gabriela de Pelegrin Basso,Paula Taís Friske et al.
Lílian Corrêa Costa-Beber et al.
Introduction: Obesity is a major risk factor for mood disorders. Additionally, the pollutant fine particulate matter (PM2.5) has effects on central nervous system (CNS) that demand elucidation. ...