Junjie Mu,Xi Yang,Yongbo Li et al.
Junjie Mu et al.
As studies aimed at clarifying the evolution of cognition in animals accumulate, some non-human primates are widely considered to be the most cognitively advanced species after humans. Cognitive processes related to social interaction and e...
CRISPR-Cas9-mediated uATG introduction in the 5'UTR of the Uox gene for hyperuricemia mouse models: implications for gout and metabolic disorders [0.03%]
基于Uox基因5'UTR的uATG引入的CRISPR-Cas9介导的高尿酸血症小鼠模型：痛风和代谢障碍的相关性研究
Guolong Liu,Xiaoling Tian,Lu Ye et al.
Guolong Liu et al.
Sequence-specific gene knockdown technologies are crucial for fundamental research and therapeutic applications. RNA interference and CRISPR interference, while extensively utilized for gene expression manipulation, face limitations due to ...
Deficiency of primate-specific TFDP3 causes male infertility with oligoasthenoteratozoospermia in humans and cynomolgus monkeys [0.03%]
灵长类特异性TFDP3缺乏导致人类和食蟹猴的轻度少弱精症不孕症
Chunyu Liu,Chaofeng Tu,Peng Li et al.
Chunyu Liu et al.
Primate-specific genes (PSGs), important contributors to the origin of adaptive evolutionary novelties, are abundantly expressed in the testis. However, the specific roles of PSGs in the male reproductive system of humans and other primates...
Comprehensive phylogenomic analyses of ciliated protists with a revised classification of the phylum Ciliophora (Eukaryota, Alveolata) [0.03%]
纤毛虫谱系基因组综合分析及顶复合纤毛门（真核域，顶复门）的修订分类法
Yurui Wang,Ying Yan,Zhenzhen Yi et al.
Yurui Wang et al.
Phylogenomic analyses are instrumental in enhancing our comprehension of evolutionary relationships across the tree of life. Among eukaryotes, ciliates are one of the most diverse groups of single-cell eukaryotes that play important roles i...
ESIRA, a novel framework integrating efficacy and safety for evaluating first-line treatments in advanced hepatocellular carcinoma [0.03%]
ESIRA：一种新颖的框架，用于结合疗效和安全性评估晚期肝细胞癌一线治疗的效果
Hai-Long Li,Hui Zhou,Yi-Yang Zhang et al.
Hai-Long Li et al.
Selecting first-line treatments for advanced hepatocellular carcinoma (HCC) requires carefully balancing the survival benefits against the risk of serious adverse events (SAEs). However, conventional evaluation methods often fail to incorpo...
Loss-of-function mutations in PLD4: a new genomics-guided roadmap for type I interferon-centric lupus [0.03%]
PLD4功能丧失型突变：一种新的基因组学导向的以I型干扰素为中心的红斑狼疮诊疗方案
Yu-Lin Yao,Li Huang,Yanfei Guo et al.
Yu-Lin Yao et al.
SPHK1 deficiency promotes intestinal homeostasis by ameliorating ER stress-induced gastrointestinal injury during murine graft-versus-host disease [0.03%]
SPHK1缺乏通过改善小鼠移植物抗宿主病中的内质网应激诱导的胃肠损伤来促进肠道稳态
Di Wu,Xinhui Zhao,Yajing Pu et al.
Di Wu et al.
Graft-versus-host disease (GVHD) remains a major challenge in successful allogeneic hematopoietic stem cell transplantation. Here, we report that inhibiting sphingosine kinase 1 (SPHK1), an enzyme that phosphorylates sphingosine to bioactiv...
Strategies and mechanisms for the enhancement of chimeric antigen receptor T-cell functions [0.03%]
增强嵌合抗原受体T细胞功能的策略和机制
Shi Han,Juan Yue,Haiqiong Zheng et al.
Shi Han et al.
Chimeric antigen receptor-T (CAR-T) cell therapy has made considerable advancements in the treatment of malignant tumors; however, its clinical application continues to face challenges such as low response rates and relapse, which are criti...
Advances in Alzheimer's disease: mechanistic insights and therapeutic targets [0.03%]
阿尔茨海默病研究进展：发病机制和治疗靶点的启示
Yu-Juan Jia,Yi-Jun Ge,Bowei Li et al.
Yu-Juan Jia et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline, memory loss, and behavioral disturbances, eventually leading to dementia and severely diminishing quality of life. With the global population ...