Pain prevalence and intensity in advanced pancreatic cancer: a nationwide cohort study [0.03%]
晚期胰腺癌疼痛的患病率和强度：一项全国队列研究
Aniek E Van Diepen,Merlijn U J E Graus,Simone Augustinus et al.
Aniek E Van Diepen et al.
Pain is a major concern in patients with advanced pancreatic cancer, significantly affecting quality of life, treatment tolerance, and end-of-life experience. However, data on its prevalence, course, and determinants remain limited, particu...
Neurobiology of the trigeminal ganglion in comparison to the dorsal root ganglion [0.03%]
三叉神经节与脊神经背根节的神经生物学比较研究
Shanchun Su,Minseok Kim,Wolfgang Liedtke et al.
Shanchun Su et al.
The trigeminal ganglion (TG) represents the craniofacial counterpart of the dorsal root ganglion (DRG) in the peripheral nervous system (PNS). TG and DRG are clusters of cell bodies of highly specialized sensory neurons, with TG neurons inn...
Peripheral kappa opioid receptors modulate cold hypersensitivity in a mouse model of chemotherapy-induced neuropathy [0.03%]
外周κ型阿片受体调节化疗诱发的神经病理性寒冷过敏反应
Manish K Madasu,Loc V Thang,Christian C Ohazurume et al.
Manish K Madasu et al.
Noxious cold sensation is commonly associated with peripheral neuropathies; however, there has been limited progress in understanding the mechanism. Here, we identify a novel role for peripherally expressed kappa opioid receptors [KORs] in ...
Efficacy and effectiveness of melatonin for the management of musculoskeletal pain: a systematic review and meta-analysis of placebo and active controlled trials [0.03%]
褪黑素治疗骨关节炎疼痛的有效性和有效性：安慰剂和阳性对照临床试验的系统评价和荟萃分析
Kangchao Wu,Ting Him Ho,Paula R Beckenkamp et al.
Kangchao Wu et al.
Melatonin may provide benefits for managing musculoskeletal (MSK) pain, and this review evaluated its efficacy and effectiveness on pain intensity and sleep quality. We searched 6 databases from inception to April 2025 and included randomiz...
Predictive socio-cultural factors of pain intensity, disability, and quality of life in patients with nonspecific musculoskeletal pain: a prospective cohort study [0.03%]
非特异性肌肉骨骼疼痛患者的疼痛强度、残疾和生活质量的预测性社会文化因素：前瞻性队列研究
Renske Annevelink,Sanneke Don,Jo Nijs et al.
Renske Annevelink et al.
Nonspecific musculoskeletal pain (NSMSP) presents a complex challenge in primary care due to its unequal distribution, multidimensional nature, and increasing prevalence. Understanding socio-cultural factors associated with or predicting th...
Reward-induced endogenous pain inhibition scales with action-outcome certainty in humans [0.03%]
人源奖励诱导的内源性疼痛抑制作用与行动结果确定性呈正相关
Fabrice Hubschmid,Simon Desch,Esther Florin et al.
Fabrice Hubschmid et al.
Endogenous pain modulation is believed to encompass a crucial evolutionary purpose in guiding decision-making away from harm. This is well exemplified by the idea that mechanisms of learning through error correction and endogenous pain modu...
Giulia Liberati
Giulia Liberati
Neurophysiological and psychophysical mechanisms associated with immersive virtual reality-induced hypoalgesia: a systematic review [0.03%]
有关于沉浸式虚拟现实诱导的痛觉减退的神经生理和心理物理机制的系统评价
Javier Guerra-Armas,Mar Flores-Cortes,Lucas Mamud-Meroni et al.
Javier Guerra-Armas et al.
Although growing evidence supports immersive virtual reality (IVR) as a nonpharmacological intervention for pain management, the mechanisms by which IVR induces hypoalgesia are still under debate. In this study, we review and evaluate candi...
Dissociable peripheral and central mechanisms of monoacylglycerol lipase inhibition on pain- and depression-related behaviors in a rat model of neuropathic pain [0.03%]
单酰甘油酯脂酶抑制剂在神经病理性疼痛大鼠模型中通过外周和中枢机制分别缓解与疼痛和抑郁相关的行为症状
Dongman Chao,Yin Feng,Tao Cheng et al.
Dongman Chao et al.
Chronic pain is a significant risk factor for depression, but mechanisms linking these conditions remain unclear. The endocannabinoid 2-arachidonoylglycerol, degraded by monoacylglycerol lipase (MGL), modulates both pain and mood. Although ...
Vasopressin 1A and 1B receptor-mediated antinociception in a mouse model of cortical spreading depolarization [0.03%]
血管加压素1A和1B受体介导的皮层扩散去极化小鼠模型的镇痛作用
Terry Kwamo,Madisyn Hancock,Melih Z Kaya et al.
Terry Kwamo et al.
The purpose of this study is to elucidate the role of vasopressin 1 receptors (V1Rs) in migraine with aura. Cortical spreading depolarization (SD) is a slow depolarizing wave that underlies migraine with aura, activates trigeminal nocicepto...