Jitendra Kumar Chaudhary,Ajay Kumar Danga,Anita Kumari et al.
Jitendra Kumar Chaudhary et al.
Stem cell functions and ageing are deeply interconnected, continually influencing each other in multiple ways. Stem cells play a vital role in organ maintenance, regeneration, and homeostasis, all of which decline over time due to gradual r...
Transcriptomic and Epigenomic Signatures of Liver Metabolism and Insulin Sensitivity in Aging Mice [0.03%]
小鼠衰老过程中肝脏代谢和胰岛素敏感性的转录组和表观基因组特征
John T González,Olivia H Scharfman,Wanling Zhu et al.
John T González et al.
Age-related declines in insulin sensitivity and glucose metabolism contribute to metabolic disease. Despite the liver's central role in glucose homeostasis, a comprehensive phenotypic characterization and concurrent molecular analysis of in...
HRasV12 induces apoptosis, not cellular senescence in mouse skeletal myoblasts [0.03%]
HRasV12诱导小鼠骨骼肌母细胞凋亡而非细胞衰老现象
Shinichiro Suzuki,Takuya Fukunaga,Tatsuya Hayashi et al.
Shinichiro Suzuki et al.
Aging is a key risk factor for sarcopenia, a progressive disorder affecting skeletal muscle. One hallmark of aging is cellular senescence. To investigate cellular senescence in mouse skeletal myoblasts, we attempted to induce cellular senes...
Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3 [0.03%]
亨廷顿病MJD/SCA3动物模型寿命延长的遗传操作的不同效应
Marta Daniela Costa,Jorge Diogo Da Silva,Dulce Almeida et al.
Marta Daniela Costa et al.
Aging is a natural biological process, but evidence suggests that some aspects of aging can be delayed and reduce the prevalence of neurodegenerative diseases, for which aging is a key risk factor. In a neuronal Caenorhabditis elegans model...
KAEMPFEROL, A WIDELY INGESTED DIETARY FLAVONOID AND SUPPLEMENT, ENHANCES BIOLOGICAL PERFORMANCE VIA HORMESIS, ESPECIALLY FOR AGEING-RELATED PROCESSES [0.03%]
番石榴素通过激素作用尤其是与衰老相关的机制增强生物性能
Edward J Calabrese,Peter Pressman,A Wallace Hayes et al.
Edward J Calabrese et al.
Kaempferol is a polyphenol in various fruits and vegetables. It is also commercially developed and sold to consumers as a supplement. It has been extensively assessed in clinical trials for clinical utility based upon its numerous experimen...
Actinomyces viscosus promotes neuroprotection in C. elegans models of Parkinson's disease [0.03%]
黏液类芽胞杆菌促进帕金森病线虫模型中的神经保护作用
G Sophie Ngana,Mercedes A Di Bernardo,Michael G Surette et al.
G Sophie Ngana et al.
Parkinson's Disease is characterized by selective degeneration of dopaminergic neurons, primarily in the substantia nigra pars compacta, as well as accumulation of alpha-synuclein enriched protein aggregates within neurons. The pathogenesis...
miR-132-3p is down-regulated in plasma and CD171+ extracellular vesicles isolated from patients with mild Alzheimer's disease [0.03%]
血浆和CD171+细胞外囊泡中的miR-132-3p在轻度阿尔茨海默病患者中下调
Matilde Sbriscia,Tatiana Spadoni,Patrizia Ambrogini et al.
Matilde Sbriscia et al.
Alzheimer's disease (AD), the most prevalent neurodegenerative disorder in aging populations, demands minimally invasive biomarkers for early diagnosis and monitoring. Circulating microRNAs (miRNAs) show promise as such biomarkers. In this ...
Towards defining optimal concentrations of micronutrients in adults to optimize health [0.03%]
确定成人微量元素的理想浓度以优化健康的趋势
Muhammad Daniel Azlan Mahadzir,Sheryl Tan,Sandalova Elena et al.
Muhammad Daniel Azlan Mahadzir et al.
Micronutrients are essential for maintaining physiological homeostasis and optimizing healthspan, defined as the years lived in good health without chronic diseases or disabilities. Despite increasing global life expectancy, improvements in...
miR-34a-5p/MARCHF8/ADAM10 axis in the regulation of vascular endothelial cell dysfunction and senescence [0.03%]
MIR-34A-5P/MARCHF8/ADAM10信号轴在血管内皮细胞功能障碍及衰老中的作用机制研究
Zonghao Qian,Yuzhen Huang,Ni Yang et al.
Zonghao Qian et al.
Vascular aging is a key driver of age-related cardiovascular and metabolic diseases, with endothelial dysfunction and senescence as a central mechanism. In our recent study, we observed elevated ADAM10 protein levels in senescent endothelia...
ANRIL Modulates Endothelial Senescence and Angiogenesis Through SASP-Driven miR146a Regulation in Age-Related Vascular Dysfunction [0.03%]
ANRIL通过SASP驱动的miR146a调节来调控年龄相关血管功能障碍中的内皮细胞衰老和血管生成
Kechuan Lin,Xin Luo,Can Du et al.
Kechuan Lin et al.
Vascular aging, marked by endothelial cell (EC) dysfunction and compromised angiogenesis, is a central driver of age-related ischemic diseases. Although lncRNAs have emerged as pivotal regulators of endothelial function, their specific role...