Efficacy and Safety Outcomes of Different Plasma Clozapine and Norclozapine Levels in Schizophrenia Spectrum Disorder: A Dose-Response Meta-Analysis Exploring "critical" Levels [0.03%]
不同血浆氯氮平和nor氯氮平水平对精神分裂症谱系障碍疗效和安全性的影响：探索“临界”水平的剂量反应meta分析
Michele Fornaro,Chiara Di Lorenzo,Dan Siskind et al.
Michele Fornaro et al.
Background: A dose-response meta-analysis (DRMA) exploring serum/plasma clozapine and norclozapine concentrations in relation to efficacy and safety outcomes in schizophrenia spectrum disorders is warranted. ...
Psychotherapy training in psychiatry: a systematic review and narrative synthesis on the supervision experiences of early-career psychiatrists [0.03%]
精神病学中的心理治疗培训：早期职业精神病学家的督导经验的系统评价和叙述综合
Selin Tanyeri Kayahan,Mustafa Dinçer,Jesper Nørgaard Kjær et al.
Selin Tanyeri Kayahan et al.
Background: Supervision is a fundamental component of psychotherapy training, transforming theoretical knowledge into clinical skills through real-world practice. Psychotherapy training practices vary widely between count...
Effect of atenolol versus ivabradine on heart rate variability in patients of schizophrenia with clozapine-induced tachycardia: a randomized controlled trial [0.03%]
美托洛尔与伊伐布雷定对氯氮平所致心动过速的精神分裂症患者心率变异性影响的随机对照试验
Amit Bahmania,Manisha Kar,Tathagata Biswas et al.
Amit Bahmania et al.
Background: A third of schizophrenia cases are resistant to antipsychotics, where clozapine is the only FDA-approved medication. Clozapine use is often limited by intolerable adverse effects. Persistent tachycardia occurs...
Medication adherence following pharmacogenomic testing in patients with major depressive disorder [0.03%]
药基因组检测后主要抑郁障碍患者的用药依从性
Andria L Del Tredici,Holly L Johnson,W Brady DeHart et al.
Andria L Del Tredici et al.
Objective: Approximately 50% of patients with major depressive disorder (MDD) prematurely discontinue their antidepressant medication within 6 months, increasing risk of relapse. Pharmacogenomic (PGx) testing may improve ...
White matter microstructure mediates the link between rest-activity rhythm instability and mania symptoms in individuals at risk for bipolar disorder [0.03%]
休息活动节律不稳定通过白质微结构影响高危人群双相情感障碍躁狂症状
João Paulo Lima Santos,Lara Labardini,Lauren Keller et al.
João Paulo Lima Santos et al.
Adolescence and young adulthood are critical periods for the emergence of bipolar disorder (BD). Instability in sleep and rest-activity rhythms is associated with elevated risk for BD, yet little is known about the neural correlates of this...
Long after the split: The association between parental divorce and mental health in adults [0.03%]
离婚久矣：父母离异与成年人心理健康之间的关联
Mary Kate Schilke,Philip Baiden,Esme Fuller-Thomson
Mary Kate Schilke
Objective: The objective of the current study was to examine the association between adult mental illness and parental marital history (never married, continuously married, divorced during respondents' childhood). ...
Exercise-induced chronic adaptations and pro-inflammatory cytokine levels (IL-1β, IL-6, and TNF-α) in patients with depression: A systematic review and exploratory meta-analysis of randomized controlled trials [0.03%]
运动诱导的慢性适应和促炎细胞因子水平（IL-1β，IL-6和TNF-α）在抑郁患者中的变化：系统评价和探索性meta分析
Zhengyang Mei,Chenyi Cai,Hansen Li et al.
Zhengyang Mei et al.
Background: Depression is a leading cause of disability worldwide. Although exercise has been shown to alleviate depressive symptoms, potentially by affecting the body's inflammatory response, evidence in this area remain...
Evolving patterns of antipsychotic use and polypharmacy for schizophrenia in Hong Kong: a 21-year longitudinal study [0.03%]
香港21年纵向研究发现精神分裂症抗精神病药物使用模式及联用处方的演变规律
Eunice Kehui Deng,Vincent Kc Yan,Shek-Ming Leung et al.
Eunice Kehui Deng et al.
Background: Antipsychotics are the cornerstone of schizophrenia management, with antipsychotic polypharmacy commonly observed. This study aims to evaluate the trends of antipsychotic use and polypharmacy among individuals...
Glymphatic system dysfunction in chronic schizophrenia: A comparison between risperidone combined with clozapine and risperidone monotherapy [0.03%]
慢性精神分裂症患者甘淋巴系统功能障碍：利培酮合并氯丙嗪与单用利培酮的比较研究
Ying Li,Hangyu Li,Shiji Peng et al.
Ying Li et al.
Background: Despite documented brain alterations in chronic schizophrenia patients on risperidone or clozapine, differences in their effects on glymphatic function remain unclear. This study compared glymphatic function b...
The associations between sleep trouble, sleep duration, and peripheral blood inflammatory markers in adults: NHANES 2005-2020 [0.03%]
2005-2020年美国国家健康与营养调查（NHANES）中睡眠障碍、睡眠时长和外周血炎症标志物的关系研究
Wenjie Huang,Mengqiu Lan,Jiaoyan Liu et al.
Wenjie Huang et al.
Background: The primary objective of this study was to investigate the associations between sleep trouble, sleep duration, and peripheral blood composite inflammatory markers among U.S. adults. ...