Involvement of substance P/NK1 receptor system in central sensitization in chronic pain [0.03%]
物质P/NK1受体系统在慢性疼痛中央敏化中的作用
Juan Chen,Yimin Lai,Wei Li
Juan Chen
Chronic pain has become a serious health issue, affecting more than 30% of people worldwide. One of the main mechanisms of chronic pain is central sensitization. It is well known that substance P (SP) and its receptor, Neurokinin 1 receptor...
TEMPOL alleviated tau pathology and cognitive deficits induced by P301S-tau [0.03%]
TEMPOL改善P301S-tau诱导的tau病理和认知缺陷
Xiao Li,Ruijuan Liu,Ye He et al.
Xiao Li et al.
Alzheimer's disease (AD) is the most frequent of neurodegenerative disease affecting elderly people. However, there is still no curative therapeutic strategies in clinical practice. Here, we studied whether TEMPOL as a free radical scavenge...
Involvement of the right inferior parietal lobule network in ipsilateral spatial attention [0.03%]
右半球顶下皮质网络在右侧空间注意中的作用
Marino Iwakiri,Yuhi Takeo,Takashi Ikeda et al.
Marino Iwakiri et al.
Unilateral spatial neglect (USN) significantly impairs mobility in patients following a stroke. The amount and quality of evidence supporting effective treatments for USN is still limited, primarily due to the unclear nature of its underlyi...
Piracetam reverses scopolamine-induced memory disorder in mice: an animal model using behavioral, oxidative, and cholinesterase biomarkers [0.03%]
匹莫奇特逆转天仙子胺致小鼠记忆紊乱：采用行为学、氧化及胆碱酯酶生物标志物的动物模型研究
Valfran da Silva Lima,Guilherme Luz Emerick,Valéria Dornelles Gindri Sinhorin et al.
Valfran da Silva Lima et al.
Memory impairment diseases have become a serious health problem worldwide. In this context, an animal model capable of recognizing substances with the ability to recover memory disorders would be welcome. Thus, the present work aims to eval...
Alcohol-induced neuropathy associated downregulation of Kv7 channels in primary nociceptors [0.03%]
酒精诱导的神经病理性疼痛与伤害性初级感觉神经元中Kv7通道表达下调的关系研究
Feyza Alyu Altinok,Ilhem Dallali,Ahmed Hasan et al.
Feyza Alyu Altinok et al.
Chronic alcohol consumption is a well-known risk factor for peripheral neuropathy, often presenting with thermal hyperalgesia and mechanical allodynia. While the involvement of dorsal root ganglia (DRG) neurons in alcohol-induced neuropathy...
Everolimus ameliorates cognitive deficits and synaptic dysfunction in mice with prefrontal cortical ADNP knockdown [0.03%]
埃维莫司可改善前额皮质ADNP敲低小鼠的认知缺陷和突触功能障碍
Yu Xiang,Zeyu Zhang,Yunrui Jiang et al.
Yu Xiang et al.
Activity-dependent neuroprotective protein (ADNP), a major risk gene for autism spectrum disorder (ASD) and intellectual disability (ID), is critical for brain development and cognition. Among its regulated processes, autophagy is notably a...
Constraint-induced movement therapy combined with Nogo-A downregulation enhances corticospinal tract remodeling and motor function in hemiplegic cerebral palsy mice [0.03%]
结合抑制Nogo-A表达的约束诱导运动疗法促进脑瘫模型鼠皮质脊髓通路重塑和功能恢复
Yuan Huang,Yunlan Xie,Liru Liu et al.
Yuan Huang et al.
Constraint-induced movement therapy (CIMT) enhances hand function in hemiplegic cerebral palsy (HCP) and stroke, partly by strengthening corticospinal tract (CST) projections, while down-regulated Nogo-A has been shown to facilitate neural ...
Reducing surgical complexity in SAH models: A modified approach for reliable early and long-term brain injury replication [0.03%]
减少SAH模型的手术复杂性：一种可靠的早期和长期脑损伤复制的改良方法
Xincan Zhao,Shuai Zhang,Shengming Jiang et al.
Xincan Zhao et al.
Among subarachnoid hemorrhage (SAH) models, the endovascular perforation method is widely used but limited by complex procedures and low efficiency. In this study, we developed a modified SAH model in male C57BL/6 mice by permanently ligati...
Environmental enrichment prevents depression-like behaviours induced by immune system activation in male mice [0.03%]
环境富养可防止激活的小鼠免疫系统引发的类似抑郁行为（英文：Environmental enrichment prevents depression-like behaviours induced by immune system activation in male mice）
Alexandre Kanashiro,Priscila Medeiros,Ana Carolina Medeiros et al.
Alexandre Kanashiro et al.
Depression is a debilitating psychiatric illness, and its etiology as well as resistance to current pharmacological treatments are increasingly associated with low-grade inflammation. Environmental enrichment (EE), a paradigm that combines ...
Artemisinin attenuates quinolinic acid-induced neurotoxicity by suppressing neuroinflammatory and apoptotic gene expression in rats [0.03%]
青蒿素通过抑制大鼠神经炎症和凋亡基因表达来缓解左旋喹啉酸诱导的神经毒性
Richmond Arthur,Uma Shanker,Manjinder Singh et al.
Richmond Arthur et al.
Neurotoxicity, characterised by the structural and functional disruption of the nervous system, remains a major contributor to the pathophysiology of neurodegenerative disorders. It is mostly caused by oxidative stress, excitotoxicity, mito...