Changing landscape of hematopoietic and mesenchymal cells and their interactions during aging and in age-related skeletal pathologies [0.03%]
衰老过程中以及与年龄相关的骨骼疾病的造血细胞和间充质细胞及其相互作用的演变
Abhishek Chandra,Susan F Law,Robert J Pignolo
Abhishek Chandra
Aging profoundly impacts mesenchymal and hematopoietic lineage cells, including their progenitors-the skeletal stem cells (SSCs) and hematopoietic stem cells (HSCs), respectively. SSCs are crucial for skeletal development, homeostasis, and ...
Ageing, Metabolomics and Palaeoanthropology: What can the fields learn from each other? [0.03%]
衰老、代谢组学和古人类学：这三个领域能从彼此身上学到什么？
James Cole,Andrew Overall,Jennifer C French et al.
James Cole et al.
Growing old is the major risk factor for hundreds of distinct conditions. Thus, ageing of the global population will pose major social, medical, and economic challenges unless this ill health can be ameliorated or reversed. Accordingly, it ...
Conti Anastasia,Di Micco Raffaella
Conti Anastasia
The selective eradication of senescent cells using senolytic compounds represents a promising strategy to treat senescence-associated diseases like aging and cancer. However, many senolytics may cause systemic toxicity. Magkouta et al., wri...
ELN regulates cellular senescence: emerging hypothesis for a non-canonical role [0.03%]
ELN调节细胞衰老：非经典作用的新兴假说
Joanna Czarnecka-Herok,Kexin Zhu,Emmanuelle Leblanc et al.
Joanna Czarnecka-Herok et al.
Elastic fibers are well-known extracellular matrix components that are essential for elastic properties and thus function of many tissues. Tropoelastin is encoded by the ELN gene which is the main component of the elastic fibers. Elastic fi...
The impact of a selective androgen receptor modulator (RAD140) on frailty and underlying mechanisms in older male and female C57Bl/6 mice [0.03%]
选择性雄激素受体调节剂(RAD140)对老年C57Bl/6小鼠(雄性和雌性)虚弱及其潜在机制的影响
Stefan S Heinze,Maddison L Hodgins,Susan E Howlett
Stefan S Heinze
Background: Androgen receptors (AR) are promising therapeutic targets for mechanisms of aging, including chronic inflammation, lean mass loss, and worsening bone health. We investigated the impact of RAD140, a selective A...
Induction of epithelial cell senescence by SERPINE1 derived from fibroblasts in the amnion at parturition [0.03%]
分娩时羊膜成纤维细胞分泌的SERPINE1诱导上皮细胞衰老
Li-Jun Ling,Meng-Die Li,Jiang-Wen Lu et al.
Li-Jun Ling et al.
Senescence of amnion epithelial cells not only disrupts the fetal membrane structure, but also becomes a source of proinflammatory signals contributing to membrane inflammation at parturition. However, the trigger initiating their senescenc...
Molecular Signatures of Cellular Senescence in Cancer: A Critical Review of Prognostic Implications and Therapeutic Opportunities [0.03%]
癌症中衰老细胞的分子标记：对预后含义和治疗机会的关键性评论
Debora C Santos-Sousa,Solon da Rosa,Eduardo Filippi-Chiela
Debora C Santos-Sousa
Cellular senescence is a state of permanent loss of proliferative capacity. Therefore, cells that reach a senescent state prevent tumor initiation, acting as an anti-tumor mechanism. However, despite not being proliferative, senescent cells...
Exosomal Dynamics: Bridging the Gap Between Cellular Senescence and Cancer Therapy [0.03%]
外泌体动态变化：连接细胞衰老与癌症治疗的桥梁
Babu Santha Aswani,Anjana Sajeev,Mangala Hegde et al.
Babu Santha Aswani et al.
Cancer remains one of the most devastating diseases, severely affecting public health and contributing to economic instability. Researchers worldwide are dedicated to developing effective therapeutics to target cancer cells. One promising s...
Association of Cytomegalovirus Serostatus with ELOVL2 Methylation: Implications for Lipid Metabolism, Inflammation, DNA Damage, and Repair Capacity in the MARK-AGE Study Population [0.03%]
人巨细胞病毒血清状态与ELOVL2甲基化的关联：对MARK-AGE研究人群中脂质代谢，炎症，DNA损伤和修复能力的影响
Robertina Giacconi,Chiara Pirazzini,Maria Giulia Bacalini et al.
Robertina Giacconi et al.
Cytomegalovirus (CMV) infection has been linked to accelerated biological aging, potentially increasing the risk of cardiovascular disease. DNA methylation of the gene Elongation Of Very Long Chain Fatty Acids-Like 2 (ELOVL2) is a molecular...
Heart of the matter: mitochondrial dynamics and genome alterations in cardiac aging [0.03%]
问题的核心：心脏衰老中线粒体的形态动力学及基因组的变化
Claudie Gabillard-Lefort,Théophile Thibault,Guy Lenaers et al.
Claudie Gabillard-Lefort et al.
Cardiac pathological aging is a serious health issue, with cardiovascular diseases still being a leading cause of deaths worldwide. Therefore, there is an urgent need to identify culprit factors involved in this process. In the last decades...