Spatial summation of cold and warm detection: Evidence for increased precision when brisk stimuli are delivered over larger area [0.03%]
冷热检测的空间总和：当快速刺激作用在较大区域时精确度提高的证据
Arthur S Courtin,Aurore Delvaux,Arthur Dufour et al.
Arthur S Courtin et al.
Cold and warm stimuli delivered over a larger skin area tend to be more easily detected/elicit stronger sensations, a phenomenon referred to as spatial summation. The aim of the present study was to clarify how stimulation area affects ther...
Acute morphine injection persistently affects the electrophysiological characteristics of rat locus coeruleus neurons [0.03%]
急性吗啡注射持续影响大鼠蓝斑神经元的电生理特征
Fatemeh Farahani,Narges Pachenari,S Mohammad Ahmadi-Soleimani et al.
Fatemeh Farahani et al.
Administration of morphine is associated with critical complications in clinic which primarily includes the development of dependence and tolerance even following a single dose (acute) exposure. Behavioral and electrophysiological studies s...
Influence of traumatic brain injury on ipsilateral and contralateral cortical perfusion in mice [0.03%]
创伤性脑损伤对小鼠同侧和对侧皮质灌注的影响
Simon Meyer,Regina Hummel,Axel Neulen et al.
Simon Meyer et al.
Traumatic brain injury (TBI) is one of the most important causes of death in young adults. After brain injury cortical perfusion is impaired by cortical spreading depression, cerebral microvasospasm or microvascular thrombosis and contribut...
Parkinson's disease-associated 18 bp promoter variant of DJ-1 alters REST binding and regulates its expression [0.03%]
与帕金森病相关的DJ-1的18 bp启动子变异改变了REST结合并调节其表达
Prosenjit Pal,Shubhrajit Roy,Abhishek Chowdhury et al.
Prosenjit Pal et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder with a complex etiology. Presence of autosomal mutations in PARK7/DJ-1 gene has been associated with early-onset PD. Growing evidence has suggested that DJ-1 acts as a put...
Vitamin D and inflammatory cytokines association in mild cognitive impaired subjects [0.03%]
维生素D与轻度认知障碍者炎症细胞因子的关系研究
Abhai Kumar,Ashish Verma,Rameshwar Nath Chaurasia
Abhai Kumar
Background: Mild cognitive impairment (MCI) is a prodromal stage of Alzheimer's disease (AD). The association of low Vitamin D and chronic inflammation in the onset of cognitive decline in the elderly population has been ...
Inorganic arsenic alters the development of dopaminergic neurons but not serotonergic neurons and induces motor neuron development via Sonic hedgehog pathway in zebrafish [0.03%]
无机砷通过刺猬信号通路改变斑马鱼多巴胺能神经元的发育而不是血清素能神经元并且诱导运动神经元的发育
Jyotshna Kanungo,Nathan C Twaddle,Camila Silva et al.
Jyotshna Kanungo et al.
The mechanism of inorganic arsenic-induced neurotoxicity at the cellular level is not known. In zebrafish, teratological effects of inorganic arsenic have been shown at various concentrations. Here, we used similar concentrations of inorgan...
Comparative investigation of analgesic tolerance to taurine, sodium salicylate and morphine: Involvement of peripheral muscarinic receptors [0.03%]
牛磺酸，水杨酸钠和吗啡的镇痛耐受性之间的比较研究：周围毒覃碱受体的作用
Elham Akbari,Farimah Beheshti,Hassan Azhdari Zarmehri et al.
Elham Akbari et al.
Nowadays various analgesic medications are used for the management of acute and chronic pain. Among these opioid and non-steroidal anti-inflammatory drugs stand in the first line of therapy, however, prolonged administration of these substa...
Comparative Study
Neuroscience letters. 2023 Jan 31:795:137041. DOI:10.1016/j.neulet.2022.137041 2023
Neuronal melatonin type 1 receptor overexpression promotes M2 microglia polarization in cerebral ischemia/reperfusion-induced injury [0.03%]
神经元褪黑素1型受体过表达促进脑缺血/再灌注损伤中M2小胶质细胞极化
Yalikun Suofu,Abhishek Jauhari,Emilia S Nirmala et al.
Yalikun Suofu et al.
Microglial activation is readily detected following cerebral ischemia/reperfusion-induced injury. Activated microglia polarize into either classic pro-inflammatory M1 or protective M2 microglia following ischemia/reperfusion-induced injury....
Nitric oxide promotes cerebral ischemia/reperfusion injury through upregulating hypoxia-inducible factor1-α-associated inflammation and apoptosis in rats [0.03%]
一氧化氮通过增加与低氧诱导因子1-α相关的炎症和凋亡促进大鼠脑缺血/再灌注损伤
Nan Yang,Xueqi Yang,Yalan Fang et al.
Nan Yang et al.
Nitric oxide (NO) was one of the key factors to sustain hypoxia-inducible factor-1- α (HIF-1α) activation during hypoxia. However, the mechanism by which NO production promotes upregulation of HIF-1α to cause cerebral ischemia/reperfusio...
NLRP3 inflammasome inhibitor MCC950 reduces cerebral ischemia/reperfusion induced neuronal ferroptosis [0.03%]
NLRP3炎性小体抑制剂MCC950减少缺血/再灌注诱导的神经元铁死亡
Xiang Wu,Bo Wang,Yunfei Zhou et al.
Xiang Wu et al.
The role of nucleotide-binding oligomerization domainlike receptor pyrin domain containing 3 (NLRP3) inflammasome in cerebral ischemia-reperfusion (I/R) induced neuroinflammation and neuronal pyroptosis has been widely recognized. Latest st...