Conti Anastasia,Di Micco Raffaella
Conti Anastasia
The selective eradication of senescent cells using senolytic compounds represents a promising strategy to treat senescence-associated diseases like aging and cancer. However, many senolytics may cause systemic toxicity. Magkouta et al., wri...
ELN regulates cellular senescence: emerging hypothesis for a non-canonical role [0.03%]
ELN调节细胞衰老：非经典作用的新兴假说
Joanna Czarnecka-Herok,Kexin Zhu,Emmanuelle Leblanc et al.
Joanna Czarnecka-Herok et al.
Elastic fibers are well-known extracellular matrix components that are essential for elastic properties and thus function of many tissues. Tropoelastin is encoded by the ELN gene which is the main component of the elastic fibers. Elastic fi...
The impact of a selective androgen receptor modulator (RAD140) on frailty and underlying mechanisms in older male and female C57Bl/6 mice [0.03%]
选择性雄激素受体调节剂(RAD140)对老年C57Bl/6小鼠(雄性和雌性)虚弱及其潜在机制的影响
Stefan S Heinze,Maddison L Hodgins,Susan E Howlett
Stefan S Heinze
Background: Androgen receptors (AR) are promising therapeutic targets for mechanisms of aging, including chronic inflammation, lean mass loss, and worsening bone health. We investigated the impact of RAD140, a selective A...
Induction of epithelial cell senescence by SERPINE1 derived from fibroblasts in the amnion at parturition [0.03%]
分娩时羊膜成纤维细胞分泌的SERPINE1诱导上皮细胞衰老
Li-Jun Ling,Meng-Die Li,Jiang-Wen Lu et al.
Li-Jun Ling et al.
Senescence of amnion epithelial cells not only disrupts the fetal membrane structure, but also becomes a source of proinflammatory signals contributing to membrane inflammation at parturition. However, the trigger initiating their senescenc...
Molecular Signatures of Cellular Senescence in Cancer: A Critical Review of Prognostic Implications and Therapeutic Opportunities [0.03%]
癌症中衰老细胞的分子标记：对预后含义和治疗机会的关键性评论
Debora C Santos-Sousa,Solon da Rosa,Eduardo Filippi-Chiela
Debora C Santos-Sousa
Cellular senescence is a state of permanent loss of proliferative capacity. Therefore, cells that reach a senescent state prevent tumor initiation, acting as an anti-tumor mechanism. However, despite not being proliferative, senescent cells...
Exosomal Dynamics: Bridging the Gap Between Cellular Senescence and Cancer Therapy [0.03%]
外泌体动态变化：连接细胞衰老与癌症治疗的桥梁
Babu Santha Aswani,Anjana Sajeev,Mangala Hegde et al.
Babu Santha Aswani et al.
Cancer remains one of the most devastating diseases, severely affecting public health and contributing to economic instability. Researchers worldwide are dedicated to developing effective therapeutics to target cancer cells. One promising s...
Association of Cytomegalovirus Serostatus with ELOVL2 Methylation: Implications for Lipid Metabolism, Inflammation, DNA Damage, and Repair Capacity in the MARK-AGE Study Population [0.03%]
人巨细胞病毒血清状态与ELOVL2甲基化的关联：对MARK-AGE研究人群中脂质代谢，炎症，DNA损伤和修复能力的影响
Robertina Giacconi,Chiara Pirazzini,Maria Giulia Bacalini et al.
Robertina Giacconi et al.
Cytomegalovirus (CMV) infection has been linked to accelerated biological aging, potentially increasing the risk of cardiovascular disease. DNA methylation of the gene Elongation Of Very Long Chain Fatty Acids-Like 2 (ELOVL2) is a molecular...
Heart of the matter: mitochondrial dynamics and genome alterations in cardiac aging [0.03%]
问题的核心：心脏衰老中线粒体的形态动力学及基因组的变化
Claudie Gabillard-Lefort,Théophile Thibault,Guy Lenaers et al.
Claudie Gabillard-Lefort et al.
Cardiac pathological aging is a serious health issue, with cardiovascular diseases still being a leading cause of deaths worldwide. Therefore, there is an urgent need to identify culprit factors involved in this process. In the last decades...
The relationship between physical activity and telomere length in women: A systematic review [0.03%]
体力活动和女性端粒长度的关系：系统回顾
Jeni Page,Catherine Stephens,Melissa Richard et al.
Jeni Page et al.
Telomere length (TL) is a biomarker of cellular aging with variations observed by sex, age, race, and ethnicity. Prior studies have suggested that physical activity (PA) may positively impact TL by potentially elongating telomeres and slowi...
Vascular Participation in Bone Healing: Implications Related to Advancing Age and Morbidity [0.03%]
血管在骨愈合中的作用：与年龄增大和疾病的关联影响
Rhonda D Prisby
Rhonda D Prisby
Fracture non-union and the related morbidities represent a global health concern. While many factors are necessary for proper bone healing following fracture, the vascular system is requisite. Important considerations include vascular morph...