Dual-frequency spinal cord stimulation increases responder rates for treatment of neuropathic pain [0.03%]
双频脊髓刺激可提高神经病理性疼痛的治疗反应率
Katherine M Lambert,Tianhe Zhang,John E Gilbert et al.
Katherine M Lambert et al.
Spinal cord stimulation (SCS) is an established treatment for chronic pain. However, there is a clear opportunity for improvement as only approximately 60% of patients report a 50% or greater reduction in pain. In this study, we propose a n...
Distinct neuroinflammatory effects of individual chemotherapeutics shape chemotherapy-induced peripheral neuropathy in a novel mouse model of CVAD combination regimen [0.03%]
一种新型CVAD联合方案小鼠模型中的个体化学治疗药物产生不同的神经炎症效应从而塑造由化疗引起的外周神经病
Hana Starobova,Nicolette Tay,Nikhil Inturi Nageshwar et al.
Hana Starobova et al.
Chemotherapy-induced peripheral neuropathy is a common, dose-limiting toxicity of cancer treatment for which no disease-modifying therapies exist. Vincristine-induced neuropathy has been linked to neuroimmune activation and interleukin-1 (I...
What a pain! The elusive management of an individual patient with SCN9A sodium channelopathy in the perioperative setting [0.03%]
手术围术期SCN9A钠离子通道病患者的管理:真是令人头疼的问题！
Michael Wadle,Bianca Szafarowicz,Sydney Nykiel-Bailey et al.
Michael Wadle et al.
Mutations in the SCN9A gene, which encodes the sodium voltage-gated channel alpha subunit 9 on chromosome 2 (Nav1.7), are extremely rare and play a crucial role in pain signaling. Depending on the type of mutation, the clinical presentation...
Neuropilin-1 mediates nerve growth factor signaling of oral cancer pain [0.03%]
神经纤毛蛋白-1介导口腔癌痛的神经生长因子信号转导
Maria Fernanda Pessano Fialho,Elisa Damo,Raquel Tonello et al.
Maria Fernanda Pessano Fialho et al.
Oral cancer is one of the most painful malignancies, with pain driven primarily by algogenic mediators in the tumor microenvironment, including nerve growth factor (NGF). Although NGF monoclonal antibodies alleviate cancer pain in patients,...
Reframing nociplastic pain research and treatment using post-traumatic stress disorder-inspired conceptual models [0.03%]
借鉴 PTSD 的概念模型重塑痛觉异常的研究与治疗
Alexia Coulombe-Leveque,Robert P Bonin,Guillaume Léonard
Alexia Coulombe-Leveque
Pain and fear are aversive alarm signals that serve adaptive protective functions. Pathologically disproportionate fear or pain responses can lead to conditions such as post-traumatic stress disorder (PTSD) or chronic pain. Although they ar...
Sex differences in adolescent chronic pain outcomes after spinal fusion: role of coping strategies [0.03%]
应对策略在青少年脊柱融合术后慢性疼痛结果性别差异中的作用
Rui Li,Guillermo Ceniza-Bordallo,Bethany D Pester et al.
Rui Li et al.
Sex differences in postsurgical pain are poorly understood in adolescence, a critical period for chronic pain development. The aims of this analysis were to examine sex differences in chronic pain outcomes 6 months after spinal fusion and t...
Inhibition of heat shock protein 90 in the mouse spinal cord enhances opioid antinociception through upregulation of PKCβ in CGRP neurons [0.03%]
抑制小鼠脊髓中的热休克蛋白90可上调PKCβ/CGRP神经元的表达并增强阿片类药物镇痛作用
Jessica L Bowden,Jerry E Carr,Katherin A Gabriel et al.
Jessica L Bowden et al.
Decades of research have uncovered the complex signaling network downstream of the opioid receptors and suggested how this signaling could be modulated to improve opioid therapy. In our study, we have found that heat shock protein 90 (Hsp90...
Brief cognitive behavioral therapy for chronic pain rapidly improves pain interference: a randomized controlled trial [0.03%]
简短的认知行为疗法可快速改善慢性疼痛患者的病情干扰：一项随机对照试验
Gregory P Beehler,Paul R King,Jennifer S Funderburk et al.
Gregory P Beehler et al.
Abbreviated psychotherapies for chronic pain improve access to care by reducing length of treatment and reaching patients outside of chronic pain clinics, such as primary care. However, the evidence for these approaches is limited. We condu...
Lanthionine synthetase C-like protein 1 (LanCL1): a therapeutic target for neuropathic pain [0.03%]
lancl1（lancl1）：治疗神经性疼痛的靶点
David C Spanswick,Haifeng Wei,Fei-Yue Zhao et al.
David C Spanswick et al.
Since the discovery of the mammalian lanthionine synthetase C-like (LanCL) proteins, there has been considerable interest in identifying their functions. Using LAT8881, a novel peptide ligand for LanCL1, we confirm a key role for LanCL1 in ...
A prospective diary study of chronic pain-related intrusive mental imagery: "trolls climbing up my spine with ice axes" and other vivid images [0.03%]
前瞻性的日记研究：慢性疼痛相关的闯入性心理意象——“ trolls用冰斧沿着我的脊椎往上爬”和其他生动的意象
Luzia Grabherr,Daniel Ferreiro Couto,Carlo Delli Noci et al.
Luzia Grabherr et al.
People with chronic pain can experience intrusive mental images (IMI) related to pain, that is, cognitions in the form of sensory-like experiences without actual sensory input. Previous retrospective studies suggested that such images are p...