Cell-type-specific genetic associations in Lewy body dementia identified using single-cell eQTL-based Mendelian randomization [0.03%]
基于单细胞eQTL的孟德尔随机化在路易体痴呆中鉴定出特定类型的遗传关联
Yu-Liang Gao,Qiu-Han Xu,Hong Ye et al.
Yu-Liang Gao et al.
Background: Lewy body dementia (LBD) is a complex neurodegenerative disorder marked by α-synuclein aggregation and dual impairment of cognitive and motor function.While genome-wide association studies have identified ris...
Social and lifestyle factors associated with the risk of developing multimorbidity in middle-aged and older adults [0.03%]
中老年期多重慢性疾病的危险因素及其社会和生活方式的影响研究
Damián González-Beltrán,Humberto Yévenes-Briones,Aitana Vázquez-Fernández et al.
Damián González-Beltrán et al.
Background: Previous studies have identified several determinants of multimorbidity, but social factors remain unclear. Therefore, we aimed to explore the association between social and lifestyle factors and the risk of d...
Liang-Kung Chen
Liang-Kung Chen
Effects of 16-week aerobic exercise and whole-body vibration on myokines and neurocognitive indices in postmenopausal women: A randomized control study [0.03%]
有氧运动和全身振动对绝经后女性肌因子及神经认知指标影响的随机对照研究
Chia-Liang Tsai,Cheng-Liang Chang
Chia-Liang Tsai
This study aimed to investigate whether aerobic exercise (AE) and AE combined with whole-body vibration (AE+WBV) exert distinct effects on neurocognitive outcomes and circulating myokines, and to further explore the potential molecular mech...
Prevalence and predictors of sarcopenia in hospitalised adults aged 86 and older [0.03%]
老年住院患者肌少症的患病率和预测因素
Thomas Roberts,Thomas Fraccalini;colleagues
Thomas Roberts
Multi-trajectories of intrinsic capacity and their impact on incident disability in community-dwelling older adults in Japan [0.03%]
日本社区老年人内在能力多轨迹及其对新发残疾的影响
Shu Zhang,Chikako Tange,Hiroshi Shimokata et al.
Shu Zhang et al.
Background: The World Health Organization's intrinsic capacity (IC) framework has shifted focus from functional deficits to preserving abilities in ageing. However, the trajectories of IC and their impact on disability re...
Missing teeth and missing years: Oral health and survival in a Brazilian aging cohort [0.03%]
缺牙与缺年：巴西一项关于口腔健康和寿命的队列研究
Marco A Peres,Huihua Li,Karen G Peres et al.
Marco A Peres et al.
Oral health is key but often overlooked in healthy aging. Tooth loss and poor oral function can impair nutrition, communication, and well-being, yet evidence from low- and middle-income countries (LMICs) on their impact on longevity is limi...
Ten-year longitudinal effects of physical activity and apolipoprotein E ..4 genotype on precuneus atrophy in Japanese older adults [0.03%]
身体活动和载脂蛋白E基因型对日本老年人十年纵向前扣带回萎缩的影响研究
Atsumu Yuki,Yukiko Nishita,Akinori Nakamura et al.
Atsumu Yuki et al.
Background: The apolipoprotein E ε4 (APOE ε4) allele, a major genetic risk factor for Alzheimer's disease, is associated with early atrophy in the precuneus and posterior cingulate cortex. Whether physical activity can ...
Associations of adverse childhood experiences and sleep in adulthood and older age: A nationwide cohort study [0.03%]
童年不良经历与成年期和老年期睡眠障碍的关联——一项全国队列研究
Qiuyu Chen,Jiaqi Zhao,Xin Zhang et al.
Qiuyu Chen et al.
Background: Longitudinal evidence on the association between adverse childhood experiences (ACEs) and sleep in Chinese middle-aged and older adults is limited. ...
Pei-Chun Ko,Barbara Barbosa Neves,Rosanne Freak-Poli
Pei-Chun Ko
Spouses and children are central to caregiving and social support in later life. Yet, changing family relationships, and the rising trend of kinlessness - defined as lacking a partner and living children - can impact health in later life. H...