Wnt signaling dysregulation drives Stargardt disease pathogenesis [0.03%]
WNting调控障碍驱动Stargardt病发病机制
Xiao Zhang,Zhuo-Lin Liu,Xiao Lin et al.
Xiao Zhang et al.
Stargardt disease, the most common inherited juvenile macular degeneration, is primarily caused by ABCA4 mutations, yet the cellular origin of pathology remains debated. Here, we identify a critical role for Wnt signaling dysregulation, spe...
Oxidative stress affects intestinal health by inhibiting the differentiation of porcine intestinal epithelial cells through producing arachidonic acid [0.03%]
氧化应激通过产生花生四烯酸抑制猪小肠上皮细胞分化从而影响肠道健康
Yitong Zhang,Guanping Xiao,Xianglin Zeng et al.
Yitong Zhang et al.
The intestinal epithelium is particularly vulnerable to oxidative stress caused by intracavitary stimulation, but the molecular mechanisms driving this damage remain poorly understood. The arachidonic acid (AA) pathway was significantly enr...
A secreted alpha-amylase effectively induces reproductive cyst formation both within and across Colpoda species, key soil-dwelling protists [0.03%]
一种有效的分泌型α-淀粉酶能够诱导Colpoda物种（关键的土壤栖息原生动物）内部和跨物种生殖包囊形成
Zixin Cheng,Zhongqiao Song,Kejia Fu et al.
Zixin Cheng et al.
Colpoda are among the most predominant eukaryotic microorganisms in soil ecosystems, playing crucial roles in material and energy cycling within soil and plant rhizosphere environments. Colpoda can form two distinct types of cysts in soil: ...
Hematopoiesis could be improved by correcting aberrant bone marrow macrophages polarization in aplastic anemia patients [0.03%]
改善再生障碍性贫血患者异常骨髓巨噬细胞极化以提高造血功能
Chen-Yuan Li,Dan-Dan Chen,Xin-Yan Zhang et al.
Chen-Yuan Li et al.
The immune-mediated destruction of hematopoietic stem cells (HSCs) is the most recognized mechanism of aplastic anemia (AA); however, the unfavorable therapeutic effect of immunosuppressive therapy (IST) has shown that the pathogenesis of A...
Multi-omics analyses of the Alviniconcha holobiont reveal multi-faceted adaptations to deep-sea hydrothermal vents [0.03%]
基于Alviniconcha的多组学分析揭示了深海热液适应的多层次表型机制
Hui Wang,Yuran Dai,Chong Chen et al.
Hui Wang et al.
Deep-sea hydrothermal vents are "extreme" environments with constantly fluctuating physicochemical conditions, but dense animal aggregations thrive primarily through symbiosis with chemoautotrophic bacteria to exploit the unusual chemistry....
The contributions of two fertilization events to the fertilization recovery efficiency in Arabidopsis [0.03%]
拟南芥两次授粉事件对受精恢复效率的贡献
Yuan Wang,Yaxiao Liu,Wenhao Li et al.
Yuan Wang et al.
In angiosperms, fertilization recovery refers to the phenomenon wherein an ovule, upon failure of both sperm cells released by the initial pollen tube to achieve fertilization, continues to attract subsequent pollen tubes to salvage fertili...
Collaboration of the symbiotic microbiome and host genome during the high altitude adaptation of chickens [0.03%]
鸡高海拔适应过程中协同作用的共生微生物组和宿主基因组
Jiaming Jin,Chaoliang Wen,Junying Li et al.
Jiaming Jin et al.
The harsh environments of high-altitude habitats present formidable challenges for animal survival and reproduction. The adaptation of plateau endotherms to hypoxic and cold stresses has been studied for more than a century. However, the re...
A review of computational approaches for metagenomics by long-read sequencing [0.03%]
长读段测序元基因组的计算方法综述
Baichen Le,Longhao Jia,Tianxiang Pang et al.
Baichen Le et al.
The metagenomic next-generation sequencing (mNGS), also known as short-read sequencing (SRS), is widely used to explore microbial composition and function. However, short reads, due to their difficulty in crossing repetitive regions, can le...
Butyrate supplementation in sows promotes offspring embryonic muscle development by upregulating HDAC-mediated H3K27ac levels and myogenic gene expression [0.03%]
丁酸补饲通过上调组蛋白乙酰化修饰促进母猪胚胎期肌肉发育
Hao Zuo,Chen Li,Xiaoyu Niu et al.
Hao Zuo et al.
Butyrate, an important short-chain fatty acid, plays multiple biological roles in animal growth and development. Our previous studies have revealed that SYISL knockout in mother mice can enhance embryonic muscle development in their offspri...
Chromatin accessibility dynamics and transcriptional regulation in Tetrahymena thermophila [0.03%]
热膨化热体纤毛虫染色质动态和转录调控
Tengfei Hu,Zhengyu Luo,Xiaoyuan Song
Tengfei Hu
Chromatin accessibility is a key determinant of transcriptional regulation across eukaryotes, yet its organization and functional significance in ciliated protists remain poorly defined. Here, we optimized ATAC-seq to delineate the chromati...