Plasma metabolomic profiles reveal sex-specific response to an oral glucose tolerance test in late middle-aged adults [0.03%]
基于血浆代谢组揭示口服葡萄糖耐量试验在中年成人中的性别差异响应
C M Donado-Pestana,L Rodrigues,M Rundle et al.
C M Donado-Pestana et al.
Sex is a key determinant of human phenotype, with males and females exhibiting distinct anthropometric and metabolic features that influence disease susceptibility. This study investigated sex-specific metabolic differences in late middle-a...
Interspecific interactions and aging: Prediction of gerogenic bacteria and critical human protein targets of microbial infections [0.03%]
种间互作与衰老：预测致龄细菌及微生物感染的人源蛋白关键靶标
Yuping Dai,Ni Boussaguet,Jérôme Teulière et al.
Yuping Dai et al.
Bacteria permeate every niche of the human body with major consequences on our health and senescence that have not been fully described. Here, we predict which bacteria and which bacterial proteins could interfere with proteins associated w...
Cyr61 Promotes D-gal-induced Aging C2C12 Cell Fibrosis by Modulating Wnt/β-catenin Signaling Pathways [0.03%]
Cyr61通过调节Wnt/β-catenin信号通路促进D-半乳糖诱导的C2C12细胞纤维化
Xinchen Huang,Xiaoling Kui,Jiyao Ma et al.
Xinchen Huang et al.
Sarcopenia is characterized by age-related muscle mass/function loss and fibrosis. Satellite cell (SC) dysfunction during aging promotes fibrotic transdifferentiation and extracellular matrix (ECM) deposition. Cyr61, a pro-fibrotic matricel...
Jitendra Kumar Chaudhary,Ajay Kumar Danga,Anita Kumari et al.
Jitendra Kumar Chaudhary et al.
Stem cell functions and ageing are deeply interconnected, continually influencing each other in multiple ways. Stem cells play a vital role in organ maintenance, regeneration, and homeostasis, all of which decline over time due to gradual r...
Transcriptomic and Epigenomic Signatures of Liver Metabolism and Insulin Sensitivity in Aging Mice [0.03%]
小鼠衰老过程中肝脏代谢和胰岛素敏感性的转录组和表观基因组特征
John T González,Olivia H Scharfman,Wanling Zhu et al.
John T González et al.
Age-related declines in insulin sensitivity and glucose metabolism contribute to metabolic disease. Despite the liver's central role in glucose homeostasis, a comprehensive phenotypic characterization and concurrent molecular analysis of in...
HRasV12 induces apoptosis, not cellular senescence in mouse skeletal myoblasts [0.03%]
HRasV12诱导小鼠骨骼肌母细胞凋亡而非细胞衰老现象
Shinichiro Suzuki,Takuya Fukunaga,Tatsuya Hayashi et al.
Shinichiro Suzuki et al.
Aging is a key risk factor for sarcopenia, a progressive disorder affecting skeletal muscle. One hallmark of aging is cellular senescence. To investigate cellular senescence in mouse skeletal myoblasts, we attempted to induce cellular senes...
Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3 [0.03%]
亨廷顿病MJD/SCA3动物模型寿命延长的遗传操作的不同效应
Marta Daniela Costa,Jorge Diogo Da Silva,Dulce Almeida et al.
Marta Daniela Costa et al.
Aging is a natural biological process, but evidence suggests that some aspects of aging can be delayed and reduce the prevalence of neurodegenerative diseases, for which aging is a key risk factor. In a neuronal Caenorhabditis elegans model...
KAEMPFEROL, A WIDELY INGESTED DIETARY FLAVONOID AND SUPPLEMENT, ENHANCES BIOLOGICAL PERFORMANCE VIA HORMESIS, ESPECIALLY FOR AGEING-RELATED PROCESSES [0.03%]
番石榴素通过激素作用尤其是与衰老相关的机制增强生物性能
Edward J Calabrese,Peter Pressman,A Wallace Hayes et al.
Edward J Calabrese et al.
Kaempferol is a polyphenol in various fruits and vegetables. It is also commercially developed and sold to consumers as a supplement. It has been extensively assessed in clinical trials for clinical utility based upon its numerous experimen...
Actinomyces viscosus promotes neuroprotection in C. elegans models of Parkinson's disease [0.03%]
黏液类芽胞杆菌促进帕金森病线虫模型中的神经保护作用
G Sophie Ngana,Mercedes A Di Bernardo,Michael G Surette et al.
G Sophie Ngana et al.
Parkinson's Disease is characterized by selective degeneration of dopaminergic neurons, primarily in the substantia nigra pars compacta, as well as accumulation of alpha-synuclein enriched protein aggregates within neurons. The pathogenesis...
miR-132-3p is down-regulated in plasma and CD171+ extracellular vesicles isolated from patients with mild Alzheimer's disease [0.03%]
血浆和CD171+细胞外囊泡中的miR-132-3p在轻度阿尔茨海默病患者中下调
Matilde Sbriscia,Tatiana Spadoni,Patrizia Ambrogini et al.
Matilde Sbriscia et al.
Alzheimer's disease (AD), the most prevalent neurodegenerative disorder in aging populations, demands minimally invasive biomarkers for early diagnosis and monitoring. Circulating microRNAs (miRNAs) show promise as such biomarkers. In this ...