Disentangling tau, glymphatic dysfunction and astrocytic activation in amyloid-positive Alzheimer's disease [0.03%]
解开淀粉样蛋白阳性的阿尔茨海默病中的tau、glymphatic功能障碍和星形胶质细胞活化的关系
Hsin-I Chang,Shih-Wen Chen,Shu-Hua Huang et al.
Hsin-I Chang et al.
Alzheimer's disease (AD) features tau pathology, neurodegeneration, and cognitive decline. Dysfunction of the glymphatic system, which clears pathological proteins, and astrocytic activation may exacerbate neurodegeneration. We investigated...
Emanuele Marzetti,Riccardo Calvani,Helio José Coelho-Junior et al.
Emanuele Marzetti et al.
Age-related skeletal muscle decline is a major contributor to frailty, functional impairment, and loss of independence in advanced age. This process is characterized by selective atrophy of type II fibers, impaired excitation-contraction co...
Kun Li,Xiaolin Qiu,Qiqi Yang et al.
Kun Li et al.
Alzheimer's disease (AD) is one of the most prevalent diseases in the older population. AD causes progressive cognitive and behavioral impairment, but current treatments are unable to slow or prevent the progression of this disease. Thus, i...
ABI3BP Deficiency Alleviates Ang II-Induced VSMC Senescence through the NRF2 Signalling Pathway [0.03%]
ABl3BP缺陷通过NRF2信号通路缓解Ang II诱导的血管平滑肌细胞衰老
Aiqiu Mao,Qiang Tu,Huaqiang Xie et al.
Aiqiu Mao et al.
Vascular aging is a critical independent risk factor for cardiovascular disease (CVD), yet its precise molecular mechanisms remain poorly understood. In this study, we generated an ABI3BP knockout mouse to investigate the role of ABI3BP def...
DKK3, regulated by FOXF1-EZH2 axis, takes action on tubular epithelial cells senescence to trigger glomerular endothelial cells ferroptosis involving in renal fibrosis [0.03%]
由FOXF1-EZH2轴调节的DKK3通过作用于肾小管上皮细胞衰老来触发肾小球内皮细胞铁死亡从而参与肾脏纤维化
Huiling Cao,Yanxia Chen,Jinjing Huang et al.
Huiling Cao et al.
Chronic kidney disease (CKD) can be accelerated by renal fibrosis. Dickkopf-3 (DKK3) plays a role in regulating renal fibrosis, while tubular cell senescence contributes to fibrosis development. Here, the role and mechanism of DKK3 on senes...
Mechanism of FTO-Mediated m6A Demethylation Regulation of YAP1 in Nucleus Pulposus Cell Senescence [0.03%]
FTO介导的YAP1去甲基化调节机制促进椎间盘软骨终板细胞衰老
Rui Sun,Xiao-Tao Wu,Hang Shi et al.
Rui Sun et al.
Nucleus pulposus (NP) cell senescence is a critical factor in the progression of intervertebral disc degeneration (IVDD). Our analysis demonstrates that FTO and YAP1 expression levels are significantly diminished in degenerative NP tissues ...
Electrical Brain Activity in Centenarians: Neurophysiological EEG Markers in resilient brain Ageing [0.03%]
百岁老人的脑电活动：弹性脑衰老的神经生理EEG标志物研究
Fabrizio Vecchio,Chiara Pappalettera,Alessia Cacciotti et al.
Fabrizio Vecchio et al.
Centenarians are an increasing population, in particular in high income countries. Studying cognitively intact Centenarians' brain becomes fundamental to understand physiological ageing and how it diverges from pathological one. Resting sta...
Circulating microRNAs and cross sectional and longitudinal measurements of physical functioning and frailty: an explorative study in older twins [0.03%]
循环microRNA与老年人身体功能的横断面和纵向测量：一项在老年双胞胎中的探索性研究
Rossella La Grotta,Cecilie Agergaard Sørensen,Asmus Cosmos Skovgaard et al.
Rossella La Grotta et al.
During aging, physical functioning declines, and disability and frailty increase; phenotypes which are bidirectionally linked. MicroRNAs (miRNAs) are epigenetic regulators of various physiological processes and suggested aging biomarkers. H...
Genome-Wide RNAi Analysis in Adult Caenorhabditis elegans Unveils Genes Controlling Age-Related Fat Accumulation [0.03%]
基于成体秀丽隐杆线虫的全基因组RNAi分析发现控制衰老相关脂肪蓄积的基因
Chunxia Qin,Zicheng Liu,Duo Duan et al.
Chunxia Qin et al.
Fat accumulation with aging occurs in adults across species, yet its mechanisms remain poorly understood, partly due to limited studies focused specifically targeting adulthood. Here, we present the first genome-wide analysis of age-associa...
Energetic cost of biosynthesis modulates the growth-longevity tradeoff in mice: Quantitative insights into four lifespan-altering manipulations [0.03%]
生命能量消耗成本调节了小鼠生长与寿命的权衡关系——四种延长寿命方法的量化研究新进展
Chen Hou,Fahimeh Taheri
Chen Hou
Life history theory proposes a tradeoff between growth rate and lifespan, typically explained by the allocation of limited energy resources between somatic growth and maintenance. However, this explanation does not give a complete picture o...