Targeting mitophagy in the heart: Exploring the therapeutic potential of MicroRNAs [0.03%]
靶向心肌细胞自噬：探索MicroRNA的治疗潜力
Amin Javadifar,Masoud Tahani,Sorousha Khayat et al.
Amin Javadifar et al.
Mitophagy, a selective form of autophagy, plays an indispensable role in preserving mitochondrial integrity by eliminating dysfunctional mitochondria, thereby sustaining cellular homeostasis. This process is particularly critical in cardiom...
Dietary ingredients inducing cellular senescence in animals and humans: A systematic review [0.03%]
动物和人类细胞衰老的饮食因素：系统性综述
Lihuan Guan,Kristina Zdantsevich,Elena Sandalova et al.
Lihuan Guan et al.
Background: Cellular senescence (CS) is a hallmark of ageing and age-related diseases. While dietary interventions are often explored to reduce CS, less is known about dietary ingredients that induce it. This study system...
Kalyani Pandya,Annabel Menendez,Mark G MacAskill et al.
Kalyani Pandya et al.
Age and sex exert profound influences on the heart, shaping its structure, function, and susceptibility to disease. Among the myriad of changes driven by age and sex, alterations in the extracellular matrix (ECM), particularly collagen infl...
The combination of GDF15, FGF21, sRAGE and NfL plasma levels can identify frailty in community-dwelling people across old age [0.03%]
GDF15、FGF21、sRAGE和NfL的血浆水平联合可用于识别社区居住老年人中的衰弱状态
Maria Conte,Federica Sevini,Giuseppe Conte et al.
Maria Conte et al.
Frailty is a complex medical condition characterized by decline in physiological functions and global health of older people, representing a strong risk factor for disability, hospitalization, and mortality. The identification of biomarkers...
Elena Carbone,Elisa Fabrizi,Roberto Rivabene et al.
Elena Carbone et al.
Studying aging and risk factors associated with chronic non-communicable diseases is increasingly relevant due to the progressive aging of the global population. Risk factors have focused on diet, physical exercise, cognitive activity, and ...
Plasma metabolomic profiles reveal sex-specific response to an oral glucose tolerance test in late middle-aged adults [0.03%]
基于血浆代谢组揭示口服葡萄糖耐量试验在中年成人中的性别差异响应
C M Donado-Pestana,L Rodrigues,M Rundle et al.
C M Donado-Pestana et al.
Sex is a key determinant of human phenotype, with males and females exhibiting distinct anthropometric and metabolic features that influence disease susceptibility. This study investigated sex-specific metabolic differences in late middle-a...
Interspecific interactions and aging: Prediction of gerogenic bacteria and critical human protein targets of microbial infections [0.03%]
种间互作与衰老：预测致龄细菌及微生物感染的人源蛋白关键靶标
Yuping Dai,Ni Boussaguet,Jérôme Teulière et al.
Yuping Dai et al.
Bacteria permeate every niche of the human body with major consequences on our health and senescence that have not been fully described. Here, we predict which bacteria and which bacterial proteins could interfere with proteins associated w...
Cyr61 Promotes D-gal-induced Aging C2C12 Cell Fibrosis by Modulating Wnt/β-catenin Signaling Pathways [0.03%]
Cyr61通过调节Wnt/β-catenin信号通路促进D-半乳糖诱导的C2C12细胞纤维化
Xinchen Huang,Xiaoling Kui,Jiyao Ma et al.
Xinchen Huang et al.
Sarcopenia is characterized by age-related muscle mass/function loss and fibrosis. Satellite cell (SC) dysfunction during aging promotes fibrotic transdifferentiation and extracellular matrix (ECM) deposition. Cyr61, a pro-fibrotic matricel...
Jitendra Kumar Chaudhary,Ajay Kumar Danga,Anita Kumari et al.
Jitendra Kumar Chaudhary et al.
Stem cell functions and ageing are deeply interconnected, continually influencing each other in multiple ways. Stem cells play a vital role in organ maintenance, regeneration, and homeostasis, all of which decline over time due to gradual r...
Transcriptomic and Epigenomic Signatures of Liver Metabolism and Insulin Sensitivity in Aging Mice [0.03%]
小鼠衰老过程中肝脏代谢和胰岛素敏感性的转录组和表观基因组特征
John T González,Olivia H Scharfman,Wanling Zhu et al.
John T González et al.
Age-related declines in insulin sensitivity and glucose metabolism contribute to metabolic disease. Despite the liver's central role in glucose homeostasis, a comprehensive phenotypic characterization and concurrent molecular analysis of in...