Quercetin induces senolysis of doxorubicin-induced senescent fibroblasts by reducing autophagy, preventing their pro-tumour effect on osteosarcoma cells [0.03%]
槲皮素通过减少自噬诱导多柔比星诱导的成纤维细胞的衰老消除作用，防止其对骨肉瘤细胞产生促肿瘤效应
Elisa Bientinesi,Sara Ristori,Matteo Lulli et al.
Elisa Bientinesi et al.
Cellular senescence contributes to ageing and age-related diseases, and multiple therapeutic strategies are being developed to counteract it. Senolytic drugs are being tested in clinical trials to eliminate senescent cells selectively, but ...
Exploring the interplay between stress mediators and skin microbiota in shaping age-related hallmarks: A review [0.03%]
应激介导物和皮肤微生物群在塑造年龄相关标志特征中的相互作用：综述式的评论文章
Marco Duarte,Sílvia Santos Pedrosa,P Raaj Khusial et al.
Marco Duarte et al.
Psychological stress is a major contributing factor to several health problems (e.g., depression, cardiovascular disease). Around 35 % of the world's population suffers from it, including younger generations. Physiologically, stress manifes...
Time-dependent effects of high-fat diet on cognition and cerebral insulin signaling: Window for recovery and potential therapeutic target [0.03%]
高脂饮食对认知和脑内胰岛素信号时间依赖性影响：恢复窗口及潜在治疗靶点
Tianchuang Zhao,Qi Li,Xiaodan Wang et al.
Tianchuang Zhao et al.
While high-fat diet (HFD)-induced obesity is a major threat to global public health, the effect of HFD on cognition and insulin signaling during ageing remains controversial. The aim of this study was to characterize the dynamic alterations...
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application? [0.03%]
CAR、mGPS和hs-mGPS：哪个是与年龄相关疾病最相关的超级生物标志物？应用于何处？
Miriam Carella,Daniele Magro,Letizia Scola et al.
Miriam Carella et al.
The identification of biomarkers linked to the onset, progression, and prevention of age-related diseases (ARD), in the era of personalized medicine, represents the best goal of geroscience. Geroscience has the fundamental role of exploring...
Competing endogenous RNA networks were associated with fat accumulation in skeletal muscle of aged male mice [0.03%]
竞争性内源RNA网络与老年小鼠骨骼肌脂肪蓄积相关性分析
Yuxiao Liao,Zhao Peng,Xiaolei Zhou et al.
Yuxiao Liao et al.
Muscle aging contributed to morbidity and mortality in the elderly adults by leading to severe outcomes such as frailty, falls and fractures. Post-transcriptional regulation especially competing endogenous RNA (ceRNA) mechanism may modulate...
The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop [0.03%]
HNF1a-免疫信号环路调节胰岛细胞系谱的年龄相关重塑以促进胰腺功能老化
Andreas Frøslev Mathisen,Thomas Aga Legøy,Ulrik Larsen et al.
Andreas Frøslev Mathisen et al.
Animal longevity is a function of global vital organ functionality and, consequently, a complex polygenic trait. Yet, monogenic regulators controlling overall or organ-specific ageing exist, owing their conservation to their function in gro...
Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus [0.03%]
脑室旁下丘脑局部大麻素受体1型调节小胶质细胞活性和胰岛素样生长因子1受体信号转导
Michela Palmisano,Carla Florencia Ramunno,Eli Farhat et al.
Michela Palmisano et al.
As organisms age, the activity of the endocannabinoid system in the brain declines, coinciding with increased neuroinflammation and disrupted hypothalamic functions. Notably, cannabinoid receptors type-1 (CB1) are highly expressed in the ve...
Elucidating the role of chemokines in inflammaging associated atherosclerotic cardiovascular diseases [0.03%]
阐明趋化因子在与衰老相关动脉粥样硬化心血管疾病中的作用
Nupur Nagar,Goutami Naidu,Santosh Kumar Panda et al.
Nupur Nagar et al.
Age-related inflammation or inflammaging is a critical deciding factor of physiological homeostasis during aging. Cardiovascular diseases (CVDs) are exquisitely associated with aging and inflammation and are one of the leading causes of hig...
Understanding the (epi)genetic dysregulation in Parkinson's disease through an integrative brain competitive endogenous RNA network [0.03%]
通过整合的脑竞争性内源RNA网络理解帕金森病中的（表观）基因调控失调
Rafael Mina Piergiorge,Ana Tereza Ribeiro de Vasconcelos,Cíntia Barros Santos-Rebouças
Rafael Mina Piergiorge
Parkinson's disease (PD) is a rapidly growing neurodegenerative disorder characterized by dopaminergic neuron loss in the substantia nigra pars compacta (SN) and aggregation of α-synuclein. Its aetiology involves a multifaceted interplay a...
Iliyana Sazdova,Nikola Hadzi-Petrushev,Milena Keremidarska-Markova et al.
Iliyana Sazdova et al.
This review focuses on the vital function that SIRT1 and other sirtuins play in promoting cellular senescence in vascular smooth muscle cells, which is a key element in the pathogenesis of vascular aging and associated cardiovascular diseas...