Efficacy and pharmacokinetics of a stepwise isolated phage cocktail against carbapenem-resistant Klebsiella pneumoniae in a murine pneumonia model [0.03%]
Xin Yin,Huan Luo,Yu Feng et al.
Xin Yin et al.
Phage therapy is a potential alternative to conventional antibiotic therapy to combat carbapenem-resistant Klebsiella pneumoniae (CRKP) infections. Studies based on pharmacokinetic of phage therapy are scarce, representing a major barrier t...
Population pharmacokinetics of total and free ceftriaxone in critically ill and non-critically ill hospitalised adult patients [0.03%]
Eko Setiawan,Alvaro Gonzalez,Saskia A Wölky et al.
Eko Setiawan et al.
Objective: To characterise the population pharmacokinetics of total and free ceftriaxone in critically ill and non-critically ill Indonesian patients, define optimised dosing regimens against common hospital pathogens imp...
Population pharmacokinetics of polymyxin B in critically ill patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infections [0.03%]
Puteri Juanita Zamri,Saskia A Wölky,Maria P Hernandez-Mitre et al.
Puteri Juanita Zamri et al.
The aims of this study were to characterise the population pharmacokinetics (PK) of polymyxin B and to identify rational dosing strategies for Malaysian hospitalised patients. Enrolled patients received a polymyxin B loading dose of 2.5 mg/...
Multidrug-Resistant Acinetobacter baumannii Pneumonia in Clinical Therapy: A Systematic Review and Network Meta-analysis on Effectiveness and Safety of Different Antibiotic Combination Regimens [0.03%]
Shao-Yuan Hao,Hau-Yu Lin,Po-I Yeh et al.
Shao-Yuan Hao et al.
Objective: To evaluate the effectiveness and safety of different antibiotic regimens for multidrug-resistant Acinetobacter baumannii (MDRAB) pneumonia using a network meta-analysis (NMA). ...
Comment on "ESBL-producing Escherichia coli bacteremic urinary tract infections: clinical and economic burden and antimicrobial stewardship opportunities in a retrospective cohort study" [0.03%]
Neeraj Singh,Monika Srivastav
Neeraj Singh
Comment on "Nanomedicine for phage therapy: Encapsulation strategies for enhanced antimicrobial efficacy" [0.03%]
Wenhao Wang,Ziyu Zhao,Zhengwei Huang
Wenhao Wang
Aggressive joint pharmacokinetic/pharmacodynamic target attainment of TDM-guided continuous infusion meropenem-vaborbactam monotherapy: a valuable strategy for maximizing the microbiological outcome of documented KPC-producing Enterobacterales infections? [0.03%]
Milo Gatti,Cecilia Bonazzetti,Benedetta Secci et al.
Milo Gatti et al.
Objective: To assess whether attaining an aggressive joint pharmacokinetic/pharmacodynamic (PK/PD) target of therapeutic drug monitoring (TDM)-guided continuous infusion (CI) meropenem-vaborbactam monotherapy may be a val...
Machine learning-based prediction of multi-level antimicrobial resistance in Klebsiella pneumoniae using whole-genome sequencing data [0.03%]
Xinmiao Jia,Jingjia Zhang,Jing Chen et al.
Xinmiao Jia et al.
Objectives: In this study, we developed an integrated approach for accurate and comprehensive prediction of antimicrobial resistance (AMR) using whole-genome sequencing (WGS) data. ...
A Multicenter, Randomized, Double-Blind, Imipenem/Cilastatin-Controlled Clinical Study of Cefiderocol for the Treatment of Complicated Urinary Tract Infections Caused by Gram-Negative Pathogens in Chinese Adults [0.03%]
Jinyi Yuan,Deyong Fan,Henglan Wu et al.
Jinyi Yuan et al.
Background: Cefiderocol, a siderophore cephalosporin, is approved for the treatment of complicated urinary tract infections (cUTIs) and other indications in the USA, Europe, and Japan. However, clinical data from China ar...
Model-Informed Cefepime Dosing in Pediatric Patients Receiving Continuous Renal Replacement Therapy [0.03%]
Ronaldo Morales Junior,Shannon Reinert,Emily Diseroad et al.
Ronaldo Morales Junior et al.
Critically ill children receiving β-lactam antibiotics while on continuous renal replacement therapy (CRRT) are at high risk of subtherapeutic or toxic antibiotic exposures due to patient-specific physiology and CRRT prescription parameter...