Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson' s disease cohorts [0.03%]
中国大型帕金森病队列中磷脂酶A2超基因家族的全面变异分析
Jiabin Liu,Yige Wang,Yuwen Zhao et al.
Jiabin Liu et al.
To clarify the genetic role of phospholipase A2 (PLA2) genes in Parkinson's disease (PD), we performed a genetic association study in large Chinese population cohorts using next-generation sequencing. In this study, we analyzed both rare an...
Sarcopenia: A dive into metabolism to promote a multimodal, preventive, and regenerative approach [0.03%]
sarcopenia：从代谢角度出发，促进多模式、预防和再生治疗方法的研究
Virginia Boccardi
Virginia Boccardi
Sarcopenia, the age-related loss of skeletal muscle mass and function, poses a significant challenge in the field of geriatrics and gerontology, impacting the health and independence of older adults. Understanding and addressing sarcopenia ...
Inflammaging score as a potential prognostic tool for cancer: A population-based cohort study [0.03%]
基于人群的队列研究中炎症衰老评分作为癌症预后工具的潜力
Hailun Xie,Lishuang Wei,Guotian Ruan et al.
Hailun Xie et al.
This study aimed to develop a clinically applicable inflammaging score by combining the inflammatory status and age of patients. Kaplan-Meier analysis was used to compare survival differences among patients with different grades of inflamma...
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites [0.03%]
白桦脂醇通过抑制肝毒性代谢产物诱导的衰老微环境从而保护HepG2细胞免于衰老
Neda Heidari,Susan Sandeman,Marcus Dymond et al.
Neda Heidari et al.
Progressive liver disease and dysfunction cause toxic metabolites including ammonia and unconjugated bilirubin to accumulate in plasma. As the population ages alternatives to liver transplantation become increasingly important. One approach...
Retraction notice to "A feasibility study of the combination of intranasal insulin with dulaglutide for cognition in older adults with metabolic syndrome at high dementia risk- Study rationale and design" [Mech. Ageing Dev. 213 (2023) 111825] [0.03%]
撤稿通知：“针对高痴呆风险代谢综合征老年人的认知，鼻用胰岛素与杜拉鲁肽联合使用的可行性研究——研究理由和设计”[ Mechanisms of Ageing and Development 213 (2023) 111825]
Tal Davidy,Iscka Yore,Tali Cukierman-Yaffe et al.
Tal Davidy et al.
Retraction of Publication
Mechanisms of ageing and development. 2024 Jun:219:111937. DOI:10.1016/j.mad.2024.111937 2024
SuperAgers and centenarians, dynamics of healthy ageing with cognitive resilience [0.03%]
超级老人与百岁老人：具有认知弹性的健康老龄化动力学
Md Ariful Islam,Ujala Sehar,Omme Fatema Sultana et al.
Md Ariful Islam et al.
Graceful healthy ageing and extended longevity is the most desired goal for human race. The process of ageing is inevitable and has a profound impact on the gradual deterioration of our physiology and health since it triggers the onset of m...
Effect of in vivo culture conditions on the proliferation and differentiation of rat adipose-derived stromal cells [0.03%]
培养条件对大鼠脂肪来源stromal细胞增殖及分化的影响
Chao Wang,Tian Xie,Xiaoming Li et al.
Chao Wang et al.
Adipose-derived stromal cells (ADSCs) are promising stem cell sources for tissue engineering and cell-based therapy. However, long-term in vitro expansion of ADSCs impedes stemness maintenance, which is partly attributed to deprivation of t...
Plasma cfDNA abundance as a prognostic biomarker for higher risk of death in geriatric cardiovascular patients [0.03%]
血浆cfDNA丰度作为老年心血管疾病患者死亡风险的预后生物标志物
Maurizio Cardelli,Francesca Marchegiani,Pierpaolo Stripoli et al.
Maurizio Cardelli et al.
The management of geriatric cardiovascular disease (CVD) patients with multimorbidity remains challenging and could potentially be improved by integrating clinical data with innovative prognostic biomarkers. In this context, the analysis of...
Impact of Seipin in cholesterol mediated lipid droplet maturation; status of endoplasmic reticulum stress and lipophagy [0.03%]
硒蛋白在胆固醇介导的脂滴成熟中的作用；内质网应激和脂自噬的状态
Tugce Demirel-Yalciner,Bengu Cetinkaya,Erdi Sozen et al.
Tugce Demirel-Yalciner et al.
The global prevalence of nonalcoholic fatty liver disease (NAFLD) defined by the increased number of lipid droplets (LDs) in hepatocytes, have risen continuously in parallel with the obesity. LDs and related proteins are known to affect cel...
Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4 [0.03%]
肾脂质积累和衰老通过ANGPTL4与管状细胞损伤相关联
Xiaojun Wang,Hung-Chen Chang,Xuchao Gu et al.
Xiaojun Wang et al.
Renal tubular epithelial cells are vulnerable to stress-induced damage, including excessive lipid accumulation and aging, with ANGPTL4 potentially playing a crucial bridging role between these factors. In this study, RNA-sequencing was used...