Safety and tolerability of switching to bictegravir/emtricitabine/tenofovir alafenamide versus continuing dolutegravir/lamivudine in people living with HIV with neuropsychiatric comorbidities: week 24 and 48 results from the Management of INSTI-associated Neuropsychiatric Disorders (MIND) clinical trial [0.03%]
Ignacio Perez-Valero,Diana Corona Mata,María Jose Crussells Canales et al.
Ignacio Perez-Valero et al.
Objectives: To evaluate if switching from dolutegravir/lamivudine (DTG/3TC) to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) improves neuropsychiatric tolerability in suppressed adults with stable neuropsy...
Revisiting Fluoroquinolone Prophylaxis in Hematological Malignancies and Hematopoietic Cell Transplantation: A Decade of Evidence and Gaps in Understanding the Impact of Gut Colonization with Fluoroquinolone-Resistant Enterobacterales [0.03%]
Hilal Abdessamad,Dania Abdallah,Rana Attieh et al.
Hilal Abdessamad et al.
Rising antimicrobial resistance necessitates reevaluation of fluoroquinolone (FQ) prophylaxis (FQP) in patients with hematologic malignancies undergoing intensive chemotherapy or hematopoietic cell transplantation (HCT). This narrative revi...
Comparative Efficacy and Safety of Antifungal Prophylactic Agents in Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Network Meta-Analysis [0.03%]
Xinyi Li,Ruonan Shao,Tingting Zhang et al.
Xinyi Li et al.
Background: Invasive fungal infections (IFIs) remain a major cause of morbidity and mortality among allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. There is still limited high-quality comparativ...
Risk factors and serum concentration thresholds associated with tigecycline-induced hepatotoxicity in critically ill patients [0.03%]
Mengxue Li,Jie He,Gaoqiu Dong et al.
Mengxue Li et al.
Background: Hepatotoxicity is a serious adverse effect associated with tigecycline therapy and may necessitate discontinuation of treatment. Optimal dosing strategies and predictive indicators are urgently needed to impro...
Efficacy and pharmacokinetics of a stepwise isolated phage cocktail against carbapenem-resistant Klebsiella pneumoniae in a murine pneumonia model [0.03%]
Xin Yin,Huan Luo,Yu Feng et al.
Xin Yin et al.
Phage therapy is a potential alternative to conventional antibiotic therapy to combat carbapenem-resistant Klebsiella pneumoniae (CRKP) infections. Studies based on pharmacokinetic of phage therapy are scarce, representing a major barrier t...
Population pharmacokinetics of total and free ceftriaxone in critically ill and non-critically ill hospitalised adult patients [0.03%]
Eko Setiawan,Alvaro Gonzalez,Saskia A Wölky et al.
Eko Setiawan et al.
Objective: To characterise the population pharmacokinetics of total and free ceftriaxone in critically ill and non-critically ill Indonesian patients, define optimised dosing regimens against common hospital pathogens imp...
Population pharmacokinetics of polymyxin B in critically ill patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infections [0.03%]
Puteri Juanita Zamri,Saskia A Wölky,Maria P Hernandez-Mitre et al.
Puteri Juanita Zamri et al.
The aims of this study were to characterise the population pharmacokinetics (PK) of polymyxin B and to identify rational dosing strategies for Malaysian hospitalised patients. Enrolled patients received a polymyxin B loading dose of 2.5 mg/...
Multidrug-Resistant Acinetobacter baumannii Pneumonia in Clinical Therapy: A Systematic Review and Network Meta-analysis on Effectiveness and Safety of Different Antibiotic Combination Regimens [0.03%]
Shao-Yuan Hao,Hau-Yu Lin,Po-I Yeh et al.
Shao-Yuan Hao et al.
Objective: To evaluate the effectiveness and safety of different antibiotic regimens for multidrug-resistant Acinetobacter baumannii (MDRAB) pneumonia using a network meta-analysis (NMA). ...