From brain imaging phenotypes to vascular dementia subtypes: A comprehensive mendelian randomization study [0.03%]
从脑影像表型到血管性痴呆亚型：一项全面的孟德尔随机化研究
Congai Chen,Zehan Zhang,Qinglin Liu et al.
Congai Chen et al.
Background: Vascular dementia (VaD) is a heterogeneous disorder with distinct subtypes, each exhibiting unique neuropathological profiles. Although neuroimaging studies have identified some subtype-specific structural bra...
The effects of exercise modality and dose on improving executive function in stroke patients: A systematic review and Bayesian network dose-response meta-analysis [0.03%]
运动方式和剂量对卒中患者执行功能改善的影响：系统综述和贝叶斯网络剂量反应meta分析
Shaoqi Zheng,Qiuxue Pan,Liping Chen
Shaoqi Zheng
Objective: This Bayesian network meta-analysis examined exercise effects on executive function in stroke patients, exploring dose-response relationships and comparing the efficacy of different modalities to identify the o...
Integration of multiple omics reveals key targets and cellular mechanisms for intervention in sarcopenia [0.03%]
整合多组学揭示针对肌少症干预的关键靶点及细胞机制
Zhu Zhu,Wenji Wang,Qi Zhang et al.
Zhu Zhu et al.
Background: Sarcopenia, an age-related syndrome characterized by progressive loss of muscle mass, strength, and function, presents a significant global health burden with limited therapeutic interventions. This study inte...
Chronic loneliness and incident chronic lung diseases in two prospective cohorts [0.03%]
慢性孤独与两大前瞻性队列中慢性肺病的发病风险关系研究
Bo Yan,Yuechang Li,Haoyu Wu et al.
Bo Yan et al.
Background: Loneliness has been recognized as an independent predictor of incident chronic lung diseases. However, previous studies only focused on baseline loneliness status, not taking into consideration the changes in ...
Associations between intrinsic capacity transitions and incident cardiovascular disease among middle-aged and older adults [0.03%]
中老年人内在能力变化与心血管病发病的关系
Shuanglong Hou,Yi Pan,Jing Luo et al.
Shuanglong Hou et al.
Background: Emerging evidence suggests that intrinsic capacity (IC) impairments are potential predictors of cardiovascular disease (CVD), yet the impact of longitudinal IC transitions on CVD risk remain incompletely eluci...
Identifying multi-dimensional health clusters associated with high hospitalization burden among middle-aged and older adults in China: A 10-Year cohort study [0.03%]
一项为期10年的队列研究：识别中国中老年人群高住院负担的多维健康亚型
Jiaman Liao,Yaoting Su,Xueliang Huang et al.
Jiaman Liao et al.
Objective: To identify and characterize health subtypes among middle-aged and older adults in China, and test if individuals in high-burden subtypes experience greater hospitalization over time. ...
Benefit of home-based virtual reality aerobic exercise combined with resistance training for reversing sarcopenia and reducing depression in community-dwelling older adults with sarcopenia: a randomized control trial [0.03%]
家庭基于虚拟现实有氧运动结合阻力训练逆转社区老年人肌肉减少症及降低抑郁的积极作用：一项随机对照试验
Kornanong Yuenyongchaiwat,Chanakan Chitjamnogchai,Natsinee Sermsinsaithong et al.
Kornanong Yuenyongchaiwat et al.
Background: Sarcopenia is a growing concern owing to an aging global population. Older people with depression are at risk for sarcopenia and vice versa. Although physical exercise is key in preventing and managing sarcope...
Changes of multidimensional frailty among older adults during 2010-2023: A systematic review and cross-temporal meta-analysis [0.03%]
2010年至2023年老年人多维脆弱性变化的系统评价和跨时间Meta分析
Huanle Liu,Bin Chen,Xianying Lu et al.
Huanle Liu et al.
Objective: This study aimed to explore the changing trend of multidimensional frailty among the elderly from 2010 to 2023 and its relationship with social changes. ...
Single-cell transcriptomic analysis reveals the molecular alterations of endothelial cells during ageing [0.03%]
单细胞转录组分析揭示内皮细胞衰老过程中的分子改变
Yongle Sun,Yini Dai,Yehu Yin
Yongle Sun
Ageing of the vasculature is the fundamental cause for the development of cardiovascular diseases. Endothelial cells play an important role in ageing of the cardiovascular system, but the potential mechanisms of vascular ageing and the mole...
Effects of vitamin D intake alone on elderly body composition: A systematic review and meta-analysis of RCTs [0.03%]
单纯维生素D摄入对老年人体组成的影响：随机对照试验的系统评价和meta分析
Tomoyuki Matsuyama,Hiroshi Okada,Yuto Saijo et al.
Tomoyuki Matsuyama et al.
Background: This study investigated the effect of vitamin D on body composition in individuals aged 60 years and older. Methods: PubMed...