Effect of age and latent CMV infection on CD8+ CD56+ T cells (NKT-like) frequency and functionality [0.03%]
年龄和潜伏性CMV感染对CD8+CD56+NKT样T细胞频率和功能的影响
Fakhri Hassouneh,Carmen Campos,Nelson López-Sejas et al.
Fakhri Hassouneh et al.
Changes in the T cell pool caused by CMV infection have been proposed to contribute to immunosenescence, but it has been postulated that CMV can also have some beneficial effects in young individuals improving the immune response to other p...
Inhibition of senescence and promotion of the proliferation of chondrocytes from articular cartilage by CsA and FK506 involves inhibition of p38MAPK [0.03%]
环孢素和他克莫司通过抑制p38MAPK途径延缓骨关节软骨细胞衰老并促进其增殖
Seok-Won Kang,Jungbin Kim,Deug Y Shin
Seok-Won Kang
Cyclosporine A (CsA) and tacrolimus (FK506) are the most important immunosuppressive compounds that block the activation of helper T-cells. In this study, we investigated the effects of CsA and FK506 on growth and senescence of articular ch...
Glutathione S-transferase mediates an ageing response to mitochondrial dysfunction [0.03%]
谷胱甘肽S-转移酶介导了对线粒体功能障碍的衰老反应
Beverley M Dancy,Nicole Brockway,Renjini Ramadasan-Nair et al.
Beverley M Dancy et al.
To understand primary mitochondrial disease, we utilized a complex I-deficient Caenorhabditis elegans mutant, gas-1. These animals strongly upregulate the expression of gst-14 (encoding a glutathione S-transferase). Knockdown of gst-14 dram...
David Houghton,Thomas W Jones,Sophie Cassidy et al.
David Houghton et al.
Age-related changes in cardiac and vascular function are associated with increased risk of cardiovascular mortality and morbidity. The aim of the present study was to define the effect of age on the relationship between cardiac and vascular...
Psychological stress-induced catecholamines accelerates cutaneous aging in mice [0.03%]
心理应激源肾上腺素促进小鼠皮肤老化现象
Bruna Romana-Souza,Gracineide Santos Lima-Cezar,Andréa Monte-Alto-Costa
Bruna Romana-Souza
Psychological stress may be an important extrinsic factor which influences aging process. However, neither study demonstrated the mechanism by which chronic stress participates in skin aging. Aim of this study was to investigate the effects...
Age-dependent alterations of voltage-gated Na(+) channel isoforms in rat sinoatrial node [0.03%]
大鼠窦房结电压门控钠通道随年龄的变化
Xin Huang,Yuan Du,Pei Yang et al.
Xin Huang et al.
Multiple isoforms of voltage-gated Na(+) channels (NaChs) have been identified in sinoatrial node (SAN) and contribute to a rapid intrinsic heart rate. However, their roles in aging remain unclear. Here, we sought to clarify whether the age...
Telomere length is not associated with frailty in older Chinese elderly: Cross-sectional and longitudinal analysis [0.03%]
端粒长度与老年人衰弱无关：横断面及纵向分析
Ruby Yu,Nelson Tang,Jason Leung et al.
Ruby Yu et al.
Telomere shortening has been associated with biological age and several chronic degenerative diseases. However, less is known about telomere length and frailty, which is an indicator of biological age. This study examines the association be...
Hyperphosphatemia induces cellular senescence in human aorta smooth muscle cells through integrin linked kinase (ILK) up-regulation [0.03%]
血磷升高通过整合素连接激酶(_ILK_)上调诱导人主动脉平滑肌细胞衰老进入复制性衰老停滞状态
Nuria Troyano,María Del Nogal,Inés Mora et al.
Nuria Troyano et al.
Aging is conditioned by genetic and environmental factors. Hyperphosphatemia is related to some pathologies, affecting to vascular cells behavior. This work analyze whether high concentration of extracellular phosphate induces vascular smoo...
Stuart J Bennett,Edyta M Augustyniak,Christopher R Dunston et al.
Stuart J Bennett et al.
To identify novel cell ageing markers in order to gain insight into ageing mechanisms, we adopted membrane enrichment and comparison of the CD4(+) T cell membrane proteome (purified by cell surface labelling using Sulfo-NHS-SS-Biotin reagen...
Fivos Borbolis,Popi Syntichaki
Fivos Borbolis
Messenger RNA (mRNA) turnover that determines the lifetime of cytoplasmic mRNAs is a means to control gene expression under both normal and stress conditions, whereas its impact on ageing and age-related disorders has just become evident. G...