Mechanism of FTO-Mediated m6A Demethylation Regulation of YAP1 in Nucleus Pulposus Cell Senescence [0.03%]
FTO介导的YAP1去甲基化调节机制促进椎间盘软骨终板细胞衰老
Rui Sun,Xiao-Tao Wu,Hang Shi et al.
Rui Sun et al.
Nucleus pulposus (NP) cell senescence is a critical factor in the progression of intervertebral disc degeneration (IVDD). Our analysis demonstrates that FTO and YAP1 expression levels are significantly diminished in degenerative NP tissues ...
Electrical Brain Activity in Centenarians: Neurophysiological EEG Markers in resilient brain Ageing [0.03%]
百岁老人的脑电活动：弹性脑衰老的神经生理EEG标志物研究
Fabrizio Vecchio,Chiara Pappalettera,Alessia Cacciotti et al.
Fabrizio Vecchio et al.
Centenarians are an increasing population, in particular in high income countries. Studying cognitively intact Centenarians' brain becomes fundamental to understand physiological ageing and how it diverges from pathological one. Resting sta...
Circulating microRNAs and cross sectional and longitudinal measurements of physical functioning and frailty: an explorative study in older twins [0.03%]
循环microRNA与老年人身体功能的横断面和纵向测量：一项在老年双胞胎中的探索性研究
Rossella La Grotta,Cecilie Agergaard Sørensen,Asmus Cosmos Skovgaard et al.
Rossella La Grotta et al.
During aging, physical functioning declines, and disability and frailty increase; phenotypes which are bidirectionally linked. MicroRNAs (miRNAs) are epigenetic regulators of various physiological processes and suggested aging biomarkers. H...
Genome-Wide RNAi Analysis in Adult Caenorhabditis elegans Unveils Genes Controlling Age-Related Fat Accumulation [0.03%]
基于成体秀丽隐杆线虫的全基因组RNAi分析发现控制衰老相关脂肪蓄积的基因
Chunxia Qin,Zicheng Liu,Duo Duan et al.
Chunxia Qin et al.
Fat accumulation with aging occurs in adults across species, yet its mechanisms remain poorly understood, partly due to limited studies focused specifically targeting adulthood. Here, we present the first genome-wide analysis of age-associa...
Energetic cost of biosynthesis modulates the growth-longevity tradeoff in mice: Quantitative insights into four lifespan-altering manipulations [0.03%]
生命能量消耗成本调节了小鼠生长与寿命的权衡关系——四种延长寿命方法的量化研究新进展
Chen Hou,Fahimeh Taheri
Chen Hou
Life history theory proposes a tradeoff between growth rate and lifespan, typically explained by the allocation of limited energy resources between somatic growth and maintenance. However, this explanation does not give a complete picture o...
The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs [0.03%]
非洲蓝彩燕鱼（诺托布拉奇乌斯-富泽里）：多器官衰老相关疾病和再生能力衰退的模型
Takayoshi Otsuka,Hideaki Matsui
Takayoshi Otsuka
African turquoise killifish (Nothobranchius furzeri) has emerged as a promising vertebrate model for aging research because of its unique characteristics. Its exceptionally short lifespan and rapid aging make it an ideal model for studying ...
Galectin-3-binding protein is a risk factor for Diabetes, Metabolic Syndrome, and Inflammation. Cross-sectional and Longitudinal Results from the InCHIANTI study [0.03%]
半乳糖凝集素-3结合蛋白是糖尿病、代谢综合征及炎症的危险因素。来自InCHIANTI研究横断面和前瞻性证据
Raffaello Pellegrino,David Perpetuini,Roberto Paganelli et al.
Raffaello Pellegrino et al.
Galectin-3-binding protein (Lgals3bp), a heavily glycosylated protein that plays a role in cell growth, inflammation, and cellular adhesion, has been associated with tumor development and more recently with carbohydrate and lipid metabolism...
Corrigendum to "Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population" [Mech. Ageing Dev. 225 (2025) 112043] [0.03%]
“巨细胞病毒血清状态与ELOVL2甲基化的关系：对MARK-AGE研究人群脂质代谢、炎症、DNA损伤和修复能力的影响”一文中表观遗传学部分的勘误[《机械老化与发展》第225卷(2025年)112043页]
Robertina Giacconi,Chiara Pirazzini,Maria Giulia Bacalini et al.
Robertina Giacconi et al.
Published Erratum
Mechanisms of ageing and development. 2025 Jun 26:112085. DOI:10.1016/j.mad.2025.112085 2025
Abhishek Chandra,Robert J Pignolo
Abhishek Chandra
Functional significance of extracellular vesicles as mediators of cardiometabolic and cardiorenal diseases upon aging [0.03%]
外泌体在衰老过程中介导心血管-代谢和心血管-肾脏疾病的功能意义
Wing Yan Chung,Sabrina Lam,Brooke Pernari et al.
Wing Yan Chung et al.
Aging increases the risk of cardiometabolic and cardiorenal disease and this is associated with cellular dysregulation including oxidative stress, chronic inflammation, insulin resistance and senescence. Extracellular vesicles (EV) facilita...