Targeting intratumoral Streptococcus mitis suppresses the progression of esophageal squamous cell carcinoma [0.03%]
靶向食管鳞癌瘤内的溶血性肺炎链球菌抑制肿瘤进展
Ruijin Lu,Ju Zhu,Qinghua Song et al.
Ruijin Lu et al.
Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy worldwide with limited therapeutic options. Emerging evidence implicates intratumoral bacteria in ESCC pathogenesis. Here, we identified enriched levels of the Gram-positiv...
Ecological and evolutionary drivers of trait-based symbiosis and phylosymbiosis in avian gut microbiota [0.03%]
驱动鸟类肠道微生物组性状共生和系统发育共生的生态与进化因素
Siyu Wang,Cuiping Liu,Zewei Zhang et al.
Siyu Wang et al.
Lung function impairment and risk of sepsis and sepsis-related mortality: a large cohort study with over 310,000 participants [0.03%]
肺功能不全与全身感染及其相关死亡率的风险：一项涉及逾31万受试者的队列研究
Shaokang Xu,Yi Yang,Jian Shi et al.
Shaokang Xu et al.
Hypoxia is associated with systemic inflammation and oxidative stress, both of which contribute to sepsis development, yet whether impaired lung function is associated with a higher sepsis risk remains unclear. Leveraging data from 312,805 ...
Nicotinamide prevents anti-PD1 immune checkpoint inhibitor-associated early stages of cardiotoxicity [0.03%]
尼克酸可防止抗PD-1免疫检查点抑制剂相关的心脏毒性早期阶段
Lu Bai,Jing Zhao,Kang Dong et al.
Lu Bai et al.
Cardiac immune-related adverse events (irAEs) associated with anti-programmed death-1 (anti-PD1) immune checkpoint inhibitors (ICIs) are of major concern, as they can be fatal; however, their underlying molecular mechanisms remain poorly un...
Yu He,Xueming Ju,Huan Li et al.
Yu He et al.
Retinoblastoma (RB) is the most common pediatric intraocular malignancy and seriously threatens vision and survival if not treated early. However, effective targeted therapies remain unavailable owing to the lack of well-defined molecular t...
The proteomic blueprint of human aging: a 50-year, 13-tissue atlas [0.03%]
人类衰老的蛋白质组蓝图：一张为期50年，包含13种组织类型的图谱
Matthew X Fang,Tian-Min Fu
Matthew X Fang
Upregulation of m6A writer WTAP by histone lactylation promotes inflammatory response via TLR2 in neutrophils [0.03%]
组蛋白乳酸化通过促进中性粒细胞TLR2信号上调m6A写入因子WTAP并促进炎症反应
Bailu Du,Wenting Song,Yiming Zhang et al.
Bailu Du et al.
Elevated lactate levels are a hallmark of severe infections and are associated with poor outcomes in sepsis patients, but the underlying mechanisms remain poorly understood. Recent findings have shown that lactate can covalently modify hist...
Negative edge effects on forest carbon stocks in China: an estimate based on inventory data [0.03%]
基于资源清查数据的中国森林碳储量负边缘效应估算
Zeng Cui,Jinlong Chen,Zhiyao Tang
Zeng Cui
The vinculin-β-catenin axis promotes bone formation and repair: an essential prerequisite for the anti-osteoporotic efficacy of sclerostin-neutralizing antibody [0.03%]
vinculin-β-catenin轴促进骨形成和修复：抗骨质疏松抗体sclerostin中和抗体的作用前提条件
Sixiong Lin,Chu Tao,Yishu Wang et al.
Sixiong Lin et al.
Currently, targeting the Wnt/β-catenin pathway to promote bone formation is a primary strategy for the development of osteoporosis drugs. Here, we demonstrate that vinculin promotes bone mass increase and fracture repair by elevating the ...