Effects of multi-component interventions on the lifestyle in pre-frail or frail older adults: A systematic review and meta-analysis [0.03%]
多成分干预对前衰弱或衰弱老年人生活方式影响的系统评价和meta分析
Xinyu Wan,Xuehan Ma,Gengxin Yao et al.
Xinyu Wan et al.
Background: Frailty is defined as a biological syndrome characterized by a decreased reserve and resistance to stressors. Frailty is closely related to lifestyle, and improving lifestyle can effectively reduce the inciden...
Associations of frailty and its changes with the risks of depressive symptoms: A multi-cohort study [0.03%]
脆弱性与抑郁症症状风险的关系：一项多队列研究
Zhuling Yu,Yanbo Teng,Le Peng
Zhuling Yu
Background: Frailty is a dynamic condition that may affect mental health. This study aimed to investigate the associations of frailty and its changes with the risks of depressive symptoms across multiple regions in aging ...
The association between intrinsic capacity and functional ability in older adults - exploring the role of the physical environment [0.03%]
内在能力与老年人功能能力之间的关系-探索物理环境的作用
Jaro Govaerts,Laura A Schaap,Erik J Timmermans et al.
Jaro Govaerts et al.
Background: Ageing in place has been promoted in the Netherlands to encourage optimal functional ability (FA) and independent living among older adults. FA is likely dependent on intrinsic capacity (IC), a composite measu...
Predictive validity of senior volunteer-led frailty check-up results for disability and mortality among community-dwelling older adults: a cohort study [0.03%]
老年人能力筛查结果对社区老年人失能和死亡的预测效力：群组队列研究
Tomoki Tanaka,Weida Lyu,Yasuyo Yoshizawa et al.
Tomoki Tanaka et al.
A frailty checkup program (FC), a community-based frailty prevention initiative led by trained senior volunteers (FC supporters), has been implemented in over 100 municipalities in Japan. Participants create individual result sheets by mark...
Balancing palliative care needs and medication appropriateness: Initiation and reinitiation of medications at the end of life [0.03%]
姑息治疗需求与药物合理性：生命末期的用药启动和重新启动
Degefaye Zelalem Anlay,Kristel Paque,Astrid D H Brys et al.
Degefaye Zelalem Anlay et al.
Background: Medications deemed inappropriate and discontinued in the earlier stages of life-limiting disease may become relevant in palliative care context at the end of life. This study aims to determine the incidence of...
U-shaped association between post-stroke cognitive impairment and high-density lipoprotein cholesterol at the acute period of stroke [0.03%]
急性卒中时期载脂蛋白胆固醇与卒中后认知障碍的U型关联
Yue Wang,Qing Wang,Ling Tong et al.
Yue Wang et al.
Post-stroke cognitive impairment (PSCI) imposes a significant economic and social burden on patients and their families. High-density lipoprotein cholesterol (HDL-C) is reported to have protective effects on cognitive function in older adul...
Understanding barriers and facilitators to oral health interventions in community-dwelling older adults with cognitive impairment: A scoping review [0.03%]
理解社区居住的认知障碍老年人口腔健康干预的障碍和促进因素：一项综述研究
Yaqi Huang,Youran Liu,Chun Man Wong et al.
Yaqi Huang et al.
Background: Older adults with cognitive impairment face significant challenges in maintaining oral health while the barriers and facilitators for implementing communitybased oral health interventions are uncertain. ...
A novel HDAC1-specific inhibitor prevents estrogen deficiency-induced osteoporosis in mice by inhibiting osteoclast function [0.03%]
一种新型组蛋白去乙酰酶1特异性抑制剂通过抑制破骨细胞功能防治雌激素缺乏型绝经后骨质疏松症小鼠疾病恶化
Hang Yuan,Yizhong Bao,Li Li et al.
Hang Yuan et al.
Postmenopausal osteoporosis (PMOP) features reduced bone mass and deteriorated bone microstructure, increasing fracture risk. Estrogen deficiency-induced osteoclast overactivation is a primary driver. OCP-001, a novel highly selective HDAC1...
An interactive dynamic online nomogram for predicting the heterogeneous trajectories of intrinsic capacity among older adults [0.03%]
一种用于预测老年人内在能力异质性轨迹的交互式动态在线诺模图
Wenfeng Xu,Liyuan Tian,Hongliang Dai
Wenfeng Xu
Background: With increasing age, intrinsic capacity (IC) in older adults tends to decline. Currently, no studies have used nomograms to predict high-risk factors for IC decline based on its heterogeneous trajectories. ...
Global and regional drivers of chronic kidney disease burden in older adults: The dominant role of high fasting plasma glucose and the rise of obesity in China [0.03%]
老年慢性肾脏病负担的全球及区域影响因素：中国高空腹血糖的影响和肥胖的上升不容忽视
Jie Gu,Huaizhou You
Jie Gu
Background: Chronic kidney disease (CKD) is a major public health challenge for older adults, increasing global healthcare burdens. However, comprehensive global analyses of long-term trends and regional disparities in CK...