The risk of pathogenic tick-borne viruses in Northeast Asia: a genomic and ecological modelling study [0.03%]
东北亚致病性蜱传病毒风险的基因组及生态建模研究
Moujian Guo,Hengcong Liu,Hong Zhou et al.
Moujian Guo et al.
The prevalence, epidemiological history and disease risk posed by pathogenic tick-borne viruses (TBVs) remain poorly understood in Northeast Asia. Here, over 12,000 ticks were collected from diverse ecological environments in Northeast Chin...
SREBP1-activated lipid metabolism drives ferroptosis and progression of clear cell renal cell carcinoma [0.03%]
SREBP1激活的脂质代谢驱动透明细胞肾细胞癌的铁死亡和进展
Bao Wang,Junpeng Fu,Jian Qian et al.
Bao Wang et al.
Clear cell renal cell carcinoma (ccRCC) exhibits aberrant lipid synthesis, yet how this metabolic reprogramming influences ferroptosis-a form of regulated cell death driven by lipid peroxidation-remains poorly understood. This study demonst...
Targeting SHOC2: a treatable therapeutic site in RAS(Q61) mutant cancers [0.03%]
靶向SHOC2：在RAS(Q61)突变癌症中的可治疗性治疗位点
Junliang Tang,Guoqing Ding,Jie Zhang
Junliang Tang
Approaching the perfection of natural enzymes: evolution of biomimetic catalytic systems [0.03%]
迈向天然酶完美的境界——仿生催化体系的进化
Sai Zhu,Zuoyi Liu,Cuiqi Liang et al.
Sai Zhu et al.
Weiqiong Feng,Zhenyang Xie,Hao Huang
Weiqiong Feng
Wnt signaling dysregulation drives Stargardt disease pathogenesis [0.03%]
WNting调控障碍驱动Stargardt病发病机制
Xiao Zhang,Zhuo-Lin Liu,Xiao Lin et al.
Xiao Zhang et al.
Stargardt disease, the most common inherited juvenile macular degeneration, is primarily caused by ABCA4 mutations, yet the cellular origin of pathology remains debated. Here, we identify a critical role for Wnt signaling dysregulation, spe...
Oxidative stress affects intestinal health by inhibiting the differentiation of porcine intestinal epithelial cells through producing arachidonic acid [0.03%]
氧化应激通过产生花生四烯酸抑制猪小肠上皮细胞分化从而影响肠道健康
Yitong Zhang,Guanping Xiao,Xianglin Zeng et al.
Yitong Zhang et al.
The intestinal epithelium is particularly vulnerable to oxidative stress caused by intracavitary stimulation, but the molecular mechanisms driving this damage remain poorly understood. The arachidonic acid (AA) pathway was significantly enr...
A secreted alpha-amylase effectively induces reproductive cyst formation both within and across Colpoda species, key soil-dwelling protists [0.03%]
一种有效的分泌型α-淀粉酶能够诱导Colpoda物种（关键的土壤栖息原生动物）内部和跨物种生殖包囊形成
Zixin Cheng,Zhongqiao Song,Kejia Fu et al.
Zixin Cheng et al.
Colpoda are among the most predominant eukaryotic microorganisms in soil ecosystems, playing crucial roles in material and energy cycling within soil and plant rhizosphere environments. Colpoda can form two distinct types of cysts in soil: ...
Hematopoiesis could be improved by correcting aberrant bone marrow macrophages polarization in aplastic anemia patients [0.03%]
改善再生障碍性贫血患者异常骨髓巨噬细胞极化以提高造血功能
Chen-Yuan Li,Dan-Dan Chen,Xin-Yan Zhang et al.
Chen-Yuan Li et al.
The immune-mediated destruction of hematopoietic stem cells (HSCs) is the most recognized mechanism of aplastic anemia (AA); however, the unfavorable therapeutic effect of immunosuppressive therapy (IST) has shown that the pathogenesis of A...
Multi-omics analyses of the Alviniconcha holobiont reveal multi-faceted adaptations to deep-sea hydrothermal vents [0.03%]
基于Alviniconcha的多组学分析揭示了深海热液适应的多层次表型机制
Hui Wang,Yuran Dai,Chong Chen et al.
Hui Wang et al.
Deep-sea hydrothermal vents are "extreme" environments with constantly fluctuating physicochemical conditions, but dense animal aggregations thrive primarily through symbiosis with chemoautotrophic bacteria to exploit the unusual chemistry....