The relationship between physical activity and telomere length in women: A systematic review [0.03%]
体力活动和女性端粒长度的关系：系统回顾
Jeni Page,Catherine Stephens,Melissa Richard et al.
Jeni Page et al.
Telomere length (TL) is a biomarker of cellular aging with variations observed by sex, age, race, and ethnicity. Prior studies have suggested that physical activity (PA) may positively impact TL by potentially elongating telomeres and slowi...
Vascular Participation in Bone Healing: Implications Related to Advancing Age and Morbidity [0.03%]
血管在骨愈合中的作用：与年龄增大和疾病的关联影响
Rhonda D Prisby
Rhonda D Prisby
Fracture non-union and the related morbidities represent a global health concern. While many factors are necessary for proper bone healing following fracture, the vascular system is requisite. Important considerations include vascular morph...
Aging: a Struggle for Beneficial to Overcome Negative Factors made by Muscle and Bone [0.03%]
衰老：一场克服肌肉和骨骼带来的负面影响的有益斗争
Steven S Welc,Marco Brotto,Kenneth E White et al.
Steven S Welc et al.
Musculoskeletal health is strongly influenced by regulatory interactions of bone and muscle. Recent discoveries have identified a number of key mechanisms through which soluble factors released during exercise by bone exert positive effects...
The EZH2/MCM Complex/hTERT axis facilitates hepatocellular carcinoma progression by inhibiting cellular senescence [0.03%]
EZH2/MCM复合体/hTERT轴通过抑制细胞衰老促进肝癌进展
Ziyi Shen,Yuanhui Wang,Jie Gao et al.
Ziyi Shen et al.
The complex pathogenesis of hepatocellular carcinoma (HCC) limits the effectiveness of current therapies. Through RNA sequencing of cancerous and adjacent non-cancerous tissues from six HCC patients, we identified a significant upregulation...
Mangiferin Protects Mesenchymal Stem Cells Against DNA Damage and Cellular Aging via SIRT1 Activation [0.03%]
mango glycoside mangiferin通过激活SIRT1保护间充质干细胞免受DNA损伤和细胞衰老的影响
Gyeong Min Lim,Gwang-Won Cho
Gyeong Min Lim
The protective effects of mangiferin (MAG) against etoposide- and high glucose (HG)-induced DNA damage and aging were investigated in human bone marrow-mesenchymal stem cells (hBM-MSCs). Etoposide, a topoisomerase II inhibitor, was used to ...
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses [0.03%]
老龄肺泡上皮细胞中的IRF1-RIGI信号缺陷可能导致抗病毒免疫反应下降
Shan Li,Qianqian Lu,Jiao Lu et al.
Shan Li et al.
Background: Alveolar epithelial cells (AECs) are the primary targets of many pathogens and play an important role in sensing viruses and regulating immunity. Yet, little is known about the antiviral responses in the aged ...
Deciphering the role of cytokines in aging: biomarker potential and effective targeting [0.03%]
细胞因子在衰老中的作用解析：生物标志物潜力和有效靶向
Panagiotis Poulios,Stamoulis Skampouras,Christina Piperi
Panagiotis Poulios
Aging is often characterized by chronic inflammation, immune system dysregulation, and cellular senescence with chronically elevated levels of pro-inflammatory cytokines. These small glycoproteins are mainly secreted by immune cells, mediat...
Corrigendum to "Characterization of a natural model of adult mice with different rate of aging" [Mech. Ageing Dev. 222 (2024), 111991] [0.03%]
“具有不同衰老速率的成年小鼠自然模型特征”一文的勘误(机械年龄发展第222卷(2024)页111991)
Judith Félix,Estefanía Díaz-Del Cerro,Antonio Garrido et al.
Judith Félix et al.
Published Erratum
Mechanisms of ageing and development. 2025 Jan 17:112027. DOI:10.1016/j.mad.2025.112027 2025
Ivana Lansweers,Sharon van Rijthoven,Jack J W A van Loon
Ivana Lansweers
The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex plays a crucial role in connecting the nuclear envelope to the cytoskeleton, providing structural support to the nucleus and facilitating mechanical signaling between the extracel...
The effect of Torque Teno Virus (TTV) Infection on Clinical Outcomes, Genomic Integrity, and Mortality in COPD Patients [0.03%]
TT病毒感染对慢性阻塞性肺疾病患者临床结局、基因组完整性和死亡率的影响
Patrizia Russo,Francesca Milani,Dolores Limongi et al.
Patrizia Russo et al.
Introduction: Torque Teno Virus (TTV), an "orphan" virus with unclear pathology, has been associated with various diseases and immune dysfunctions. This study investigates the link between TTV viremia and clinical markers...