Cell-specific energy crisis in the ageing brain: Mitochondrial dynamics drives neuron-glia metabolic uncoupling and neurodegeneration [0.03%]
衰老大脑中的细胞特异性能量危机：线粒体动力学驱动神经胶质代谢脱耦和神经退行性病变
Kai Wang,Yongchao Liu,Haojia Zhang et al.
Kai Wang et al.
Ageing is the primary risk factor for neurodegeneration and age-related cognitive decline, which is increasingly recognised as a systemic collapse of metabolic crosstalk between neurons and glial cells in the brain. This narrative review el...
The epigenetic control of inflammaging in skeletal muscle and adipose tissue [0.03%]
骨骼肌和脂肪组织中表观遗传调控的炎症衰老
Diego Gomes de Melo,Vivian Cristina da Cruz Rodrigues,Gustavo José de Sá Pereira et al.
Diego Gomes de Melo et al.
Metabolic inflexibility, mitochondrial dysfunction, and persistent low-grade inflammation are recognized as fundamental hallmarks of biological ageing and key drivers of the inflammaging process. Ageing is associated with a progressive decl...
Sage (Salvia spp.) as a multi-target resource for healthy aging: Current evidence and perspectives [0.03%]
sage（Salvia spp.）在健康老龄化中作为多靶标资源的现状及展望
Isabella Giacomini,Miles Sarill,Veronica Cocetta et al.
Isabella Giacomini et al.
Aging is driven by interacting processes, including oxidative stress, chronic low-grade inflammation, cellular senescence, and dysregulated tissue remodeling. Salvia (sage) is the largest genus in the Lamiaceae and is widely used in traditi...
Expression of Concern to "CHIP E3 ligase regulates mammalian senescence by modulating the levels of oxidized proteins" [Mech. Ageing Dev. 132 (2011) 269-272] [0.03%]
关于《CHIP E3连接酶通过调节氧化蛋白的水平调控哺乳动物衰老》的观点表达[ Mechanisms of Ageing and Development, 132 (2011) 269-272 ]
Christina Sisoula,Efstathios S Gonos
Christina Sisoula
Pro-Xylane alleviates ultraviolet-induced skin senescence through SGK1-mediated p21 ubiquitination and subcellular translocation [0.03%]
脯氢胺醇通过SGK1介导的p21泛素化和亚细胞定位改变缓解紫外线引起的皮肤衰老
Tingting Wang,Nan Huang,Xiaofang Zhang et al.
Tingting Wang et al.
Background: Ultraviolet B (UVB) radiation causes skin damage, leading to aging and inflammatory responses. Pro-Xylane, a plant-derived compound, has been proposed for its potential protective effects against UVB-induced s...
Biological aging as a mediator of the association between air pollution and all-cause mortality and hospitalization: Evidence from the UK Biobank and Lifelines cohorts [0.03%]
空气污染与全因死亡率和住院率之间关系的老化介导效应：英国生物银行队列和Lifelines队列的证据
Parinaz Poursafa,Esha Khan,Jonathan K L Mak et al.
Parinaz Poursafa et al.
Air pollution is a major environmental risk factor for premature mortality and hospitalization, yet the biological pathways linking pollution exposure to disease and mortality remain incompletely understood. We investigated whether biologic...
Rui Wang,Chen Liang,Yaqian Li et al.
Rui Wang et al.
Rising global life expectancy intensifies the health impact of female lower reproductive tract aging, particularly affecting the uterus, cervix, and vagina. This process is primarily driven by estrogen depletion triggering hormonal imbalanc...
Targeting DYRK1A with Harmine Abrogates the FOXO1-NF-κB Axis to Alleviate Cellular Senescence and Renal Fibrosis [0.03%]
靶向DYRK1A的 harmine 通过消除FOXO1-NF-κB轴来缓解细胞衰老和肾纤维化
Pengfei Qiao,Yixuan Zhu,Junming Zhang et al.
Pengfei Qiao et al.
Proximal renal tubule epithelial cell (TEC) senescence and its associated senescence-associated secretory phenotype (SASP) drive renal fibrosis, yet the underlying molecular mechanism remains elusive. Dual-specificity tyrosine phosphorylati...
Mitochondria-lysosome contacts in aging: A mechanistic interface linking organelle homeostasis and cellular decline [0.03%]
衰老中的线粒体溶酶体接触：连接细胞器稳态和细胞功能衰退的机制接口
YiFan Yan,Yuetong Li,Heng Ma
YiFan Yan
Mitochondria-lysosome contacts (MLCs) are emerging as a dynamic membrane interface that integrates organelle communication with cellular homeostasis. Rather than acting solely as intermediates of degradative trafficking, MLCs organize local...
Circulating miR-483-5p predicts long term all-cause mortality in hospitalized older adults [0.03%]
循环miR-483-5p预测住院老年患者的长期全因死亡率
Silvia Di Valerio,Deborah Ramini,Matilde Sbriscia et al.
Silvia Di Valerio et al.
Accurately predicting long-term mortality in older adults remains challenging, as chronological age and conventional clinical indices incompletely capture biological vulnerability. Circulating microRNAs (miRNAs) have emerged as potential bi...