Genetic suppressions of CRMP2 phosphorylation ameliorate α-synuclein accumulation in an α-synucleinopathy mouse model [0.03%]
通过基因抑制CRMP2磷酸化缓解α-突触核蛋白病小鼠模型中的α-突触核蛋白聚集现象
Valeria Ayala Guevara,Yoshio Goshima,Toshio Ohshima
Valeria Ayala Guevara
α-synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of phosphorylated α-synuclein, forming the primary component of Lewy bodies. Current treatments can alleviate symptoms, however, there is stil...
CCDC181, a kinocilium-localization protein, is dispensable for hair bundle development and auditory perception [0.03%]
无CCDC181（一种纤毛定位蛋白）的耳蜗感觉毛细胞指状袋结构及听觉功能正常发声母系遗传性耳聋的原因
Chang Liu,Renat Nahornyi,Jinan Li et al.
Chang Liu et al.
Inner ear cochlear hair cells exhibit a highly specialized ciliary architecture that consists of a bundle of stereocilia responsible for mechanotransduction and, during development, a single kinocilium that governs hair bundle polarity. Whi...
Physical restraint induces conditioned place aversion and region-specific c-Fos activation in mice [0.03%]
物理强制束缚诱导小鼠形成条件性地方厌恶反应及区域特异性c-Fos活化
Ella Reinders,Maya Tondravi,Se Rin Lee et al.
Ella Reinders et al.
Linking environmental contexts with stressful experiences is critical for engaging adaptive responses necessary to avoid future threats. Yet, active context-dependent avoidance remains poorly understood. Here, we establish a restraint-induc...
Glycine removal from both glycinergic and glutamatergic synapses into astrocytic processes by glycine transporter 1 in the adult mouse spinal cord [0.03%]
成人小鼠脊髓中的甘氨酸转运蛋白1介导糖神经元和谷氨酸能突触的甘氨酸清除并转移至星形胶质细胞中
Chigusa Shimizu-Okabe,Ryuki Kobayashi,Toshihiro Konno et al.
Chigusa Shimizu-Okabe et al.
Glycine (Gly) and γ-aminobutyric acid (GABA) are inhibitory neurotransmitters in the spinal cord. Released Gly is removed by two Gly transporters (GlyTs): GlyT1 and GlyT2. We have previously demonstrated the localization of GlyT2, which re...
BAI attenuates depression by inhibiting P2X7R and NOX2: Insights from a pharmacological animal study [0.03%]
白藜芦醇通过抑制P2X7受体和NADPH氧化酶2缓解抑郁反应：药理学动物研究的启示
Baban S Thawkar,Nisarg S Sawant,Harsh Yadav
Baban S Thawkar
The present study demonstrated that baicalin produces antidepressant effects in rats exposed to chronic unpredictable mild stress. Following stress (ST) induction, behavioural evaluations such as the forced swim test, tail suspension test, ...
Prenatal alcohol exposure differently affects seizure susceptibility and severity depending on its mechanism of induction: role of excitatory synapses and parvalbumin-positive interneurons [0.03%]
孕期酒精暴露通过其诱导机制的不同方式影响癫痫易感性和严重程度：兴奋性突触和_parvalbumin_阳性中间神经元的作用
Luiza Dos Santos Heringer,Thamyres Bastos de Azevedo,Tais Martins Pereira Pontes et al.
Luiza Dos Santos Heringer et al.
Background: Prenatal alcohol exposure (PAE) leads to several neurological developmental deficits, including seizure predisposition. It is speculated that alcohol would interfere with the development of GABAergic neurons, ...
Luteolin attenuates tramadol-induced parkinsonism-like toxicity by modulating neurotransmitters, neuroinflammation, and GSK-3β signaling in rats [0.03%]
黄芩素通过调节神经递质、神经炎症和GSK-3β信号通路减轻tramadol诱导的大鼠类似帕金森毒性的发生
Nileshwar Kalia,Sourav Kumar Barik,Romanpreet Kaur et al.
Nileshwar Kalia et al.
Parkinsonism is a progressive neurodegenerative condition characterized by dopaminergic neuronal dysfunction, oxidative stress, neuroinflammation, neurotransmitter imbalance, and motor impairment. Chronic tramadol exposure has been reported...
Corrigendum to "Selective upregulation of fatty acid-binding protein 5 within the basolateral amygdala blunts stress-induced reinstatement of cocaine-seeking behavior in mice" [Neurosci. Lett. 878 (2026) 138558] [0.03%]
关于“选择性上调基底外侧杏仁核中的脂肪酸结合蛋白5减弱小鼠压力诱导的可卡因寻觅行为”的校正神经科学通讯[878(2026)138558]
Nicole Roeder,Aidan Powell,John Hamilton et al.
Nicole Roeder et al.
Published Erratum
Neuroscience letters. 2026 Jun 4:138646. DOI:10.1016/j.neulet.2026.138646 2026
Chronic low-dose oral methylglyoxal intake is associated with delayed circadian sleep timing and altered gut microbiota in mice [0.03%]
慢性低剂量甲基糖醛摄入与小鼠昼夜睡眠节律延迟和肠道菌群改变有关
Katsutaka Oishi,Natsumi Suzuki,Hitoshi Takei et al.
Katsutaka Oishi et al.
Reactive carbonyls including methylglyoxal (MGO) in foodstuffs irreversibly modify proteins and generate advanced glycation end products (AGEs) that are considered toxic. On the other hand, it has also been suggested that chronic MGO consum...
Lecanemab promotes Fc receptor-dependent cell-mediated internalization and degradation of aggregated amyloid-beta in vitro and ex vivo [0.03%]
莱卡内单抗促进Fc受体依赖的细胞介导的体内和体外聚集性淀粉样蛋白-β的内吞作用和降解
Nicolas Fritz,Malin Johannesson,Fredrik Eriksson et al.
Nicolas Fritz et al.
Plaque deposits containing aggregated amyloid beta peptide (Aβ) fibrils are present in brain regions affected by Alzheimer's disease (AD). Lecanemab is a therapeutic monoclonal antibody that binds preferentially to soluble Aβ assemblies k...