Enhanced affinity for lipophilic dyes in neurons damaged by ischemia or hypoxia [0.03%]
缺血或低氧损伤的神经元对亲脂性染料的亲和力增强
Yan-Chao Li,Bai-Hong Tan,Yan-Feng Zhang
Yan-Chao Li
Background: Techniques for detecting neuronal death not only facilitate tracking disease progression but also serve as essential tools for validating experimental models and evaluating neuroprotective interventions. Howev...
Advancing temporal dynamics in spatial Random Field Theory: A framework for fMRI signal detection with simulation studies and task-based fMRI application [0.03%]
基于任务的fMRI数据在时空随机域理论信号检测框架下的应用与仿真研究
Theophilus B K Acquah,Khalil Shafie
Theophilus B K Acquah
Background: Functional magnetic resonance imaging (fMRI) data exhibit complex spatial and temporal dependencies, yet most statistical approaches rely on static or temporally independent models, limiting sensitivity to dyn...
A functional deep cervical lymphovenous anastomosis model in APP/PS1 mice augmenting cerebral lymphatic drainage [0.03%]
APP/PS1小鼠功能性深颈部淋巴静脉吻合模型促进脑淋巴引流
Yifan Liu,Yunzhao Jiang,Zhenhao Zhao et al.
Yifan Liu et al.
Background: Deep cervical lymphatics constitute the final pathway for cerebral lymphatic drainage into the circulatory system. Dysfunction in this pathway inevitably impairs the clearance of cerebral metabolic waste. Rece...
Streamlined correlative live-confocal and SBF-SEM imaging reveals early inflammatory dendritic changes induced by microglia [0.03%]
streamlined联用活体共聚焦和SBF-SEM成像技术揭示小胶质细胞诱导的早期炎症性树突改变
Christoph Jähnig,Nikola Tomov,Adolfo Odriozola et al.
Christoph Jähnig et al.
Background: As cells that constantly survey their environment, microglia rely on contact with neurons, non-neuronal cells and extracellular substances. The diversity of microglial receptors allows them to elicit either lo...
Chloral Hydrate versus Isofluorane anesthesia and their differential impact on the midbrain system [0.03%]
氯化水合物和异氟尔烷麻醉对中脑系统的影响差异
A Hamza,A A Grace
A Hamza
Background: Isoflurane (ISO) has become one of the most commonly used anesthetics for animal surgery, has largely replaced chloral hydrate (CH). Despite this shift, the physiological consequences of these anesthetics on d...
Behavioral dynamics of different stages of sexual motivation in male and female rats [0.03%]
雌雄大鼠性动机不同阶段的行为动力学变化规律研究
John C Oyem,Patty T Huijgens,Julissa Mendoza et al.
John C Oyem et al.
Background: Sexual motivation is a complex concept involving both the initial drive to begin mating and the motivation to sustain copulation. Disruptions in sexual motivation are often observed in psychiatric disorders. T...
Segregated encoding of auditory and visual information in EEG oscillations [0.03%]
听觉和视觉信息在脑电振荡中的分离编码
Xiaohan Bao,Ying Huang,Stephen G Lomber
Xiaohan Bao
Background: Extracting unisensory information from multisensory inputs is a fundamental function of a sensory system. However, little is known on how modality-specific stimulus information is encoded during multisensory p...
Home-cage monitoring methods reveal age- and strain-related differences in motor, thermal, and cognitive functions in male mice of two inbred strains [0.03%]
基于笼养的监测方法揭示了两个近交系小鼠在年龄和品系相关的运动、热应激及认知功能方面的差异
Mahvish Faisal,Konstantin Radyushkin,Jan Baumgart
Mahvish Faisal
Background: Aging is associated with cognitive decline and behavioral alterations linked to neurobiological changes. Rodent models are crucial for investigating age-related variations in cognitive flexibility, anxiety, an...
The anoxia escape test as a novel and sensitive protocol to assess despair-like behavior in zebrafish [0.03%]
一种新型且敏感的小鱼绝望行为评估方法——缺氧逃避实验
Francisco Carlos da Silva Junior,Igo Padilha de Sousa,João Paulo Medeiros Mamede et al.
Francisco Carlos da Silva Junior et al.
Background: Behavioral despair-like states are commonly modeled in rodents using inescapable stressors that suppress active coping, yet comparable paradigms for zebrafish remain limited. ...
Location and strength reliability of superficial target toward transcranial magnetic stimulation guided with effective functional connectivity [0.03%]
有效功能连接引导下经颅磁刺激浅层靶点的位置及强度可靠性研究
Bo-Han Zang,Xiao Chen,Yi-Bing Wang et al.
Bo-Han Zang et al.
Background: Individualized transcranial magnetic stimulation (TMS) can be optimized using functional connectivity (FC). Compared to undirected FC, effective connectivity (eFC) reveals causal relationships between brain re...