Matrine-induced nephrotoxicity via GSK-3β/nrf2-mediated mitochondria-dependent apoptosis [0.03%]
通过GSK-3β/nrf2介导的线粒体依赖性凋亡诱导的苦参碱肾毒性
Tianyang Wang,Jian Zhang,Haokai Wei et al.
Tianyang Wang et al.
Introduction: Matrine (MT), an ingredient extracted from the Chinese herb Sophora flavescens, can result in nephrotoxicity because of long-term exposure. However, the underlying mechanism by which MT leads to kidney injur...
Scutebarbatine A induces ROS-mediated DNA damage and apoptosis in breast cancer cells by modulating MAPK and EGFR/Akt signaling pathway [0.03%]
穿心莲内酯通过调节MAPK和EGFR / AKT信号通路诱导ROS介导的DNA损伤和乳腺癌细胞凋亡
Xiao-Shan Hao,Pan-Pan Feng,Yun-Yun Zhang et al.
Xiao-Shan Hao et al.
Scutebarbatine A (SBT-A), a diterpenoid alkaloid, has exerted cytotoxicity on hepatocellular carcinoma cells in our previous works. Here, the antitumor activity of SBT-A in breast cancer cells and the underlying mechanism were explored. The...
Machine learning revealed ferroptosis features and ferroptosis-related gene-based immune microenvironment in lung adenocarcinoma [0.03%]
机器学习揭示了肺癌的铁死亡特征及基于基因的免疫微环境
Lianxiang Luo,Xinming Chen,Fangfang Huang
Lianxiang Luo
Ferroptosis has been identified as a novel type of programmed cell death that has a major effect on the development of lung adenocarcinoma. Nevertheless, there has yet to be a clear set of therapeutic targets based on ferroptosis. This stud...
l-carvone decreases breast cancer cells adhesion, migration, and invasion by suppressing FAK activation [0.03%]
L-薄荷脑通过抑制FAK活化来降低乳腺癌细胞的黏附、迁移和侵袭能力
Lucas Trevisan França de Lima,Fernando Augusto de Oliveira Ganzella,Gabriela Casani Cardoso et al.
Lucas Trevisan França de Lima et al.
Breast cancer is one of the most common types of cancer in the world and current therapeutic strategies present severe drawbacks. l-carvone (CRV), a monoterpene found in Mentha spicata (spearmint), has been reported to have potent anti-infl...
The triazole fungicide metconazole inhibits the homodimerization of human androgen receptors to suppress androgen-induced transcriptional activation [0.03%]
三唑类杀菌剂甲基康唑通过抑制人雄激素受体的二聚化来阻断雄激素诱导的转录活化作用
Da-Woon Jung,Da-Hyun Jeong,Uk-Jin Kim et al.
Da-Woon Jung et al.
We assessed the mechanism of human androgen receptor-mediated endocrine-disrupting effect by a triazole fungicide, metconazole in this study. The internationally validated stably transfected transactivation (STTA) in vitro assay, which was ...
Chelation therapy with 3,4,3-Li(1,2-HOPO) after pulmonary exposure to plutonium in rats [0.03%]
大鼠经肺暴露于钚后的3,4,3-Li(1,2-HOPO)螯合治疗
Olivier Grémy,Karine Devilliers,Laurent Miccoli
Olivier Grémy
Internal exposure to plutonium can occur through inhalation for the nuclear worker, but also for the public if the radionuclide was released into the atmosphere in the context of a nuclear accident or terrorist attack. DieThylenetriaminePen...
Bilirubin improves renal function by reversing the endoplasmic reticulum stress and inflammation in the kidneys of type 2 diabetic rats fed high-fat diet [0.03%]
胆红素通过逆转高脂饮食2型糖尿病大鼠肾脏内质网应激和炎症来改善肾功能
Mohammad Hassan Maleki,Elham Nadimi,Omid Vakili et al.
Mohammad Hassan Maleki et al.
Diabetic kidney disease (DKD), as a chronic diabetes-induced complication, is considered the most frequent leading cause of end-stage renal disease (ESRD). Regarding the observed protective effects of bilirubin, as a potential endogenous an...
(m-CF3-PhSe)2 benefits against anxiety-like phenotype associated with synaptic plasticity impairment and NMDAR-mediated neurotoxicity in young mice exposed to a lifestyle model [0.03%]
(m-CF3-PhSe)₂对生活方式模型暴露的小鼠突触可塑性损伤和NMDAR介导的神经毒性相关焦虑样表型有益
Sabrina G Müller,Natália S Jardim,Guilherme Lutz et al.
Sabrina G Müller et al.
Lifestyle habits including energy-dense foods and ethanol intake are associated with anxiety disorders. m-Trifluoromethyl-diphenyl diselenide [(m-CF3-PhSe)2] has been reported to modulate serotonergic and opioidergic systems and elicit an a...
Has PdCu@GO effect on oxidant/antioxidant balance? Using zebrafish embryos and larvae as a model [0.03%]
PdCu@GO对氧化/抗氧化平衡的影响吗？使用斑马鱼胚胎和幼体作为模型研究
Arzu Ucar,Aslı Çilingir Yeltekin,Mine Köktürk et al.
Arzu Ucar et al.
Industrial products containing PdCu@GO can gain access to the aquaculture environment, causing dangerous effects on living biota. In this study, the developmental toxicity of zebrafish treated with different concentrations (50, 100, 250, 50...
Galangin as an inflammatory response modulator: An updated overview and therapeutic potential [0.03%]
朴金作为炎症反应调节剂的最新概述和治疗潜力
Riya Thapa,Obaid Afzal,Abdulmalik Saleh Alfawaz Altamimi et al.
Riya Thapa et al.
Numerous chronic diseases, such as cancer, diabetes, rheumatoid arthritis, cardiovascular disease, and gastrointestinal disorders, all have an inflammation-based etiology. In cellular and animal models of inflammation, flavonols were used t...