Compatibility and comparative analysis of chronological and biological aging between the legacy 450K and the EPIC v2.0 arrays [0.03%]
legacy 450k与EPIC阵列在时序衰老和生物学衰老上的兼容性及比较分析
Sven De Pourcq,Pei-Lun Kuo,Ann Zenobia Moore et al.
Sven De Pourcq et al.
Several epigenetic clocks based on DNA methylation arrays have been developed to evaluate biological aging. However, there is limited information on how the newer EPIC v2.0 arrays affect clock estimations, which lack probes initially presen...
DHT ameliorates cardiac aging in progeroid mice by XRCC4-mediated genome stabilization [0.03%]
依托泊苷通过XRCC4介导的基因组稳定改善早衰小鼠的心脏衰老
Rui Jiang,Hao Wang,Weina Zhang et al.
Rui Jiang et al.
Cardiovascular compromise is the primary cause of death in Hutchinson-Gilford Progeria Syndrome (HGPS), a lethal segmental premature aging disorder; however, no therapies directly target its underlying cardiac pathology. Our prior work esta...
Expression of concern: Regulation of β-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease [0.03%]
表达关切：胆固醇喂养兔子脑内β淀粉样蛋白水平的调节——一种散发性阿尔茨海默病模式体系的研究
R P Jaya Prasanthi,Eric Schommer,Sarah Thomasson et al.
R P Jaya Prasanthi et al.
cGAS-STING signaling is blunted in senescent macrophages and monocytes in obesity [0.03%]
肥胖会抑制衰老巨噬细胞和单核细胞中的cGAS-STING信号传续发生
Carine Raquel Richter Schmitz,Lucas Kich Grun,Bruno Kendi Makiyama et al.
Carine Raquel Richter Schmitz et al.
Introduction: The cGAS-STING pathway is essential for immunity, detecting cytosolic DNA to trigger defense mechanisms and sterile inflammation linked to aging, obesity, and chronic inflammatory diseases. This study examin...
Association between metabolic profile and cognitive frailty in community-dwelling older adults: An eight-year cohort study [0.03%]
社区老年人代谢谱与认知脆弱性的相关性：一项为期八年的队列研究
Te-Hsuan Huang,Yen-Ching Chen,Ching-Yu Lin et al.
Te-Hsuan Huang et al.
Limited studies have explored the link between metabolic profiles and cognitive frailty, its temporal relationship is especially lacking. This study aimed to identify metabolic patterns associated with cognitive frailty over time. This eigh...
The TGF-β1-oxidative stress axis underlies accelerated senescence of endothelial cells exposed to serum from hypertensive patients [0.03%]
高血压患者血清诱导的内皮细胞加速衰老与TGF-β1氧化应激轴相关
Paweł Uruski,Justyna Mikuła-Pietrasik,Andrzej Tykarski et al.
Paweł Uruski et al.
Background: There is a bidirectional link between hypertension (HT) and cellular senescence of endothelial cells (ECs). However, the mechanisms underlying EC senescence in patients with HT are not yet fully understood. ...
Causes and consequences of chromosomal cohesin loss: Novel insights for mechanisms of aging-related oocyte aneuploidy [0.03%]
染色体cohesin丢失的原因及后果：关于衰老相关卵细胞非整倍体机制的新见解
Lu-Lu Fu,Jing-Shun Zhang,Xue-Ying Zhang et al.
Lu-Lu Fu et al.
Female fertility sharply declines from the mid-thirties of their life, mainly due to age-related decreases in oocyte quality and quantity. Among numerous interconnected maternal factors, an increase in the incidence of aneuploidy caused by ...
Ischemic Stroke and Comorbidities: Impact on Recovery and the Role of Genetics and Epigenetics [0.03%]
缺血性卒中及其共病对康复的影响及遗传和表观遗传学的作用
Andreea Cercel,Abuzan Mihaela,Thorsten R Doeppner et al.
Andreea Cercel et al.
Ischemic stroke (IS) remains a leading cause of long-term disability and mortality worldwide, with recovery outcomes shaped by the interplay between acute vascular injury, pre-existing comorbidities, and individual molecular profiles. Commo...
Ashwagandha Withanolides, Withaferin-A, and Withanone for Natural Interventions in Aging and Obesity [0.03%]
阿育吠陀药用植物 Ashwagandha 中 Withanolide、Withaferin-A 和 Withanone 成分用于抗衰老和肥胖的天然干预措施研究进展
Ren Yoshitomi,Rajeswari Nanda,Kazumi Hirano et al.
Ren Yoshitomi et al.
Aging and obesity are closely connected, with obesity being a major risk factor for many age-related diseases caused by chronic inflammation and mobility problems. Lifestyle choices such as good nutrition, including medicinal herbs, and exe...
Age-Related Alterations in the Expression of Mesencephalic Astrocyte-derived Neurotrophic Factor in the Brain and Their Impact on Neurobehavioral Functions [0.03%]
脑内mesencephalic astrocyte衍生的神经营养因子表达的老年改变及其对神经行为功能的影响
Di Hu,Wen Wen,Hui Li et al.
Di Hu et al.
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a neurotrophic protein localized in the endoplasmic reticulum (ER) and pivotally involved in maintaining ER homeostasis. The ER is central to protein synthesis, folding, degradat...