Mitochondrial physiology and beyond: Mechanistic insights into kaempferol actions [0.03%]
线粒体生理学及其他：山柰酚作用的机制见解
Marcos Roberto de Oliveira
Marcos Roberto de Oliveira
Kaempferol (KAE), a dietary flavonoid, has emerged as a potent modulator of mitochondrial physiology, exerting multifaceted actions on bioenergetics, redox balance, mitochondrial dynamics, biogenesis, and quality control. Thus, the aim of t...
Investigating the interaction mechanism of five flavonoids and PD-L1 based on multi-spectroscopy and molecular dynamics [0.03%]
基于多光谱和分子动力学探究5种黄酮类化合物与PD-L1的作用机制
Yijie Cai,Yijun Tu,Hong Cheng et al.
Yijie Cai et al.
PD-L1 is an important protein overexpressed in various types of cancer. Flavonoids as common antioxidants have extensive bioactivities. In this study, the interaction mechanism and the structure-activity relationship between the five flavon...
CUDC-907 exerts an inhibitory effect on non-small cell lung cancer associated with induction of mitotic catastrophe and downregulation of YAP/TAZ signaling [0.03%]
CUDC-907通过诱导有丝分裂灾难和下调YAP / TAZ信号对非小细胞肺癌产生抑制作用
Yuan Liu,Xiao Qi,Xin-Peng Luo et al.
Yuan Liu et al.
Non-small cell lung cancer (NSCLC) is the most common histologic subtype of lung cancer associated with a relatively high mortality rate. CUDC-907, a dual-target inhibitor of histone deacetylase (HDAC) and phosphatidylinositol 3-kinase (PI3...
Integration of in vivo stress reporters with transcription profiling to define chemical mixtures mechanisms of toxicity, including trans-generational effects [0.03%]
体内压力报告与转录谱分析的结合用于定义化学混合物毒性机制（包括跨代效应）
Francisco Inesta-Vaquera,Wenduo Qi,Silviya Dimova-Vasileva et al.
Francisco Inesta-Vaquera et al.
Humans are exposed to mixtures of chemical pollutants from various environmental sources at all stages of life. Understanding how these compounds are causally linked to population health effects is challenging because of the ethical limitat...
Celecoxib blocks AKT/mTOR in AKT/YapS127A-driven intrahepatic cholangiocarcinoma, activating p21/p27 for cycle arrest and suppressing Mcl-1 for apoptosis [0.03%]
塞来昔布通过活化p21/p27诱导细胞周期阻滞和抑制Mcl-1诱导凋亡从而阻断AKT/mTOR信号通路以治疗由AKT/YapS127A驱动的肝内胆管癌
Xiangyun Tan,Yuan Yang,Junjie Hu et al.
Xiangyun Tan et al.
Intrahepatic cholangiocarcinoma (iCCA) is a malignant liver tumor with insidious onset, limited treatments, and poor prognosis. Recent studies show celecoxib exerts marked cytotoxic effects on cholangiocarcinoma cell lines, suggesting its p...
NR1I3 inhibits colorectal cancer growth by enhancing PCK1-mediated gluconeogenesis [0.03%]
NR1I3通过增强PCK1介导的糖异生抑制结直肠癌生长
Huanying Shi,Zimei Wu,Jiafeng Liu et al.
Huanying Shi et al.
There is increasing evidence that nuclear receptor subfamily 1 group I member 3 (NR1I3) plays a significant role in the progression of many malignancies. However, it is unclear whether NR1I3 suppresses colorectal cancer (CRC) growth or alte...
Involvement of Ductal Reaction in Di-(2-ethylhexyl)-Phthalate-Caused Hepatic Fibrosis: Molecular Mechanisms and Potential Intervention Strategies [0.03%]
邻苯二甲酸二辛酯致肝纤维化中心粒细胞反应的参与：分子机制及潜在干预策略
Xinru Du,Shu Zhang,Sha Liu et al.
Xinru Du et al.
Di-(2-ethylhexyl)-phthalate (DEHP) is a persistent environmental endocrine toxicant present in many products, and liver is the main target organ for DEHP metabolism. Long-term exposure to DEHP induces hepatic fibrosis, which is reversible i...
NIR fluorescent substrate-driven discovery of prolyl endopeptidase natural inhibitors and its inhibition of alpha-synuclein aggregation and promotion of autophagy [0.03%]
用于发现脯氨酰内肽酶天然抑制剂的近红外荧光底物及其抑制α-突触核蛋白聚集和促进自噬作用的研究
Jing Zhang,Kun-Jie Bian,Yi-Jing Wang et al.
Jing Zhang et al.
Prolyl endopeptidase (PREP) drives neurodegenerative diseases through dual mechanisms involving enzymatic activity and protein-protein interactions (PPIs), yet current inhibitors predominantly target single pathways Prolyl endopeptidase (PR...
Aluminum exposure disturbs epigenetic modification and organelle function during early embryo development [0.03%]
铝暴露可干扰早期胚胎发育中的表观遗传修饰和细胞器功能
Xiao-Ting Yu,Zhen-Hui Fu,Wen-Lin Pan et al.
Xiao-Ting Yu et al.
Aluminum is a lightweight and corrosion-resistant metal element that is widely used in industries, construction, food, and pharmaceuticals, and it can adversely affect multiple organ systems including the nervous system, skeletal system, re...
Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury [0.03%]
临床批准药物福莫特罗通过抑制脂质过氧化抑制铁死亡并减轻APAP致急性肝损伤
Lin-Song Teng,Zhen-Dong Ying,Xiao-Han Sun et al.
Lin-Song Teng et al.
Ferroptosis is an iron-dependent form of regulated cell death characterized by lethal lipid peroxidation and implicated in various human diseases. Despite intensive research, clinically applicable ferroptosis inhibitors remain unavailable. ...