Current Status of PSMA-Targeted Agents Based on Small Molecules for Prostate Cancer in Preclinical Studies [0.03%]
基于小分子的PSMA靶向前列腺癌药物的临床前研究现状
Ayman Muzammal,Kyo Chul Lee,Sairan Eom
Ayman Muzammal
Prostate-specific membrane antigen (PSMA) has emerged as a clinically validated target for the diagnosis and treatment of prostate cancer using radioligand therapy (RLT). Among various PSMA-targeting ligands, urea-based small-molecules have...
Fibroblast Activation Protein-Targeted SPECT Imaging Using 99mTc: A Comprehensive Review [0.03%]
99mTc标记的成纤维细胞活化蛋白靶向SPECT显像综合述评
Aisha Yasin,Syed Ali Raza Naqvi,Shakaib Arslan Gursal et al.
Aisha Yasin et al.
Fibroblast activation protein (FAP) is a type II transmembrane serine protease that is highly expressed in cancer-associated fibroblasts in the tumor microenvironment of over 90% of epithelial malignancies, and is largely absent in normal t...
Feasibility of [99mTc]Tc-Mannosylated Human Serum Albumin for Lymphoscintigraphy: A Phase 1/2 Clinical Trial [0.03%]
一项一期/二期临床试验：用99mTc-甘露糖人血清白蛋白进行淋巴造影的可行性研究
Hyunpil Sung,Minseok Suh,Hyun Gee Ryoo et al.
Hyunpil Sung et al.
Purpose: Lymphoscintigraphy is crucial for diagnosis of lymphatic abnormality and sentinel lymph node (SLN) detection in surgery. We investigated the feasibility of [99mTc]Tc-mannosylated human serum albumin (MSA) as a ne...
Automated Synthesis of Radiopharmaceuticals: Technology, Applications, and Regulatory Perspectives [0.03%]
放射药物的自动化合成：技术、应用与监管观点
Nare Ko,Sang Ju Lee,Seung Jun Oh
Nare Ko
The automatic synthesis of radiopharmaceuticals has a long history, from [18F]FDG to the most recent metallic radioisotope-labeled radiopharmaceuticals. Initially, the development of the automatic synthesis process focused on radioisotope l...
Development of Antibody and Antibody Fragment-Based Radiopharmaceuticals for Cancer Imaging and Therapy [0.03%]
基于抗体及抗体片段的癌症诊疗放射性药物研发进展
Chi Soo Kang
Chi Soo Kang
Cancer has been the leading cause of death and imposing tremendous socioeconomical pressure worldwide. It is considered the most difficult disease to tackle and major obstacle for extending life expectancy. Radiopharmaceuticals in the field...
Personalised Dosimetry in Nuclear Medicine: Bridging Physics, Biology and AI for Next Generation Radiopharmaceutical Therapy [0.03%]
核医学中的个性化剂量学：物理、生物与人工智能在下一代放射药物治疗中的融合与发展
Joycie Shanmugiah,Jin Su Kim
Joycie Shanmugiah
Radiopharmaceutical dosimetry is rapidly evolving from a physics-dominated calculation tool to a central pillar of precision nuclear medicine. As targeted radionuclide therapies expand across indications, there is a growing clinical imperat...
Optimizing 131I-mIBG Dosimetry: Validation of Simplified Time-Point and Segmentation Approaches [0.03%]
优化¹³¹I-mIBG剂量学：简化时间点和分割方法的验证
Sara Kurkowska,Małgorzata Poniatowska,Carlos Uribe et al.
Sara Kurkowska et al.
Purpose: To evaluate simplified dosimetry methods for 131I-mIBG therapy that maintain agreement with reference method while reducing clinical workflow burdens, particularly beneficial for pediatric applications. ...
Muhammad Zeeshan,Huu Bao Nguyen,Jeongsoo Yoo
Muhammad Zeeshan
Radioimmunoconjugates, formed by attaching radionuclides to monoclonal antibodies (mAbs) either directly or through bifunctional chelators, have advanced precision oncology by enabling targeted molecular imaging and therapy. Copper radioiso...
Optimizing [99mTc]Tc-Tamsulosin for Enhanced Tumor Detection: A Comprehensive Approach from Preparation to In Vivo Evaluation [0.03%]
优化[99mTc]Tc-坦索罗辛以增强肿瘤检测：从制备到体内评价的全面方法
M H Sanad,Safaa B Challan,A Massoud
M H Sanad
Purpose: To investigate the potential of Tamsulosin hydrochloride, a selective α1-adrenoceptor antagonist, as a tumor-targeting ligand when labeled with Technetium-99 m [⁹⁹ᵐTc] for use as a novel radiopharmaceutical. ...