cGAS-STING signaling is blunted in senescent macrophages and monocytes in obesity [0.03%]
肥胖会抑制衰老巨噬细胞和单核细胞中的cGAS-STING信号传续发生
Carine Raquel Richter Schmitz,Lucas Kich Grun,Bruno Kendi Makiyama et al.
Carine Raquel Richter Schmitz et al.
Introduction: The cGAS-STING pathway is essential for immunity, detecting cytosolic DNA to trigger defense mechanisms and sterile inflammation linked to aging, obesity, and chronic inflammatory diseases. This study examin...
Association between metabolic profile and cognitive frailty in community-dwelling older adults: An eight-year cohort study [0.03%]
社区老年人代谢谱与认知脆弱性的相关性：一项为期八年的队列研究
Te-Hsuan Huang,Yen-Ching Chen,Ching-Yu Lin et al.
Te-Hsuan Huang et al.
Limited studies have explored the link between metabolic profiles and cognitive frailty, its temporal relationship is especially lacking. This study aimed to identify metabolic patterns associated with cognitive frailty over time. This eigh...
The TGF-β1-oxidative stress axis underlies accelerated senescence of endothelial cells exposed to serum from hypertensive patients [0.03%]
高血压患者血清诱导的内皮细胞加速衰老与TGF-β1氧化应激轴相关
Paweł Uruski,Justyna Mikuła-Pietrasik,Andrzej Tykarski et al.
Paweł Uruski et al.
Background: There is a bidirectional link between hypertension (HT) and cellular senescence of endothelial cells (ECs). However, the mechanisms underlying EC senescence in patients with HT are not yet fully understood. ...
Causes and consequences of chromosomal cohesin loss: Novel insights for mechanisms of aging-related oocyte aneuploidy [0.03%]
染色体cohesin丢失的原因及后果：关于衰老相关卵细胞非整倍体机制的新见解
Lu-Lu Fu,Jing-Shun Zhang,Xue-Ying Zhang et al.
Lu-Lu Fu et al.
Female fertility sharply declines from the mid-thirties of their life, mainly due to age-related decreases in oocyte quality and quantity. Among numerous interconnected maternal factors, an increase in the incidence of aneuploidy caused by ...
Ischemic Stroke and Comorbidities: Impact on Recovery and the Role of Genetics and Epigenetics [0.03%]
缺血性卒中及其共病对康复的影响及遗传和表观遗传学的作用
Andreea Cercel,Abuzan Mihaela,Thorsten R Doeppner et al.
Andreea Cercel et al.
Ischemic stroke (IS) remains a leading cause of long-term disability and mortality worldwide, with recovery outcomes shaped by the interplay between acute vascular injury, pre-existing comorbidities, and individual molecular profiles. Commo...
Ashwagandha Withanolides, Withaferin-A, and Withanone for Natural Interventions in Aging and Obesity [0.03%]
阿育吠陀药用植物 Ashwagandha 中 Withanolide、Withaferin-A 和 Withanone 成分用于抗衰老和肥胖的天然干预措施研究进展
Ren Yoshitomi,Rajeswari Nanda,Kazumi Hirano et al.
Ren Yoshitomi et al.
Aging and obesity are closely connected, with obesity being a major risk factor for many age-related diseases caused by chronic inflammation and mobility problems. Lifestyle choices such as good nutrition, including medicinal herbs, and exe...
Age-Related Alterations in the Expression of Mesencephalic Astrocyte-derived Neurotrophic Factor in the Brain and Their Impact on Neurobehavioral Functions [0.03%]
脑内mesencephalic astrocyte衍生的神经营养因子表达的老年改变及其对神经行为功能的影响
Di Hu,Wen Wen,Hui Li et al.
Di Hu et al.
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a neurotrophic protein localized in the endoplasmic reticulum (ER) and pivotally involved in maintaining ER homeostasis. The ER is central to protein synthesis, folding, degradat...
Circulating Mitokines GDF-15 and FGF21 are associated with Frailty, Sarcopenia, and Malnutrition in Older Adults: Evidence from the FRASNET Study [0.03%]
循环线粒体细胞因子GDF-15和FGF21与老年人虚弱、肌肉减少症和营养不良的关系：来自FRASNET研究的证据
Sarah Damanti,Clara Sciorati,Rebecca De Lorenzo et al.
Sarah Damanti et al.
Background: Mitochondria-derived GDF15 and FGF21, known as mitokines, are emerging biomarkers of metabolic stress and aging-related decline. Their roles in energy balance, inflammation, and muscle metabolism suggest poten...
An atlas of age- and sex-related volumetric alterations of grey matter in subcortical regions: the case of 46,111 UK Biobank participants [0.03%]
基于46111名英国生物库(UK Biobank)参与者的皮层下区域灰质年龄和性别变化的图谱分析
Fatemeh Tabassi Mofrad,Chris Patrick Pflanz,John Gallacher
Fatemeh Tabassi Mofrad
Ageing is typically accompanied by neuroanatomical changes in brain structure, making it crucial to distinguish normal age-related alterations from pathological ones. Despite this importance, a standardized benchmark for identifying abnorma...
Diminished CEACAM1 level plays a critical role in age-related hepatic fibrosis [0.03%]
CEACAM1水平降低在年龄相关性肝纤维化中起关键作用
Sobia Zaidi,Suman Asalla,Raziyeh Abdolahipour et al.
Sobia Zaidi et al.
Background: Hepatic fibrosis increases with aging, but its physiological progression and underlying mechanisms remain poorly defined. Given that CEACAM1 repression causes metabolic dysfunction and liver injury, the curren...