G protein-coupled receptor 17 promotes neuropathic pain in male mice by upregulating spinal NMDAR subunit expression [0.03%]
G蛋白偶联受体17通过上调脊髓NMDA受体亚单位表达促进雄性小鼠神经病理性疼痛
Biyun Li,Xueqin Xu,Qin Xiao et al.
Biyun Li et al.
Neuropathic pain is a prevalent and debilitating chronic condition for which current treatments often provide inadequate relief. This constitutes a significant unmet clinical need, highlighting the importance of identifying novel molecular ...
Differential neuroinflammatory trajectories in the hippocampus and prefrontal cortex after acute LPS administration [0.03%]
急性LPS给药后海马和前额叶皮层的神经炎症差异轨迹
Zhouli Yue,Mengyuan Li,Jiahui Wang et al.
Zhouli Yue et al.
Neuroinflammation is a key pathological feature of central nervous system disorders, yet its temporal and regional dynamics remain poorly defined. In this study, we systematically investigated neuroinflammatory responses and neuronal injury...
Enhanced antidepressant effects of fluoxetine combined with Quercetin: Studies in vitro and in vivo [0.03%]
氟西汀联合芸香素的增效抗抑郁作用：体内外研究
Ran Yang,Yifan Mao,Jialin Yang et al.
Ran Yang et al.
Objectives: This study aims to explore the enhanced antidepressant effects of the commonly used depressant fluoxetine combined with a dietary supplement quercetin, using both in vitro and in vivo models. ...
Comparative effects of antidepressants on cocaine-induced hyperthermia in rats: a preclinical study [0.03%]
抗抑郁药物对大鼠可卡因诱导的发热的影响：一项临床前研究
Tsuyoshi Okada,Seiji Obi,Manabu Takano et al.
Tsuyoshi Okada et al.
Purpose: Cocaine abuse is a major public health concern and is often associated with acute hyperthermia, which can be fatal and has limited pharmacological interventions for its management. Although antidepressants are fr...
Electroacupuncture at GV20 and GV24 acupoints ameliorates migraine by blocking NLRP3-mediated pyroptosis via inhibiting the Piezo1 channel [0.03%]
电针GV20和GV24穴通过抑制Piezo1通道阻断NLRP3介导的pyroptosis缓解偏头痛
Jianchang Luo,Liyao Feng,Wenbin Xu et al.
Jianchang Luo et al.
Migraine is a complex neuro-glio-vascular disorder, and electroacupuncture (EA) have been recommended as an alternative therapy for migraine. However, the mechanism of action of EA on GV20 (Baihui) and GV24 (Shenting) acupoints in treating ...
The role of childhood trauma in hippocampal subfield alterations in lithium-treated type I bipolar disorder and healthy controls: A subfield volumetry MRI study [0.03%]
锂治疗I型躁郁症和健康对照组儿童创伤在海马亚区变化中的作用：一项亚区体积MRI研究
Júnior Aparecido-de-Almeida,Marcio Gerhardt Soeiro-de-Souza
Júnior Aparecido-de-Almeida
Background: Type I bipolar disorder (BD) affects approximately 1% of the global population, and alterations in the morphology of the hippocampus, a cerebral region critical for memory and emotional regulation, may play an...
Prolonged exposure of cerebrocortical neurons to diazepam induces downregulation of surface α1-containing GABAA receptors and uncoupling of GABA/benzodiazepine site interactions through different mechanisms [0.03%]
地西泮对脑皮质神经元的长时间暴露通过不同的机制诱导表面α1-含甘氨酰苯二氮卓受体下调和抑制甘氨酰/苯二氮卓位点的相互作用
Leydi Carolina González Gómez,María Clara Gravielle
Leydi Carolina González Gómez
GABAA receptors play a crucial role in mediating fast inhibitory neurotransmission in the central nervous system. These receptors are targets of numerous pharmacological agents used clinically to control neuronal excitability in different n...
Recovery from cuprizone induced incontinence is not dependent upon remyelination [0.03%]
杯扎锌诱导的尿失禁恢复不依赖于再髓鞘化
Anirudhya Lahiri,Lucille E Papile,Zaenab Dhari et al.
Anirudhya Lahiri et al.
Dysfunction in bladder control (incontinence) is a significant comorbidity in multiple sclerosis that diminishes patients' quality of life and is a leading cause of hospitalization. Recent evidence indicates that CNS demyelination is suffic...
Chlorogenic acid exerts anti-inflammation and neuroprotective effect in pentylenetetrazole-induced epilepsy mouse model by regulating microglia polarization via Nrf2/HO-1 pathway [0.03%]
氯ogenic酸通过Nrf2/HO-1信号通路调节小胶质细胞极化对戊四唑诱导的癫痫小鼠模型发挥抗炎和神经保护作用
Yi Sun,Jiayu Wang,Aoyuan Zhang et al.
Yi Sun et al.
Chlorogenic acid (CGA) possesses diverse biological functions, including antioxidant, anti-inflammatory, and anti-apoptotic, both in vitro and in vivo. Recent studies have suggested that CGA also has neuroprotective effects. However, its po...
Antinociceptive role of IL-10/STAT3 signaling in trigeminal neuropathic pain male rat model through Pomc and β-endorphin [0.03%]
白细胞介素10/信号转导子和转录激活子3信号在三叉神经病理性痛雄性大鼠模型中的镇痛作用及促黑激素和β-内啡肽的作用机制研究
Lutfi Putra Perdana,Jaime Fabillar Jr,Dara Sari Arini et al.
Lutfi Putra Perdana et al.
Interleukin-10 (IL-10) is a cytokine that can exert an analgesic effect on trigeminal neuropathic pain (TNP). However, its precise mechanism remains unclear. In this study, we investigated the antinociceptive effects of recombinant IL-10 (r...