Unlocking diagnosis of sarcopenia: The role of circulating biomarkers - A clinical systematic review [0.03%]
sarcopenia诊断的循环生物标志物作用及临床系统性综述
F Veronesi,F Salamanna,V Borsari et al.
F Veronesi et al.
Sarcopenia, the gradual loss of muscle mass, strength, and function with age, poses a significant risk to older adults, making early diagnosis crucial for preventing disability and enhancing quality of life. Biomarkers are vital for the ear...
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury [0.03%]
脊髓缺血再灌注损伤中p53/HIF-1α调控神经元衰老及自噬反应
Xingzhen Liu,Jia Wang,Kangping Shen et al.
Xingzhen Liu et al.
Objection: Spinal cord injury (SCI)-induced hindlimb dysfunction affects the physical and mental health of patients. There is growing evidence suggesting that the recovery capacity of elderly SCI patients is poorer than t...
Differential Plin5 response to high-fat diet in cardiomyocytes isolated from young and aged mice [0.03%]
青年和老年小鼠分离的心肌细胞对高脂饮食的Plin5反应差异性研究
Patricia Baumgarten,Tobias Jung,Christiane Ott et al.
Patricia Baumgarten et al.
This study investigates the differences in the heart response to an 8-week high-fat diet between young and aged mice. Isolated cardiomyocytes reveal a significant lower level in the lipid droplet-associated protein Plin5 in aged mice. High-...
The abundance change of age-regulated secreted proteins affects lifespan of C. elegans [0.03%]
年龄调控的分泌蛋白丰度变化影响秀丽隐杆线虫寿命
Prasun Kumar Bhunia,Vishwajeet Raj,Prasad Kasturi
Prasun Kumar Bhunia
Proteome integrity is vital for survival and failure to maintain it results in uncontrolled protein abundances, misfolding and aggregation which cause proteotoxicity. In multicellular organisms, proteotoxic stress is communicated among tiss...
Convergence between brain aging and Alzheimer's disease: Focus on mitochondria [0.03%]
大脑衰老与阿尔茨海默病的汇聚关系：聚焦线粒体
Salvatore Vaiasicca,Marta Balietti,Lisa Bevilacqua et al.
Salvatore Vaiasicca et al.
Alzheimer's disease (AD) accounts for the majority of dementia cases, with aging being the primary risk factor for developing this neurodegenerative condition. Aging and AD share several characteristics, including the formation of amyloid p...
Design of the VOILA-intervention study: A 12-week nutrition and resistance exercise intervention in metabolic or mobility compromised Dutch older adults and the response on immune-metabolic, gut and muscle health parameters [0.03%]
VOILA干预研究设计：一项针对荷兰代谢或活动能力受损老年人的12周营养和抗阻锻炼干预以及对免疫-代谢、肠道和肌肉健康参数的影响研究
C S Kramer,A Monsegue,J Morwani-Mangnani et al.
C S Kramer et al.
Background: Exercise and nutrition interventions can slow ageing-induced decline in physiology. However, effects are heterogeneous and usually studied separately per outcome domain. In the VOILA study, we simultaneously s...
Randomized Controlled Trial
Mechanisms of ageing and development. 2024 Dec:222:112002. DOI:10.1016/j.mad.2024.112002 2024
Challenges of infectious diseases in older adults: From immunosenescence and inflammaging through antibiotic resistance to management strategies [0.03%]
老年人感染性疾病的挑战：从免疫衰老和炎症老化到抗生素耐药性和管理策略
Francesca Mancinetti,Anna Marinelli,Virginia Boccardi et al.
Francesca Mancinetti et al.
Infectious diseases in older adults present a significant challenge to the healthcare system, marked by increased morbidity, mortality, and rising costs of care. Age-related changes (ARCs) in the immune system, including immunosenescence an...
Impact of senescence cell signature in patients with non-small cell carcinoma and melanoma receiving PD-L1/PD-1 inhibitors [0.03%]
PD-L1/PD-1抑制剂治疗非小细胞肺癌和黑色素瘤患者的衰老细胞谱型影响研究
Young Wha Koh,Jae-Ho Han,Seokjin Haam et al.
Young Wha Koh et al.
Tumor cell senescence plays a crucial role in tumor immunity. We investigated whether the senescent cell signature (SCS) could predict prognosis in non-small cell carcinoma (NSCLC) and melanoma datasets treated with PD-L1/PD-1 inhibitors. P...
Francisca Franulic,Felipe Salech,Daniel Rivas et al.
Francisca Franulic et al.
Osteosarcopenia is a major driver of functional loss and a risk factor for falls, fractures, disability and mortality in older adults, urgently requiring the development of effective interventions to address it. The hallmarks of aging provi...
Sirtuin 3 drives sex-specific responses to age-related changes in mouse embryonic fibroblasts [0.03%]
沉默调节蛋白3驱动衰老小鼠胚胎成纤维细胞性别特异性变化反应
Ena Šimunić,Iva I Podgorski,Marija Pinterić et al.
Ena Šimunić et al.
The aging process is a complex phenomenon characterised by a gradual decline in physiological functions and an increased susceptibility to age-related diseases. An important factor in aging is mitochondrial dysfunction, which leads to an ac...