STELLA: a spatial transcriptomics framework for microenvironment decoding using dynamic graph neural networks [0.03%]
STELLA：使用动态图神经网络解码微环境的单细胞空间转录组框架
Mengqiu Wang,Zhiwei Zhang,Xinxin Zhang et al.
Mengqiu Wang et al.
Spatial transcriptomics technology can analyze gene expression while retaining spatial information, but it is still challenging to accurately identify spatial domains and decode intercellular communication networks. This study proposes the ...
The DNA-binding protein PfAP2-V regulates erythrocyte invasion and pathogenesis of the human malaria parasite Plasmodium falciparum [0.03%]
一种DNA结合蛋白PfAP2-V调控人疟原虫红细胞侵染及毒力
Yanxin Zhang,Changhong Wang,Qilong Li et al.
Yanxin Zhang et al.
The pathogenesis of Plasmodium falciparum malaria involves coordinated molecular events, including host cell invasion, intraerythrocytic replication cycles, and antigenic variation, which are critically dependent on the stage-specific regul...
Apicidin is a key virulence determinant of Fusarium asiaticum in wheat-rice cropping systems [0.03%]
阿普西丁在小麦-水稻轮作系统中是亚洲型尖镰孢菌的关键毒力决定因子
Xin Liu,Kainan Li,Jianbo Qiu et al.
Xin Liu et al.
Apicidin, an emerging mycotoxin with potent histone deacetylase inhibitory and cytotoxic activities, is increasingly detected in wheat and rice in Jiangsu Province, China. Through a population-level screening, we identified a subset of Fusa...
Structure-driven RNA remodeling underlies broad substrate recognition by NSUN2 [0.03%]
结构驱动的RNA重塑是NSUN2蛋白广泛识别底物的基础
Qian Hu,Wen Yang,Yunyun Yu et al.
Qian Hu et al.
The human RNA m5C methyltransferase NSUN2 catalyzes site-specific cytosine methylation across diverse RNA substrates and thereby regulates a wide range of biological and physiological processes. However, the molecular basis by which NSUN2 a...
Histone chaperone HIRA restrains ferroptosis susceptibility through epigenetic control of iron metabolism in prostate cancer [0.03%]
组蛋白分子伴侣HIRA通过表观遗传调控铁代谢抑制前列腺癌细胞的铁死亡
Enlin Wang,Qilan Sun,Zhicheng Xu et al.
Enlin Wang et al.
Ferroptosis, an iron-dependent form of immunogenic cell death (ICD), represents a promising anti-tumor therapeutic strategy via effectively activating immune responses. However, the regulatory mechanisms governing ferroptosis in prostate ca...
High-density lipoprotein antioxidant function is associated with lipid profiles and lipid-lowering therapy [0.03%]
高密度脂蛋白抗氧化功能与血脂谱和降脂治疗有关
Hong-Yu Cao,Zhi-Wei Mo,Zhen-Sheng Ma et al.
Hong-Yu Cao et al.
Dyslipidemia is an important risk factor for coronary artery disease (CAD). However, the relationship between high-density lipoprotein (HDL) antioxidant function and plasma lipid profile has not been fully investigated. Lipid-lowering thera...
Ciliates: a window into the diversity and complexity of unicellular eukaryotic life [0.03%]
纤毛虫：单细胞真核生物多样性和复杂性的窗口
Feng Gao,Wei Miao,Xiaoyuan Song et al.
Feng Gao et al.
KLF6 regulates osteoclastogenesis through DUSP16 in OVX-induced bone loss [0.03%]
KLF6通过DUSP16调节卵巢切除诱导的骨丢失小鼠模型中的破骨细胞生成
Chen Yang,Wei Zhang,Xin Liu et al.
Chen Yang et al.
Estrogen deficiency results in enhanced bone resorption by osteoclasts, a critical factor in the development of postmenopausal osteoporosis. This study investigates the regulatory role of KLF6 in osteoclast differentiation and evaluates its...
E-Syt1 recruits PI4KA to endoplasmic reticulum-plasma membrane junctions to enhance PI4P synthesis [0.03%]
E-Syt1通过将PI4KA募集到内质网-细胞膜连接处来增强磷脂4磷酸的合成
Chunfang Tong,Ranran Mao,Dou Wang et al.
Chunfang Tong et al.
Phosphatidylinositol-4-phosphate (PI4P) is a low-abundance membrane lipid that plays crucial roles in lipid exchange and homeostasis, signal transduction, and vesicle trafficking. PI4KA, a type III phosphatidylinositol 4-kinase, catalyzes P...
The nucleosome assembly protein Nap1 regulates chromatin stability and nuclear division in Tetrahymena thermophila [0.03%]
热酸菌体内核小体组装蛋白Nap1调节染色质稳定性和细胞核分裂
Sitong Yang,Jin Mi,Jing Xu et al.
Sitong Yang et al.
Chromatin stability is essential for maintaining genome integrity and gene regulation in eukaryotic cells. Nucleosome assembly protein 1 (Nap1) is a key regulator of chromatin dynamics across different organisms. The ciliate Tetrahymena the...