Fetal Response to Maternal Exposures of Environmental Chemicals: Utility of a Four-Cell Human Feto-Maternal Interface Organ-on-Chip [0.03%]
环境化学物质的胎盘屏障芯片模型：人类胎儿-母体界面四室芯片传感器对母亲接触的胎盘反应的研究价值
Haley L Moyer,SungJin Kim,Bowie P Lam et al.
Haley L Moyer et al.
Epidemiological studies suggest that maternal exposures to environmental pollutants may be linked to spontaneous preterm birth. Mechanistic studies are needed to provide support to these hypotheses; however, existing in vitro models do not ...
Targeting neuroblastoma with 3β,5α-tetrahydrocorticosterone: Activation of aryl hydrocarbon receptor inhibits tumor growth, metastasis, and stemness while promoting neural differentiation [0.03%]
靶向神经母细胞瘤使用3β，5α-四氢皮质酮：激活芳香烃受体抑制肿瘤生长、转移和干细胞特性并促进神经分化
Zhu-Qian Wen,Wen-Ming Hsu,Chien-Chun Chiou et al.
Zhu-Qian Wen et al.
Neuroblastoma (NB) is a highly malignant pediatric cancer that originates from the sympathoadrenal lineage of the neural crest. Recent studies have suggested the aryl hydrocarbon receptor (AHR) pathway as a promising therapeutic target for ...
Elucidating the binding mechanism between macluraxanthone and bovine serum albumin: multi-spectroscopic, computational, and biological insights [0.03%]
毛蕊黄素与牛血清白蛋白之间结合机制的阐明：多光谱、计算和生物角度的研究见解
Francis Ayimbila,Kamonrat Phopin,Ratchanok Pingaew et al.
Francis Ayimbila et al.
The binding nature of bioactive compounds with serum proteins, especially albumin, is noteworthy studied to achieve successful clinical drug development. Macluraxanthone (MCX), a bioactive xanthone, exhibits diverse pharmacological properti...
Atraric acid activates the FoxO3a/PINK1/Parkin signaling pathway to suppress chronic intermittent hypoxia-induced cardiac oxidative stress, inflammatory responses, and NLRP3 inflammasome activation [0.03%]
atraric酸通过激活FoxO3a/PINK1/Parkin信号通路来抑制慢性间歇低氧诱导的心脏氧化应激、炎症反应及NLRP3炎性小体活化
Mengxin Li,Wanqi Wu,Boran Hu et al.
Mengxin Li et al.
Obstructive sleep apnea syndrome (OSAS)-induced cardiac injury is closely associated with chronic intermittent hypoxia (CIH), but its molecular mechanisms and potential intervention strategies require further exploration. Atraric acid (AA),...
Reply to the Correspondence "Comments on Role of the interleukin-33 (IL-33)/ suppressor of tumorigenicity 2 (ST2) signaling in superoxide anion-triggered inflammation and pain behavior in mice" [0.03%]
关于信函“细胞因子IL-33/ST2信号转导在超氧阴离子致小鼠炎症和疼痛行为中作用”的回复
Sergio M Borghi,Thacyana T Carvalho,Mariana M Bertozzi et al.
Sergio M Borghi et al.
Targeting thioredoxin reductase 1 by Andrographolide contributes to inducing ROS-mediated apoptosis in human NSCLC cells [0.03%]
andrographolide通过靶向特异性抗氧化蛋白治疗非小细胞肺癌中的氧化应激诱导的凋亡作用研究
Jiabing Wang,Kaiwen Jin,Nan Jin et al.
Jiabing Wang et al.
Non-small cell lung cancer (NSCLC) is the most commonly diagnosed malignancy,causing a large number of deaths annually. Finding new drug candidates for treating advanced lung cancer is an urgent need. Andrographolide (Andro), a diterpenoid ...
Alsospinones A and B: Novel Flavonoid Modulators of CAT/GPX/TrxR with Integrated ADMET and Molecular Modeling [0.03%]
ALSPOINONES A 和 B：CAT/GPX/TrxR 新型黄酮调节剂的集成ADMET和分子建模研究
Syed Shams Ul Hassan,Wei Luo,Yan Ji et al.
Syed Shams Ul Hassan et al.
In the relentless pursuit of next-generation antioxidants, we have unveiled two unprecedented flavonoids-alsospinones A (1) and B (2) from the ancient fern Alsophila spinulosa, among which carbon skeleton of compound 2 was reported for the ...
Sublethal Effects of L-Tryptophan and Caffeine on Planarian Physiology: Insights into Serotonergic and Purinergic Disruption in Freshwater Ecosystems [0.03%]
L-色氨酸和咖啡因对变形虫生理的亚致死效应：关于淡水生态系统中血清素能和嘌呤能干扰的新见解
Elisa Martins Castro,Welligton Luciano Braguini
Elisa Martins Castro
L-tryptophan (Trp) and caffeine (Caf) are persistent neuroactive contaminants in aquatic systems. We investigated the sublethal toxicity of Trp and Caf to the freshwater planarian Girardia tigrina by assessing reproduction, regeneration, en...
The novel selective HDAC1 inhibitor ZJH-1 exhibits potent antitumor activity in castration-resistant prostate cancer, potentially involving HSP90AA1 [0.03%]
选择性HDAC1抑制剂ZJH-1在去势抵抗性前列腺癌中表现出强烈的抗肿瘤活性，可能涉及HSP90AA1
Yizhong Bao,Jitao Li,Aokang Zhang et al.
Yizhong Bao et al.
Histone deacetylase (HDAC) inhibitors are being explored as a therapeutic approach for prostate cancer (PCa), particularly castration-resistant variants with limited treatment options. In this study, we designed and synthesized ZJH-1, a nov...
Trans-Chalcone affects schistosomula and adult worms by impairing membrane integrity and attenuates the effects of Schistosoma mansoni-induced liver fibrosis [0.03%]
transc-h茋通过损害膜完整性影响裂殖体和成虫并减轻Schistosoma mansoni诱导的肝纤维化效应
Mariana Barbosa Detoni,Luryan Silvério Fidélis Ortiz,Amanda Caroliny Gomilde et al.
Mariana Barbosa Detoni et al.
Schistosomiasis is an acute and chronic parasitic disease caused by helminths of the genus Schistosoma. The current treatment, praziquantel, is ineffective against immature forms and during granuloma formation in chronic phase. Chalcones be...