Berberine combined with stachyose protects against obesity by modulating gut microbiota and increasing leptin sensitivity [0.03%]
巴马チン联合鼠李糖诱导肠道微生物变化增加瘦素敏感性以对抗肥胖发生发展趋势
Dan Wu,Feng Zhang,Huiying Wang et al.
Dan Wu et al.
Leptin resistance is a hallmark of obesity. Recent evidence shows that gut microbiota is associated with the development and progression of leptin resistance. However, whether intervention targeting gut microbiota can improve leptin sensiti...
Ruobin Zhao,Shaozhen Yin,Qiangfeng Cliff Zhang et al.
Ruobin Zhao et al.
Toward a comprehensive map of Rab-mediated cargo transport to migrasomes [0.03%]
朝向全面绘制Rab介导的迁移到迁徙体的货物运输地图
Yiling Wen,Yong Li,Jiayi Chen et al.
Yiling Wen et al.
Unveiling the choroidal immune landscape revealed interferon-gamma and TNF-alpha as novel therapeutic targets in dry AMD [0.03%]
揭示脉络膜免疫特征发现γ干扰素和TNF-α是治疗干性年龄相关性黄斑变性的新靶点
Lin Ye,Tujing Zhao,Huaping Tian et al.
Lin Ye et al.
Age-related macular degeneration (AMD), particularly its atrophic (dry) form, is a leading cause of irreversible blindness in the elderly. Limited treatment efficacy stems from its complex pathogenesis, highlighting an urgent need for novel...
TurboID-based proximity labeling identifies novel germline proteins that maintain E granule integrity and small RNA homeostasis in C. elegans [0.03%]
基于TurboID的接近标记法鉴定出新型生殖系蛋白以维持秀丽隐杆线虫E颗粒完整性和小RNA稳态
Kun Li,Xuezhu Feng,Ke Wang et al.
Kun Li et al.
Germ granules are biomolecular condensates composed of RNA and proteins that play crucial roles in RNA metabolism and post-transcriptional gene regulation. C. elegans germ granules consist of multiple distinct subcompartments, including P g...
Chang-Wang Ma,Dan Xie,Hong Du et al.
Chang-Wang Ma et al.
Glutathione contributes to alleviating hepatic injury via host-microbiome interaction and CAR-dependent pathway [0.03%]
谷胱甘肽通过宿主-微生物互作和CAR依赖性通路贡献于肝脏损伤的缓解
Xuan Xiang,Siwei Liu,Houfu Wang et al.
Xuan Xiang et al.
Glutathione (GSH) is a potent antioxidant regulating oxidative stress, but whether exogenous GSH supplementation mitigates stress injury through host-microbiome and liver interactions remains unclear. This study aimed to determine the regul...
Enhancement of in vitro transcribed (IVT) mRNA translation efficiency through engineered poly(A) tails [0.03%]
通过工程化多聚腺苷酸尾巴提高体外转录（IVT）mRNA的翻译效率
Yusheng Liu,Hu Nie,Rongrong Sun et al.
Yusheng Liu et al.
From modeling to therapy: the efficient and precise tools for mitochondrial base editing [0.03%]
从建模到治疗：高效的线粒体碱基编辑精准工具
Si-Si Xie,Xiang Li,Hao Yin
Si-Si Xie
NRT1.1B: a dual receptor integrating ABA and nitrate signals for plant adaptation to compound stresses [0.03%]
NRT1.1B：一个集成ABA和硝酸盐信号的双重受体以应对复合胁迫的植物适应性反应
Zhizhong Gong,Shuhua Yang
Zhizhong Gong