SRC Suppression Attenuates Vascular Aging by Activating FUNDC1-Dependent Mitophagy [0.03%]
SRC抑制通过激活FUNDC1依赖性线粒体自噬来缓解血管衰老
Linghuan Wang,Yan Ma,Tianhu Wang et al.
Linghuan Wang et al.
Vascular smooth muscle cell senescence contributes critically to vascular remodeling and atherosclerosis, with mitochondrial dysfunction and impaired mitophagy recognized as major contributors. SRC, a stress-responsive tyrosine kinase, has ...
Inflammatory and genetic mechanisms mediate the association between frailty and incident atopic dermatitis in middle-aged and elderly adults [0.03%]
炎症和遗传机制介导了中老年人衰弱与特应性皮炎发病之间的关系
Peizhi Deng,Siyu Tang,Jinron Zeng et al.
Peizhi Deng et al.
Frailty is linked to many chronic conditions, but its relationship with atopic dermatitis (AD) remains insufficiently defined. We assessed whether frailty predisposes to incident AD and explored inflammatory and genetic mechanisms. Baseline...
Apelin-13 activates TFEB-mediated autophagy via AMPK to attenuate senescence and pyroptosis in nucleus pulposus cells during intervertebral disc degeneration [0.03%]
阿皮林通过AMPK激活TFEB介导的自噬减轻椎间盘细胞衰老和焦亡以治疗椎间盘退变性疾病
Yuhang Gong,Jie Xiang,Ben Wang et al.
Yuhang Gong et al.
Intervertebral disc degeneration (IDD) is an aging-associated disorder driven by chronic inflammation. Impaired autophagy is a hallmark of disc aging, but its upstream regulation remains unclear. Here, we identify Apelin-13 (APL13) as an en...
How to measure, analyze, and interpret age-related changes in Caenorhabditis elegans: Lessons for mechanistic and evolutionary theories of aging [0.03%]
如何在秀丽隐杆线虫中测量、分析和解读与年龄相关的改变：机制及衰老进化理论的启示
Zuzana Kocsisova,Brian M Egan,Andrea Scharf et al.
Zuzana Kocsisova et al.
Aging is characterized by progressive degenerative changes in tissue organization and function, some of which increase the probability of mortality. Major goals of aging research are to elucidate the series of events that cause degenerative...
Mathew Shuen,Regis R Lamberts,Sean Coffey et al.
Mathew Shuen et al.
Ageing populations present substantial healthcare challenges, with cardiovascular disease (CVD) remaining the predominant cause of morbidity and mortality globally. Cardiac ageing is characterised by progressive cellular and molecular chang...
Qiliang Yin,Yan Zhang,Xingcheng Yi et al.
Qiliang Yin et al.
It is generally believed that hematopoietic aging is a major driver or contributor of human aging. The hematopoietic system undergoes physiological or pathological changes with aging, which drive or contribute to the aging of almost all sys...
Christopher Hofmann,Hartmut Geiger
Christopher Hofmann
The colon is one of the gastrointestinal organs most profoundly affected by aging. Recent advances in our understanding of both colonic physiology and the general mechanisms of aging have significantly expanded our knowledge of the types an...
Compatibility and comparative analysis of chronological and biological aging between the legacy 450K and the EPIC v2.0 arrays [0.03%]
legacy 450k与EPIC阵列在时序衰老和生物学衰老上的兼容性及比较分析
Sven De Pourcq,Pei-Lun Kuo,Ann Zenobia Moore et al.
Sven De Pourcq et al.
Several epigenetic clocks based on DNA methylation arrays have been developed to evaluate biological aging. However, there is limited information on how the newer EPIC v2.0 arrays affect clock estimations, which lack probes initially presen...
DHT ameliorates cardiac aging in progeroid mice by XRCC4-mediated genome stabilization [0.03%]
依托泊苷通过XRCC4介导的基因组稳定改善早衰小鼠的心脏衰老
Rui Jiang,Hao Wang,Weina Zhang et al.
Rui Jiang et al.
Cardiovascular compromise is the primary cause of death in Hutchinson-Gilford Progeria Syndrome (HGPS), a lethal segmental premature aging disorder; however, no therapies directly target its underlying cardiac pathology. Our prior work esta...
Expression of concern: Regulation of β-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease [0.03%]
表达关切：胆固醇喂养兔子脑内β淀粉样蛋白水平的调节——一种散发性阿尔茨海默病模式体系的研究
R P Jaya Prasanthi,Eric Schommer,Sarah Thomasson et al.
R P Jaya Prasanthi et al.