One in seven has severe pain: a point-prevalence study of hospitalised patients across Africa [0.03%]
七分之一的住院病人遭受严重疼痛：非洲住院患者的患病率调查研究
Gillian J Bedwell,Romy Parker,Victoria J Madden et al.
Gillian J Bedwell et al.
Acute pain in hospitalised patients is common, yet African data are scarce. We conducted a prospective point-prevalence study of hospitalised adult patients across Africa to determine acute pain prevalence and severity and investigate assoc...
Emerging clinical pain research in low- and middle-income settings: towards a person-centred approach [0.03%]
低收入和中等收入国家的临床疼痛研究新趋势：以个人为中心的方法
René Tanious,Victoria J Madden,Saurab Sharma et al.
René Tanious et al.
Group-based randomized controlled trials (RCTs) in clinical pain research in low- and middle-income settings (LMIS) face distinct challenges, including resource-related limitations and contextual barriers. In addition, evidence garnered thr...
Jakob Poehlmann,Tibor M Szikszay,Luisa Luebke et al.
Jakob Poehlmann et al.
Temporal contrast enhancement (TCE), also termed offset analgesia, describes a temporal filtering mechanism, whereby a small decrease in stimulus intensity produces a disproportionately large reduction in perceived pain. Although TCE is con...
A glutamatergic S1-VPL-S1 corticothalamocortical loop amplifies mechanical hypersensitivity in neuropathic pain [0.03%]
神经痛患者中谷氨酸S1-VPL-S1皮层-丘脑-皮层回路放大机械性高敏反应
Yujiao Hu,Hao Ding,Lijing Zou et al.
Yujiao Hu et al.
Although cortical-thalamic projections contribute to pain modulation, their downstream targets and functional roles are not well defined. Here, we show that glutamatergic neurons in the hindlimb region of primary somatosensory cortex (S1HLG...
Standard rescue medication adjustments produce biased estimates of analgesic efficacy: reducing bias with multiple imputation for rescue adjustment (MIRA) [0.03%]
标准救援药物调整产生biased的止痛药疗效估计：使用救援调整多重插补(MIRA)减少偏差
Christopher J Miller,John T Farrar
Christopher J Miller
Acute pain trials rely on imputation procedures to handle the confounding impact of rescue medication on pain scores. Despite long-standing concerns about the bias of single-imputation procedures such as last-, baseline-, and worst-observat...
In vivo GCaMP imaging reveals distinct subsets of dorsal root ganglion neurons driving spontaneous pain after nerve injury in mice [0.03%]
体内GCaMP成像揭示小鼠周围神经损伤后诱发自发性疼痛的背根神经节神经元亚群
Leo C Guan,Jing Liu,Zhaoli Luo et al.
Leo C Guan et al.
Spontaneous pain is a hallmark and debilitating feature of neuropathic pain, yet the mechanisms driving spontaneous pain remain poorly understood. Although abnormal spontaneous activity (SA) in primary sensory neurons has been observed afte...
Margarita Calvo
Margarita Calvo
Functional impact of the TRPA1 H560D variant on neuropathic pain [0.03%]
TRPA1的H560D突变体对神经病理性疼痛的影响功能研究
Nicole Michelle Schottmann,Mirjam Jeanette Eberhardt,Sebastian Wehmeyer et al.
Nicole Michelle Schottmann et al.
Small fiber neuropathy (SFN) is characterized by acral burning pain and may be associated with genetic variants of the transient receptor potential ankyrin 1 (TRPA1) channel. We studied a 43-year-old male patient with SFN with severe acral ...
Peter D Drummond,Janne Gierthmühlen,Janet H Bultitude et al.
Peter D Drummond et al.